Extending a liver-based model to lung and intestine: a comparative study of CYP1A1 and CYP1A2 induction by cigarette smoke in human in vitro models.

Saved in:
Bibliographic Details
Title: Extending a liver-based model to lung and intestine: a comparative study of CYP1A1 and CYP1A2 induction by cigarette smoke in human in vitro models.
Authors: Lenich AK; Department of Global Drug Metabolism and Pharmacokinetics, Boehringer Ingelheim Pharma GmbH & Co. KG, Birkendorfer Str. 65, 88397, Biberach an der Riss, Germany., Kishimoto W; Department of Global Drug Metabolism and Pharmacokinetics, Nippon Boehringer Ingelheim Co., Ltd, 6-7-5 Minatojima-Minamimachi, Chuo-ku, Kobe, 650-0047, Japan., Nakase H; Division of Gastroenterology and Hepatology, Department of Internal Medicine, Sapporo Medical University School of Medicine, S-1, W-16, Chuo-ku, Sapporo, 060-8543, Japan., Inui T; Laboratory of Biochemistry and Molecular Biology, Graduate School of Pharmaceutical Sciences, The University of Osaka, 1-6 Yamadaoka, Suita, Osaka, 565-0871, Japan., Mizuguchi H; Laboratory of Biochemistry and Molecular Biology, Graduate School of Pharmaceutical Sciences, The University of Osaka, 1-6 Yamadaoka, Suita, Osaka, 565-0871, Japan.; Laboratory of Hepatocyte Regulation, National Institutes of Biomedical Innovation, Health and Nutrition, 7-6-8, Saito-Asagi, Ibaraki, Osaka, 567-0085, Japan.; The Center for Advanced Medical Engineering and Informatics, The University of Osaka, 1-6 Yamadaoka, Suita, Osaka, 565-0871, Japan.; Institute for Open and Transdisciplinary Research Initiatives (OTRI), The University of Osaka, 1-6 Yamadaoka, Suita, Osaka, 565-0871, Japan., Ruez S; Department of Global Drug Metabolism and Pharmacokinetics, Boehringer Ingelheim Pharma GmbH & Co. KG, Birkendorfer Str. 65, 88397, Biberach an der Riss, Germany. stephanie.ruez@boehringer-ingelheim.com.
Source: Archives of toxicology [Arch Toxicol] 2026 May; Vol. 100 (5), pp. 2009-2014. Date of Electronic Publication: 2026 Feb 17.
Publication Type: Journal Article; Comparative Study
Journal Info: Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 0417615 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-0738 (Electronic) Linking ISSN: 03405761 NLM ISO Abbreviation: Arch Toxicol Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1432-0738
DOI:10.1007/s00204-026-04313-2