A potent inhibitor of PAI-1, MDI-2517, mitigates disease severity in a preclinical systemic sclerosis model.

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Title: A potent inhibitor of PAI-1, MDI-2517, mitigates disease severity in a preclinical systemic sclerosis model.
Authors: Su EJ; Division of Cardiovascular Medicine, Department of Internal Medicine., Tsou PS; Scleroderma Program, Division of Rheumatology, Department of Internal Medicine., Warnock M; Division of Cardiovascular Medicine, Department of Internal Medicine., Subbotina N; Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine., Mann K; Division of Cardiovascular Medicine, Department of Internal Medicine., Vichaikul S; Scleroderma Program, Division of Rheumatology, Department of Internal Medicine., Rosek A; Scleroderma Program, Division of Rheumatology, Department of Internal Medicine., Leung L; Department of Molecular Integrative Physiology; and., Xing X; Department of Dermatology; University of Michigan Medical School, Ann Arbor, Michigan, USA., Xing E; Department of Dermatology; University of Michigan Medical School, Ann Arbor, Michigan, USA., Plazyo O; Department of Dermatology; University of Michigan Medical School, Ann Arbor, Michigan, USA., Bogle R; Department of Dermatology; University of Michigan Medical School, Ann Arbor, Michigan, USA., Tsoi LC; Department of Dermatology; University of Michigan Medical School, Ann Arbor, Michigan, USA., Emal CD; Department of Chemistry, Eastern Michigan University, Ypsilanti, Michigan, USA., Khanna D; Scleroderma Program, Division of Rheumatology, Department of Internal Medicine., Varga J; Scleroderma Program, Division of Rheumatology, Department of Internal Medicine., Sisson TH; Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine., Gudjonsson JE; Scleroderma Program, Division of Rheumatology, Department of Internal Medicine.; Department of Dermatology; University of Michigan Medical School, Ann Arbor, Michigan, USA., Lawrence DA; Division of Cardiovascular Medicine, Department of Internal Medicine.
Source: JCI insight [JCI Insight] 2026 Feb 17; Vol. 11 (7). Date of Electronic Publication: 2026 Feb 17 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 101676073 Publication Model: eCollection Cited Medium: Internet ISSN: 2379-3708 (Electronic) Linking ISSN: 23793708 NLM ISO Abbreviation: JCI Insight Subsets: MEDLINE; In Process
Database: MEDLINE Ultimate
Description
ISSN:2379-3708
DOI:10.1172/jci.insight.195005