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Extending a liver-based model to lung and intestine: a comparative study of CYP1A1 and CYP1A2 induction by cigarette smoke in human in vitro models.

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Title: Extending a liver-based model to lung and intestine: a comparative study of CYP1A1 and CYP1A2 induction by cigarette smoke in human in vitro models.
Authors: Lenich AK; Department of Global Drug Metabolism and Pharmacokinetics, Boehringer Ingelheim Pharma GmbH & Co. KG, Birkendorfer Str. 65, 88397, Biberach an der Riss, Germany., Kishimoto W; Department of Global Drug Metabolism and Pharmacokinetics, Nippon Boehringer Ingelheim Co., Ltd, 6-7-5 Minatojima-Minamimachi, Chuo-ku, Kobe, 650-0047, Japan., Nakase H; Division of Gastroenterology and Hepatology, Department of Internal Medicine, Sapporo Medical University School of Medicine, S-1, W-16, Chuo-ku, Sapporo, 060-8543, Japan., Inui T; Laboratory of Biochemistry and Molecular Biology, Graduate School of Pharmaceutical Sciences, The University of Osaka, 1-6 Yamadaoka, Suita, Osaka, 565-0871, Japan., Mizuguchi H; Laboratory of Biochemistry and Molecular Biology, Graduate School of Pharmaceutical Sciences, The University of Osaka, 1-6 Yamadaoka, Suita, Osaka, 565-0871, Japan.; Laboratory of Hepatocyte Regulation, National Institutes of Biomedical Innovation, Health and Nutrition, 7-6-8, Saito-Asagi, Ibaraki, Osaka, 567-0085, Japan.; The Center for Advanced Medical Engineering and Informatics, The University of Osaka, 1-6 Yamadaoka, Suita, Osaka, 565-0871, Japan.; Institute for Open and Transdisciplinary Research Initiatives (OTRI), The University of Osaka, 1-6 Yamadaoka, Suita, Osaka, 565-0871, Japan., Ruez S; Department of Global Drug Metabolism and Pharmacokinetics, Boehringer Ingelheim Pharma GmbH & Co. KG, Birkendorfer Str. 65, 88397, Biberach an der Riss, Germany. stephanie.ruez@boehringer-ingelheim.com.
Source: Archives of toxicology [Arch Toxicol] 2026 May; Vol. 100 (5), pp. 2009-2014. Date of Electronic Publication: 2026 Feb 17.
Publication Type: Journal Article; Comparative Study
Journal Info: Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 0417615 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-0738 (Electronic) Linking ISSN: 03405761 NLM ISO Abbreviation: Arch Toxicol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Extending a liver-based model to lung and intestine: a comparative study of CYP1A1 and CYP1A2 induction by cigarette smoke in human in vitro models.
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  Data: <searchLink fieldCode="AU" term="%22Lenich+AK%22">Lenich AK</searchLink>; Department of Global Drug Metabolism and Pharmacokinetics, Boehringer Ingelheim Pharma GmbH & Co. KG, Birkendorfer Str. 65, 88397, Biberach an der Riss, Germany.<br /><searchLink fieldCode="AU" term="%22Kishimoto+W%22">Kishimoto W</searchLink>; Department of Global Drug Metabolism and Pharmacokinetics, Nippon Boehringer Ingelheim Co., Ltd, 6-7-5 Minatojima-Minamimachi, Chuo-ku, Kobe, 650-0047, Japan.<br /><searchLink fieldCode="AU" term="%22Nakase+H%22">Nakase H</searchLink>; Division of Gastroenterology and Hepatology, Department of Internal Medicine, Sapporo Medical University School of Medicine, S-1, W-16, Chuo-ku, Sapporo, 060-8543, Japan.<br /><searchLink fieldCode="AU" term="%22Inui+T%22">Inui T</searchLink>; Laboratory of Biochemistry and Molecular Biology, Graduate School of Pharmaceutical Sciences, The University of Osaka, 1-6 Yamadaoka, Suita, Osaka, 565-0871, Japan.<br /><searchLink fieldCode="AU" term="%22Mizuguchi+H%22">Mizuguchi H</searchLink>; Laboratory of Biochemistry and Molecular Biology, Graduate School of Pharmaceutical Sciences, The University of Osaka, 1-6 Yamadaoka, Suita, Osaka, 565-0871, Japan.; Laboratory of Hepatocyte Regulation, National Institutes of Biomedical Innovation, Health and Nutrition, 7-6-8, Saito-Asagi, Ibaraki, Osaka, 567-0085, Japan.; The Center for Advanced Medical Engineering and Informatics, The University of Osaka, 1-6 Yamadaoka, Suita, Osaka, 565-0871, Japan.; Institute for Open and Transdisciplinary Research Initiatives (OTRI), The University of Osaka, 1-6 Yamadaoka, Suita, Osaka, 565-0871, Japan.<br /><searchLink fieldCode="AU" term="%22Ruez+S%22">Ruez S</searchLink>; Department of Global Drug Metabolism and Pharmacokinetics, Boehringer Ingelheim Pharma GmbH & Co. KG, Birkendorfer Str. 65, 88397, Biberach an der Riss, Germany. stephanie.ruez@boehringer-ingelheim.com.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Springer-Verlag%22">Springer-Verlag </searchLink><i>Country of Publication: </i>Germany <i>NLM ID: </i>0417615 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1432-0738 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2203405761%22">03405761 </searchLink><i>NLM ISO Abbreviation: </i>Arch Toxicol <i>Subsets: </i>MEDLINE
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        Value: 10.1007/s00204-026-04313-2
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              Text: 2026 May
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