Clinical validation of a tissue-agnostic genome-wide methylome enrichment assay to monitor response to pembrolizumab.
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| Title: | Clinical validation of a tissue-agnostic genome-wide methylome enrichment assay to monitor response to pembrolizumab. |
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| Authors: | Stutheit-Zhao EY; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada., Zhong Y; Adela, Inc., Foster City, CA, USA., Melton CA; Adela, Inc., Foster City, CA, USA., Lightbody ED; Adela, Inc., Foster City, CA, USA., Hinterberg MA; Adela, Inc., Foster City, CA, USA., Wang Y; Adela, Inc., Foster City, CA, USA., Hall O; Adela, Inc., Foster City, CA, USA., Sosa EV; Adela, Inc., Foster City, CA, USA., Provance JB; Adela, Inc., Foster City, CA, USA., Zhang J; Adela, Inc., Foster City, CA, USA., Licon A; Adela, Inc., Foster City, CA, USA., Liu ZA; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada., Abdul Razak AR; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada., Spreafico A; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada., Bedard PL; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada., Hansen AR; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada., Lheureux S; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada., Ohashi PS; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.; Department of Immunology, University of Toronto, Toronto, ON, Canada., Williams A; Adela, Inc., Foster City, CA, USA., Bratman SV; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.; Department of Medical Biophysics, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada., Allen BA; Adela, Inc., Foster City, CA, USA., Zhang J; Adela, Inc., Foster City, CA, USA., De Carvalho DD; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.; Department of Medical Biophysics, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada., Hartman AR; Adela, Inc., Foster City, CA, USA., Siu LL; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada., Sanz-Garcia E; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada. enrique.sanzgarcia@uhn.ca. |
| Source: | NPJ precision oncology [NPJ Precis Oncol] 2026 Feb 13; Vol. 10 (1). Date of Electronic Publication: 2026 Feb 13. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Springer Nature Country of Publication: England NLM ID: 101708166 Publication Model: Electronic Cited Medium: Print ISSN: 2397-768X (Print) Linking ISSN: 2397768X NLM ISO Abbreviation: NPJ Precis Oncol Subsets: PubMed not MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2397-768X |
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| DOI: | 10.1038/s41698-026-01327-y |
