View in EDS

A potent inhibitor of PAI-1, MDI-2517, mitigates disease severity in a preclinical systemic sclerosis model.

Saved in:
Bibliographic Details
Title: A potent inhibitor of PAI-1, MDI-2517, mitigates disease severity in a preclinical systemic sclerosis model.
Authors: Su EJ; Division of Cardiovascular Medicine, Department of Internal Medicine., Tsou PS; Scleroderma Program, Division of Rheumatology, Department of Internal Medicine., Warnock M; Division of Cardiovascular Medicine, Department of Internal Medicine., Subbotina N; Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine., Mann K; Division of Cardiovascular Medicine, Department of Internal Medicine., Vichaikul S; Scleroderma Program, Division of Rheumatology, Department of Internal Medicine., Rosek A; Scleroderma Program, Division of Rheumatology, Department of Internal Medicine., Leung L; Department of Molecular Integrative Physiology; and., Xing X; Department of Dermatology; University of Michigan Medical School, Ann Arbor, Michigan, USA., Xing E; Department of Dermatology; University of Michigan Medical School, Ann Arbor, Michigan, USA., Plazyo O; Department of Dermatology; University of Michigan Medical School, Ann Arbor, Michigan, USA., Bogle R; Department of Dermatology; University of Michigan Medical School, Ann Arbor, Michigan, USA., Tsoi LC; Department of Dermatology; University of Michigan Medical School, Ann Arbor, Michigan, USA., Emal CD; Department of Chemistry, Eastern Michigan University, Ypsilanti, Michigan, USA., Khanna D; Scleroderma Program, Division of Rheumatology, Department of Internal Medicine., Varga J; Scleroderma Program, Division of Rheumatology, Department of Internal Medicine., Sisson TH; Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine., Gudjonsson JE; Scleroderma Program, Division of Rheumatology, Department of Internal Medicine.; Department of Dermatology; University of Michigan Medical School, Ann Arbor, Michigan, USA., Lawrence DA; Division of Cardiovascular Medicine, Department of Internal Medicine.
Source: JCI insight [JCI Insight] 2026 Feb 17; Vol. 11 (7). Date of Electronic Publication: 2026 Feb 17 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 101676073 Publication Model: eCollection Cited Medium: Internet ISSN: 2379-3708 (Electronic) Linking ISSN: 23793708 NLM ISO Abbreviation: JCI Insight Subsets: MEDLINE; In Process
Database: MEDLINE Ultimate
FullText Text:
  Availability: 0
Header DbId: mdl
DbLabel: MEDLINE Ultimate
An: 41701900
AccessLevel: 2
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: A potent inhibitor of PAI-1, MDI-2517, mitigates disease severity in a preclinical systemic sclerosis model.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AU" term="%22Su+EJ%22">Su EJ</searchLink>; Division of Cardiovascular Medicine, Department of Internal Medicine.<br /><searchLink fieldCode="AU" term="%22Tsou+PS%22">Tsou PS</searchLink>; Scleroderma Program, Division of Rheumatology, Department of Internal Medicine.<br /><searchLink fieldCode="AU" term="%22Warnock+M%22">Warnock M</searchLink>; Division of Cardiovascular Medicine, Department of Internal Medicine.<br /><searchLink fieldCode="AU" term="%22Subbotina+N%22">Subbotina N</searchLink>; Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine.<br /><searchLink fieldCode="AU" term="%22Mann+K%22">Mann K</searchLink>; Division of Cardiovascular Medicine, Department of Internal Medicine.<br /><searchLink fieldCode="AU" term="%22Vichaikul+S%22">Vichaikul S</searchLink>; Scleroderma Program, Division of Rheumatology, Department of Internal Medicine.<br /><searchLink fieldCode="AU" term="%22Rosek+A%22">Rosek A</searchLink>; Scleroderma Program, Division of Rheumatology, Department of Internal Medicine.<br /><searchLink fieldCode="AU" term="%22Leung+L%22">Leung L</searchLink>; Department of Molecular Integrative Physiology; and.<br /><searchLink fieldCode="AU" term="%22Xing+X%22">Xing X</searchLink>; Department of Dermatology; University of Michigan Medical School, Ann Arbor, Michigan, USA.<br /><searchLink fieldCode="AU" term="%22Xing+E%22">Xing E</searchLink>; Department of Dermatology; University of Michigan Medical School, Ann Arbor, Michigan, USA.<br /><searchLink fieldCode="AU" term="%22Plazyo+O%22">Plazyo O</searchLink>; Department of Dermatology; University of Michigan Medical School, Ann Arbor, Michigan, USA.