Iron overload induced by ferric derisomaltose and ferric carboxymaltose both increase FGF-23 levels and lead to osteomalacia and bone loss in normal mice.

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Title: Iron overload induced by ferric derisomaltose and ferric carboxymaltose both increase FGF-23 levels and lead to osteomalacia and bone loss in normal mice.
Authors: Le-Phuoc XT; Department of Medicine III Center for Healthy Aging, Medical Faculty, University Hospital Carl Gustav Carus, Dresden University of Technology, Fetscherstr. 74, 01307, Dresden, Germany., Passin V; Department of Medicine III Center for Healthy Aging, Medical Faculty, University Hospital Carl Gustav Carus, Dresden University of Technology, Fetscherstr. 74, 01307, Dresden, Germany., Ledesma-Colunga MG; Department of Medicine III Center for Healthy Aging, Medical Faculty, University Hospital Carl Gustav Carus, Dresden University of Technology, Fetscherstr. 74, 01307, Dresden, Germany., Weidner H; Department of Medicine III Center for Healthy Aging, Medical Faculty, University Hospital Carl Gustav Carus, Dresden University of Technology, Fetscherstr. 74, 01307, Dresden, Germany., Fiedler I; Department of Osteology and Biomechanics, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Interdisciplinary Competence Center for Interface Research (ICCIR), University Medical Center Hamburg-Eppendorf (UKE) Hamburg, Hamburg, Germany., Busse B; Department of Osteology and Biomechanics, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Interdisciplinary Competence Center for Interface Research (ICCIR), University Medical Center Hamburg-Eppendorf (UKE) Hamburg, Hamburg, Germany., Baschant U; Department of Medicine III Center for Healthy Aging, Medical Faculty, University Hospital Carl Gustav Carus, Dresden University of Technology, Fetscherstr. 74, 01307, Dresden, Germany., Hofbauer LC; Department of Medicine III Center for Healthy Aging, Medical Faculty, University Hospital Carl Gustav Carus, Dresden University of Technology, Fetscherstr. 74, 01307, Dresden, Germany., Rauner M; Department of Medicine III Center for Healthy Aging, Medical Faculty, University Hospital Carl Gustav Carus, Dresden University of Technology, Fetscherstr. 74, 01307, Dresden, Germany. martina.rauner@ukdd.de.
Source: Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine [Biometals] 2026 Jun; Vol. 39 (3), pp. 953-971. Date of Electronic Publication: 2026 Feb 13.
Publication Type: Journal Article
Journal Info: Publisher: Kluwer Academic Publishers Country of Publication: Netherlands NLM ID: 9208478 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1572-8773 (Electronic) Linking ISSN: 09660844 NLM ISO Abbreviation: Biometals Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1572-8773
DOI:10.1007/s10534-026-00794-x