Interferon-Driven Tryptophan Metabolism Links Inflammation and Mental Health in Juvenile Dermatomyositis.

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Title: Interferon-Driven Tryptophan Metabolism Links Inflammation and Mental Health in Juvenile Dermatomyositis.
Authors: Wu Y; Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC-DID), Ministry of Science & Technology, State Key Laboratory of Complex Severe and Rare Diseases, Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, Beijing, China.; Division of Rheumatology, University of Washington, Seattle, WA, USA., Levy AL; Seattle Children's Hospital and Research Center, University of Washington, Seattle, WA, USA.; Rady Children's Hospital, San Diego, CA, USA., Hermanson P; Division of Rheumatology, University of Washington, Seattle, WA, USA., Janappareddi A; Division of Rheumatology, University of Washington, Seattle, WA, USA., Wang T; Division of Rheumatology, University of Washington, Seattle, WA, USA., Gonzalez-Chapa JA; Division of Rheumatology, University of Washington, Seattle, WA, USA., Shi J; Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC-DID), Ministry of Science & Technology, State Key Laboratory of Complex Severe and Rare Diseases, Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, Beijing, China.; Division of Rheumatology, University of Washington, Seattle, WA, USA., Shenoi S; Seattle Children's Hospital and Research Center, University of Washington, Seattle, WA, USA., Li M; Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC-DID), Ministry of Science & Technology, State Key Laboratory of Complex Severe and Rare Diseases, Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, Beijing, China. mengtao.li@cstar.org.cn., Zeng X; Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC-DID), Ministry of Science & Technology, State Key Laboratory of Complex Severe and Rare Diseases, Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, Beijing, China. zengxfpumc@163.com., Lood C; Division of Rheumatology, University of Washington, Seattle, WA, USA. loodc@uw.edu.
Source: Inflammation [Inflammation] 2026 Feb 19; Vol. 49 (1). Date of Electronic Publication: 2026 Feb 19.
Publication Type: Journal Article
Journal Info: Publisher: Kluwer Academic/Plenum Publishers Country of Publication: United States NLM ID: 7600105 Publication Model: Electronic Cited Medium: Internet ISSN: 1573-2576 (Electronic) Linking ISSN: 03603997 NLM ISO Abbreviation: Inflammation Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1573-2576
DOI:10.1007/s10753-026-02469-8