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Drug-induced gastrointestinal toxicity and barrier integrity: cytoskeleton-mediated impairment in a clinically relevant human intestinal epithelium model.

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Title: Drug-induced gastrointestinal toxicity and barrier integrity: cytoskeleton-mediated impairment in a clinically relevant human intestinal epithelium model.
Authors: Yu WD; Korea Research Institute of Bioscience and Biotechnology, Daejeon, Korea.; KRIBB School of Bioscience, Korea University of Science and Technology, Daejeon, Korea., Lee S; Korea Research Institute of Bioscience and Biotechnology, Daejeon, Korea., Cho HS; Korea Research Institute of Bioscience and Biotechnology, Daejeon, Korea.; KRIBB School of Bioscience, Korea University of Science and Technology, Daejeon, Korea., Kwon O; Korea Research Institute of Bioscience and Biotechnology, Daejeon, Korea.; KRIBB School of Bioscience, Korea University of Science and Technology, Daejeon, Korea., Lim JH; Korea Research Institute of Bioscience and Biotechnology, Daejeon, Korea.; KRIBB School of Bioscience, Korea University of Science and Technology, Daejeon, Korea., Jung CR; Korea Research Institute of Bioscience and Biotechnology, Daejeon, Korea.; KRIBB School of Bioscience, Korea University of Science and Technology, Daejeon, Korea., Jang B; Korea Research Institute of Bioscience and Biotechnology, Daejeon, Korea., Lee KJ; ORGANOIDSCIENCES, Seongnam, Republic of Korea.; Lambda Biologics, Leipzig, Germany., Yoo J; ORGANOIDSCIENCES, Seongnam, Republic of Korea.; CHA Organoid Research Center, CHA University, Seongnam, Republic of Korea., Kim DS; Korea Research Institute of Bioscience and Biotechnology, Daejeon, Korea. kds2465@kribb.re.kr.; KRIBB School of Bioscience, Korea University of Science and Technology, Daejeon, Korea. kds2465@kribb.re.kr., Lee H; Korea Research Institute of Bioscience and Biotechnology, Daejeon, Korea. hnlee@kribb.re.kr., Son MY; Korea Research Institute of Bioscience and Biotechnology, Daejeon, Korea. myson@kribb.re.kr.; KRIBB School of Bioscience, Korea University of Science and Technology, Daejeon, Korea. myson@kribb.re.kr.; School of Medicine, Sungkyunkwan University, Suwon, Republic of Korea. myson@kribb.re.kr.
Source: Experimental & molecular medicine [Exp Mol Med] 2026 Mar; Vol. 58 (2), pp. 487-500. Date of Electronic Publication: 2026 Feb 12.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: United States NLM ID: 9607880 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2092-6413 (Electronic) Linking ISSN: 12263613 NLM ISO Abbreviation: Exp Mol Med Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2092-6413
DOI:10.1038/s12276-025-01635-6