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Potent, Selective Pyrrolopyrimidine PDE11A4 Inhibitors with Improved Pharmaceutical Properties.

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Title: Potent, Selective Pyrrolopyrimidine PDE11A4 Inhibitors with Improved Pharmaceutical Properties.
Authors: Mahmood SU; Department of Chemistry and Biochemistry, Sokol Institute of Pharmaceutical Life Sciences, Montclair State University, Montclair, New Jersey 07043, United States., Boddu RK; Department of Chemistry and Biochemistry, Sokol Institute of Pharmaceutical Life Sciences, Montclair State University, Montclair, New Jersey 07043, United States., Eberhard J; Biology Department, Boston College, Chestnut Hill, Massachusetts 02467, United States., Hoffman CS; Biology Department, Boston College, Chestnut Hill, Massachusetts 02467, United States., Gordon J; Moulder Center for Drug Discovery, Temple University, Philadelphia, Pennsylvania 19140, United States., Colussi D; Moulder Center for Drug Discovery, Temple University, Philadelphia, Pennsylvania 19140, United States., Childers W; Moulder Center for Drug Discovery, Temple University, Philadelphia, Pennsylvania 19140, United States., Amurrio E; Department of Neurobiology, University of Maryland School of Medicine, Center for Research on Aging, University of Maryland School of Medicine, Baltimore, Maryland 21201, United States., Danaher M; Department of Neurobiology, University of Maryland School of Medicine, Center for Research on Aging, University of Maryland School of Medicine, Baltimore, Maryland 21201, United States., Kelly MP; Department of Neurobiology, University of Maryland School of Medicine, Center for Research on Aging, University of Maryland School of Medicine, Baltimore, Maryland 21201, United States., Rotella DP; Department of Chemistry and Biochemistry, Sokol Institute of Pharmaceutical Life Sciences, Montclair State University, Montclair, New Jersey 07043, United States.
Source: ACS medicinal chemistry letters [ACS Med Chem Lett] 2026 Jan 30; Vol. 17 (2), pp. 547-553. Date of Electronic Publication: 2026 Jan 30 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101521073 Publication Model: eCollection Cited Medium: Print ISSN: 1948-5875 (Print) Linking ISSN: 19485875 NLM ISO Abbreviation: ACS Med Chem Lett Subsets: PubMed not MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Mahmood+SU%22">Mahmood SU</searchLink>; Department of Chemistry and Biochemistry, Sokol Institute of Pharmaceutical Life Sciences, Montclair State University, Montclair, New Jersey 07043, United States.<br /><searchLink fieldCode="AU" term="%22Boddu+RK%22">Boddu RK</searchLink>; Department of Chemistry and Biochemistry, Sokol Institute of Pharmaceutical Life Sciences, Montclair State University, Montclair, New Jersey 07043, United States.<br /><searchLink fieldCode="AU" term="%22Eberhard+J%22">Eberhard J</searchLink>; Biology Department, Boston College, Chestnut Hill, Massachusetts 02467, United States.<br /><searchLink fieldCode="AU" term="%22Hoffman+CS%22">Hoffman CS</searchLink>; Biology Department, Boston College, Chestnut Hill, Massachusetts 02467, United States.<br /><searchLink fieldCode="AU" term="%22Gordon+J%22">Gordon J</searchLink>; Moulder Center for Drug Discovery, Temple University, Philadelphia, Pennsylvania 19140, United States.<br /><searchLink fieldCode="AU" term="%22Colussi+D%22">Colussi D</searchLink>; Moulder Center for Drug Discovery, Temple University, Philadelphia, Pennsylvania 19140, United States.<br /><searchLink fieldCode="AU" term="%22Childers+W%22">Childers W</searchLink>; Moulder Center for Drug Discovery, Temple University, Philadelphia, Pennsylvania 19140, United States.<br /><searchLink fieldCode="AU" term="%22Amurrio+E%22">Amurrio E</searchLink>; Department of Neurobiology, University of Maryland School of Medicine, Center for Research on Aging, University of Maryland School of Medicine, Baltimore, Maryland 21201, United States.<br /><searchLink fieldCode="AU" term="%22Danaher+M%22">Danaher M</searchLink>; Department of Neurobiology, University of Maryland School of Medicine, Center for Research on Aging, University of Maryland School of Medicine, Baltimore, Maryland 21201, United States.<br /><searchLink fieldCode="AU" term="%22Kelly+MP%22">Kelly MP</searchLink>; Department of Neurobiology, University of Maryland School of Medicine, Center for Research on Aging, University of Maryland School of Medicine, Baltimore, Maryland 21201, United States.<br /><searchLink fieldCode="AU" term="%22Rotella+DP%22">Rotella DP</searchLink>; Department of Chemistry and Biochemistry, Sokol Institute of Pharmaceutical Life Sciences, Montclair State University, Montclair, New Jersey 07043, United States.
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  Data: <searchLink fieldCode="JN" term="%22101521073%22">ACS medicinal chemistry letters</searchLink> [ACS Med Chem Lett] 2026 Jan 30; Vol. 17 (2), pp. 547-553. <i>Date of Electronic Publication: </i>2026 Jan 30 (<i>Print Publication: </i>2026).
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        Value: 10.1021/acsmedchemlett.5c00756
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              Text: 2026 Jan 30
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