Potent, Selective Pyrrolopyrimidine PDE11A4 Inhibitors with Improved Pharmaceutical Properties.

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Bibliographic Details
Title: Potent, Selective Pyrrolopyrimidine PDE11A4 Inhibitors with Improved Pharmaceutical Properties.
Authors: Mahmood SU; Department of Chemistry and Biochemistry, Sokol Institute of Pharmaceutical Life Sciences, Montclair State University, Montclair, New Jersey 07043, United States., Boddu RK; Department of Chemistry and Biochemistry, Sokol Institute of Pharmaceutical Life Sciences, Montclair State University, Montclair, New Jersey 07043, United States., Eberhard J; Biology Department, Boston College, Chestnut Hill, Massachusetts 02467, United States., Hoffman CS; Biology Department, Boston College, Chestnut Hill, Massachusetts 02467, United States., Gordon J; Moulder Center for Drug Discovery, Temple University, Philadelphia, Pennsylvania 19140, United States., Colussi D; Moulder Center for Drug Discovery, Temple University, Philadelphia, Pennsylvania 19140, United States., Childers W; Moulder Center for Drug Discovery, Temple University, Philadelphia, Pennsylvania 19140, United States., Amurrio E; Department of Neurobiology, University of Maryland School of Medicine, Center for Research on Aging, University of Maryland School of Medicine, Baltimore, Maryland 21201, United States., Danaher M; Department of Neurobiology, University of Maryland School of Medicine, Center for Research on Aging, University of Maryland School of Medicine, Baltimore, Maryland 21201, United States., Kelly MP; Department of Neurobiology, University of Maryland School of Medicine, Center for Research on Aging, University of Maryland School of Medicine, Baltimore, Maryland 21201, United States., Rotella DP; Department of Chemistry and Biochemistry, Sokol Institute of Pharmaceutical Life Sciences, Montclair State University, Montclair, New Jersey 07043, United States.
Source: ACS medicinal chemistry letters [ACS Med Chem Lett] 2026 Jan 30; Vol. 17 (2), pp. 547-553. Date of Electronic Publication: 2026 Jan 30 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101521073 Publication Model: eCollection Cited Medium: Print ISSN: 1948-5875 (Print) Linking ISSN: 19485875 NLM ISO Abbreviation: ACS Med Chem Lett Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1948-5875
DOI:10.1021/acsmedchemlett.5c00756