Distinct mutations in the autoimmune regulator gene differentially affect transcriptional and functional properties of medullary thymic epithelial cells.

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Title: Distinct mutations in the autoimmune regulator gene differentially affect transcriptional and functional properties of medullary thymic epithelial cells.
Authors: Tanaka PP; Molecular Immunogenetics Group, Department of Genetics, Ribeirão Preto Medical School, University of São Paulo, 3900, Bandeirantes Avenue, 14040-900, Ribeirão Preto, SP, Brazil., Cotta-Almeida V; Laboratory on Thymus Research, Oswaldo Cruz Foundation, Fiocruz, 4365, Brasil Avenue, Rio de Janeiro, RJ, 21040-360, Brazil.; National Institute of Science and Technology on Neuroimmunomodulation, INCT-NIM, Fiocruz, 4365, Brasil Avenue, Rio de Janeiro, RJ, 21040-360, Brazil.; Rio de Janeiro Research Network on Neuroinflammation, RENEURIN, Fiocruz, 4365, Brasil Avenue, Rio de Janeiro, RJ, 21040-360, Brazil., Donadi EA; Department of Clinical Medicine, Division of Clinical Immunology, Ribeirão Preto Medical School, University of São Paulo, 3900, Bandeirantes Avenue, 14040-900, Ribeirão Preto, SP, Brazil., Westerberg L; Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Nobels väg 5, 17165 Stockholm, Sweden., Passos GA; Molecular Immunogenetics Group, Department of Genetics, Ribeirão Preto Medical School, University of São Paulo, 3900, Bandeirantes Avenue, 14040-900, Ribeirão Preto, SP, Brazil.; Laboratory of Genetics and Molecular Biology, Department of Basic and Oral Biology, Ribeirão Preto School of Dentistry, University of São Paulo, Via do Café s/n, Ribeirão Preto, SP, 14040-904, Brazil.; Center for Cell-Based Therapy in Dentistry, Ribeirão Preto School of Dentistry, University of São Paulo, Via do Café s/n, Ribeirão Preto, SP, 14040-904, Brazil.
Source: Human molecular genetics [Hum Mol Genet] 2026 Feb 23; Vol. 35 (4).
Publication Type: Journal Article
Journal Info: Publisher: IRL Press at Oxford University Press Country of Publication: England NLM ID: 9208958 Publication Model: Print Cited Medium: Internet ISSN: 1460-2083 (Electronic) Linking ISSN: 09646906 NLM ISO Abbreviation: Hum Mol Genet Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1460-2083
DOI:10.1093/hmg/ddag004