<br /><searchLink fieldCode="AU" term="%22Bogle+R%22">Bogle R</searchLink>; Department of Dermatology; University of Michigan Medical School, Ann Arbor, Michigan, USA.<br /><searchLink fieldCode="AU" term="%22Tsoi+LC%22">Tsoi LC</searchLink>; Department of Dermatology; University of Michigan Medical School, Ann Arbor, Michigan, USA.<br /><searchLink fieldCode="AU" term="%22Emal+CD%22">Emal CD</searchLink>; Department of Chemistry, Eastern Michigan University, Ypsilanti, Michigan, USA.<br /><searchLink fieldCode="AU" term="%22Khanna+D%22">Khanna D</searchLink>; Scleroderma Program, Division of Rheumatology, Department of Internal Medicine.<br /><searchLink fieldCode="AU" term="%22Varga+J%22">Varga J</searchLink>; Scleroderma Program, Division of Rheumatology, Department of Internal Medicine.<br /><searchLink fieldCode="AU" term="%22Sisson+TH%22">Sisson TH</searchLink>; Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine.<br /><searchLink fieldCode="AU" term="%22Gudjonsson+JE%22">Gudjonsson JE</searchLink>; Scleroderma Program, Division of Rheumatology, Department of Internal Medicine.; Department of Dermatology; University of Michigan Medical School, Ann Arbor, Michigan, USA.<br /><searchLink fieldCode="AU" term="%22Lawrence+DA%22">Lawrence DA</searchLink>; Division of Cardiovascular Medicine, Department of Internal Medicine.
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22101676073%22">JCI insight</searchLink> [JCI Insight] 2026 Feb 17; Vol. 11 (7). <i>Date of Electronic Publication: </i>2026 Feb 17 (<i>Print Publication: </i>2026).
– Name: TypePub
  Label: Publication Type
  Group: TypPub
  Data: Journal Article
– Name: TitleSource
  Label: Journal Info
  Group: Src
  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Society+for+Clinical+Investigation%22">American Society for Clinical Investigation </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101676073 <i>Publication Model: </i>eCollection <i>Cited Medium: </i>Internet <i>ISSN: </i>2379-3708 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2223793708%22">23793708 </searchLink><i>NLM ISO Abbreviation: </i>JCI Insight <i>Subsets: </i>MEDLINE; In Process
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=41701900
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1172/jci.insight.195005
    Languages:
      – Code: eng
        Text: English
    Titles:
      – TitleFull: A potent inhibitor of PAI-1, MDI-2517, mitigates disease severity in a preclinical systemic sclerosis model.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Su EJ
      – PersonEntity:
          Name:
            NameFull: Tsou PS
      – PersonEntity:
          Name:
            NameFull: Warnock M
      – PersonEntity:
          Name:
            NameFull: Subbotina N
      – PersonEntity:
          Name:
            NameFull: Mann K
      – PersonEntity:
          Name:
            NameFull: Vichaikul S
      – PersonEntity:
          Name:
            NameFull: Rosek A
      – PersonEntity:
          Name:
            NameFull: Leung L
      – PersonEntity:
          Name:
            NameFull: Xing X
      – PersonEntity:
          Name:
            NameFull: Xing E
      – PersonEntity:
          Name:
            NameFull: Plazyo O
      – PersonEntity:
          Name:
            NameFull: Bogle R
      – PersonEntity:
          Name:
            NameFull: Tsoi LC
      – PersonEntity:
          Name:
            NameFull: Emal CD
      – PersonEntity:
          Name:
            NameFull: Khanna D
      – PersonEntity:
          Name:
            NameFull: Varga J
      – PersonEntity:
          Name:
            NameFull: Sisson TH
      – PersonEntity:
          Name:
            NameFull: Gudjonsson JE
      – PersonEntity:
          Name:
            NameFull: Lawrence DA
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 17
              M: 02
              Text: 2026 Feb 17
              Type: published
              Y: 2026
          Identifiers:
            – Type: issn-electronic
              Value: 2379-3708
          Numbering:
            – Type: volume
              Value: 11
            – Type: issue
              Value: 7
          Titles:
            – TitleFull: JCI insight
              Type: main
ResultId 1