Loss of Myonuclei and Transcriptional Activity During Diaphragm Atrophy in Critically Ill Patients.

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Title: Loss of Myonuclei and Transcriptional Activity During Diaphragm Atrophy in Critically Ill Patients.
Authors: Claassen WJ; Department of Physiology, Amsterdam UMC, location VUmc, Amsterdam, the Netherlands., van den Berg M; Department of Physiology, Amsterdam UMC, location VUmc, Amsterdam, the Netherlands.; Department of Cellular and Molecular Medicine, University of Arizona, Tucson, Arizona, USA., Shi ZH; Department of Physiology, Amsterdam UMC, location VUmc, Amsterdam, the Netherlands., Baelde RJ; Department of Physiology, Amsterdam UMC, location VUmc, Amsterdam, the Netherlands., Bogaards S; Department of Physiology, Amsterdam UMC, location VUmc, Amsterdam, the Netherlands., Bonis L; Department of Physiology, Amsterdam UMC, location VUmc, Amsterdam, the Netherlands., Hakkeling H; Department of Physiology, Amsterdam UMC, location VUmc, Amsterdam, the Netherlands., Bamyani A; Department of Physiology, Amsterdam UMC, location VUmc, Amsterdam, the Netherlands., Schaaf GJ; Center for Lysosomal and Metabolic Diseases, Erasmus University Medical Center, Rotterdam, the Netherlands., Beishuizen A; Intensive care Center, Medisch Spectrum Twente, Enschede, the Netherlands., Dickhoff C; Department of Surgery, Amsterdam UMC, location VUmc, Amsterdam, the Netherlands., Boon RA; Department of Physiology, Amsterdam UMC, location VUmc, Amsterdam, the Netherlands., Heunks L; Department of Intensive Care Medicine, Radboudumc, Nijmegen, the Netherlands., Kirby TJ; Department of Physiology, Amsterdam UMC, location VUmc, Amsterdam, the Netherlands.; Division of Cardiovascular Medicine, Department of Internal Medicine, University of Kentucky, Lexington, Kentucky, USA., Ottenheijm CAC; Department of Physiology, Amsterdam UMC, location VUmc, Amsterdam, the Netherlands.; Department of Cellular and Molecular Medicine, University of Arizona, Tucson, Arizona, USA.
Source: Journal of cachexia, sarcopenia and muscle [J Cachexia Sarcopenia Muscle] 2026 Feb; Vol. 17 (1), pp. e70228.
Publication Type: Journal Article
Journal Info: Publisher: John Wiley & Sons Ltd on behalf of Society on Sarcopenia, Cachexia and Wasting Disorders Country of Publication: Germany NLM ID: 101552883 Publication Model: Print Cited Medium: Internet ISSN: 2190-6009 (Electronic) Linking ISSN: 21905991 NLM ISO Abbreviation: J Cachexia Sarcopenia Muscle Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:2190-6009
DOI:10.1002/jcsm.70228