Tumor-reactive TCRs within exhausted TILs reveal cancer type-specific immune landscapes in renal cell carcinoma.

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Title: Tumor-reactive TCRs within exhausted TILs reveal cancer type-specific immune landscapes in renal cell carcinoma.
Authors: Komahashi M; Division of Cancer Immunotherapy, Kanagawa Cancer Center Research Institute, Yokohama, Japan.; Cancer Vaccine and Immunotherapy Center, Kanagawa Cancer Center Research Institute, Yokohama, Japan.; Department of Pediatric Surgery, Nihon University School of Medicine, Tokyo, Japan., Horaguchi S; Division of Cancer Immunotherapy, Kanagawa Cancer Center Research Institute, Yokohama, Japan.; Cancer Vaccine and Immunotherapy Center, Kanagawa Cancer Center Research Institute, Yokohama, Japan.; Department of Pediatric Surgery, Nihon University School of Medicine, Tokyo, Japan., Tsuji K; Division of Cancer Immunotherapy, Kanagawa Cancer Center Research Institute, Yokohama, Japan.; Cancer Vaccine and Immunotherapy Center, Kanagawa Cancer Center Research Institute, Yokohama, Japan., Hoshino D; Cancer Biology Division, Kanagawa Cancer Center Research Institute, Yokohama, Japan., Kishida T; Department of Urology, Kanagawa Cancer Center, Yokohama, Japan., Usui K; Department of Urology, Kanagawa Cancer Center, Yokohama, Japan., Nakaigawa N; Department of Urology, Kanagawa Cancer Center, Yokohama, Japan., Sato S; Molecular Pathology and Genetics Division, Kanagawa Cancer Center Research Institute, Yokohama, Japan.; Morphological Information Laboratory, Kanagawa Cancer Center Research Institute, Yokohama, Japan., Hamana H; Department of Immunology, Faculty of Medicine, Academic Assembly, University of Toyama, Toyama, Japan., Kishi H; Department of Immunology, Faculty of Medicine, Academic Assembly, University of Toyama, Toyama, Japan., Wei F; Division of Cancer Immunotherapy, Kanagawa Cancer Center Research Institute, Yokohama, Japan.; Cancer Vaccine and Immunotherapy Center, Kanagawa Cancer Center Research Institute, Yokohama, Japan., Mano Y; Division of Cancer Immunotherapy, Kanagawa Cancer Center Research Institute, Yokohama, Japan.; Cancer Vaccine and Immunotherapy Center, Kanagawa Cancer Center Research Institute, Yokohama, Japan., Kouro T; Division of Cancer Immunotherapy, Kanagawa Cancer Center Research Institute, Yokohama, Japan.; Cancer Vaccine and Immunotherapy Center, Kanagawa Cancer Center Research Institute, Yokohama, Japan., Uehara S; Department of Pediatric Surgery, Nihon University School of Medicine, Tokyo, Japan., Sasada T; Division of Cancer Immunotherapy, Kanagawa Cancer Center Research Institute, Yokohama, Japan.; Cancer Vaccine and Immunotherapy Center, Kanagawa Cancer Center Research Institute, Yokohama, Japan.
Source: Frontiers in immunology [Front Immunol] 2026 Jan 29; Vol. 17, pp. 1729388. Date of Electronic Publication: 2026 Jan 29 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE
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  Data: Tumor-reactive TCRs within exhausted TILs reveal cancer type-specific immune landscapes in renal cell carcinoma.
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  Data: <searchLink fieldCode="AU" term="%22Komahashi+M%22">Komahashi M</searchLink>; Division of Cancer Immunotherapy, Kanagawa Cancer Center Research Institute, Yokohama, Japan.; Cancer Vaccine and Immunotherapy Center, Kanagawa Cancer Center Research Institute, Yokohama, Japan.; Department of Pediatric Surgery, Nihon University School of Medicine, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Horaguchi+S%22">Horaguchi S</searchLink>; Division of Cancer Immunotherapy, Kanagawa Cancer Center Research Institute, Yokohama, Japan.; Cancer Vaccine and Immunotherapy Center, Kanagawa Cancer Center Research Institute, Yokohama, Japan.; Department of Pediatric Surgery, Nihon University School of Medicine, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Tsuji+K%22">Tsuji K</searchLink>; Division of Cancer Immunotherapy, Kanagawa Cancer Center Research Institute, Yokohama, Japan.; Cancer Vaccine and Immunotherapy Center, Kanagawa Cancer Center Research Institute, Yokohama, Japan.<br /><searchLink fieldCode="AU" term="%22Hoshino+D%22">Hoshino D</searchLink>; Cancer Biology Division, Kanagawa Cancer Center Research Institute, Yokohama, Japan.<br /><searchLink fieldCode="AU" term="%22Kishida+T%22">Kishida T</searchLink>; Department of Urology, Kanagawa Cancer Center, Yokohama, Japan.<br /><searchLink fieldCode="AU" term="%22Usui+K%22">Usui K</searchLink>; Department of Urology, Kanagawa Cancer Center, Yokohama, Japan.<br /><searchLink fieldCode="AU" term="%22Nakaigawa+N%22">Nakaigawa N</searchLink>; Department of Urology, Kanagawa Cancer Center, Yokohama, Japan.<br /><searchLink fieldCode="AU" term="%22Sato+S%22">Sato S</searchLink>; Molecular Pathology and Genetics Division, Kanagawa Cancer Center Research Institute, Yokohama, Japan.; Morphological Information Laboratory, Kanagawa Cancer Center Research Institute, Yokohama, Japan.<br /><searchLink fieldCode="AU" term="%22Hamana+H%22">Hamana H</searchLink>; Department of Immunology, Faculty of Medicine, Academic Assembly, University of Toyama, Toyama, Japan.<br /><searchLink fieldCode="AU" term="%22Kishi+H%22">Kishi H</searchLink>; Department of Immunology, Faculty of Medicine, Academic Assembly, University of Toyama, Toyama, Japan.<br /><searchLink fieldCode="AU" term="%22Wei+F%22">Wei F</searchLink>; Division of Cancer Immunotherapy, Kanagawa Cancer Center Research Institute, Yokohama, Japan.; Cancer Vaccine and Immunotherapy Center, Kanagawa Cancer Center Research Institute, Yokohama, Japan.<br /><searchLink fieldCode="AU" term="%22Mano+Y%22">Mano Y</searchLink>; Division of Cancer Immunotherapy, Kanagawa Cancer Center Research Institute, Yokohama, Japan.; Cancer Vaccine and Immunotherapy Center, Kanagawa Cancer Center Research Institute, Yokohama, Japan.<br /><searchLink fieldCode="AU" term="%22Kouro+T%22">Kouro T</searchLink>; Division of Cancer Immunotherapy, Kanagawa Cancer Center Research Institute, Yokohama, Japan.; Cancer Vaccine and Immunotherapy Center, Kanagawa Cancer Center Research Institute, Yokohama, Japan.<br /><searchLink fieldCode="AU" term="%22Uehara+S%22">Uehara S</searchLink>; Department of Pediatric Surgery, Nihon University School of Medicine, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Sasada+T%22">Sasada T</searchLink>; Division of Cancer Immunotherapy, Kanagawa Cancer Center Research Institute, Yokohama, Japan.; Cancer Vaccine and Immunotherapy Center, Kanagawa Cancer Center Research Institute, Yokohama, Japan.
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      – TitleFull: Tumor-reactive TCRs within exhausted TILs reveal cancer type-specific immune landscapes in renal cell carcinoma.
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