Targeting HIF-2α in colorectal cancer reveals a cholesterol biosynthesis-dependent ferroptotic vulnerability.

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Title: Targeting HIF-2α in colorectal cancer reveals a cholesterol biosynthesis-dependent ferroptotic vulnerability.
Authors: Dalal PJ; Department of Internal Medicine, Division of Hematology/Oncology, University of Michigan, Ann Arbor, MI, USA.; Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI, USA., Singhal R; Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI, USA., Hu B; Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI, USA., Stark D; Cancer Biology Program, University of Michigan, Ann Arbor, MI, USA., Rossiter NJ; Cell and Molecular Biology Program, University of Michigan, Ann Arbor, MI, USA., Jain C; Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI, USA., Sajjakulnukit P; Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI, USA., Lyssiotis CA; Department of Internal Medicine, Division of Gastroenterology, University of Michigan, Ann Arbor, MI, USA.; University of Michigan, Rogel Cancer Center, Ann Arbor, MI, USA.; Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI, USA.; Cancer Biology Program, University of Michigan, Ann Arbor, MI, USA., Shah YM; Department of Internal Medicine, Division of Gastroenterology, University of Michigan, Ann Arbor, MI, USA. shahy@umich.edu.; University of Michigan, Rogel Cancer Center, Ann Arbor, MI, USA. shahy@umich.edu.; Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI, USA. shahy@umich.edu.; Cell and Molecular Biology Program, University of Michigan, Ann Arbor, MI, USA. shahy@umich.edu.; Cancer Biology Program, University of Michigan, Ann Arbor, MI, USA. shahy@umich.edu.
Source: Cancer & metabolism [Cancer Metab] 2026 Feb 12; Vol. 14 (1). Date of Electronic Publication: 2026 Feb 12.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101607582 Publication Model: Electronic Cited Medium: Print ISSN: 2049-3002 (Print) Linking ISSN: 20493002 NLM ISO Abbreviation: Cancer Metab Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2049-3002
DOI:10.1186/s40170-026-00421-w