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Interferon-Driven Tryptophan Metabolism Links Inflammation and Mental Health in Juvenile Dermatomyositis.

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Title: Interferon-Driven Tryptophan Metabolism Links Inflammation and Mental Health in Juvenile Dermatomyositis.
Authors: Wu Y; Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC-DID), Ministry of Science & Technology, State Key Laboratory of Complex Severe and Rare Diseases, Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, Beijing, China.; Division of Rheumatology, University of Washington, Seattle, WA, USA., Levy AL; Seattle Children's Hospital and Research Center, University of Washington, Seattle, WA, USA.; Rady Children's Hospital, San Diego, CA, USA., Hermanson P; Division of Rheumatology, University of Washington, Seattle, WA, USA., Janappareddi A; Division of Rheumatology, University of Washington, Seattle, WA, USA., Wang T; Division of Rheumatology, University of Washington, Seattle, WA, USA., Gonzalez-Chapa JA; Division of Rheumatology, University of Washington, Seattle, WA, USA., Shi J; Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC-DID), Ministry of Science & Technology, State Key Laboratory of Complex Severe and Rare Diseases, Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, Beijing, China.; Division of Rheumatology, University of Washington, Seattle, WA, USA., Shenoi S; Seattle Children's Hospital and Research Center, University of Washington, Seattle, WA, USA., Li M; Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC-DID), Ministry of Science & Technology, State Key Laboratory of Complex Severe and Rare Diseases, Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, Beijing, China. mengtao.li@cstar.org.cn., Zeng X; Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC-DID), Ministry of Science & Technology, State Key Laboratory of Complex Severe and Rare Diseases, Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, Beijing, China. zengxfpumc@163.com., Lood C; Division of Rheumatology, University of Washington, Seattle, WA, USA. loodc@uw.edu.
Source: Inflammation [Inflammation] 2026 Feb 19; Vol. 49 (1). Date of Electronic Publication: 2026 Feb 19.
Publication Type: Journal Article
Journal Info: Publisher: Kluwer Academic/Plenum Publishers Country of Publication: United States NLM ID: 7600105 Publication Model: Electronic Cited Medium: Internet ISSN: 1573-2576 (Electronic) Linking ISSN: 03603997 NLM ISO Abbreviation: Inflammation Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Interferon-Driven Tryptophan Metabolism Links Inflammation and Mental Health in Juvenile Dermatomyositis.
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  Data: <searchLink fieldCode="AU" term="%22Wu+Y%22">Wu Y</searchLink>; Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC-DID), Ministry of Science & Technology, State Key Laboratory of Complex Severe and Rare Diseases, Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, Beijing, China.; Division of Rheumatology, University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Levy+AL%22">Levy AL</searchLink>; Seattle Children's Hospital and Research Center, University of Washington, Seattle, WA, USA.; Rady Children's Hospital, San Diego, CA, USA.<br /><searchLink fieldCode="AU" term="%22Hermanson+P%22">Hermanson P</searchLink>; Division of Rheumatology, University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Janappareddi+A%22">Janappareddi A</searchLink>; Division of Rheumatology, University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Wang+T%22">Wang T</searchLink>; Division of Rheumatology, University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Gonzalez-Chapa+JA%22">Gonzalez-Chapa JA</searchLink>; Division of Rheumatology, University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Shi+J%22">Shi J</searchLink>; Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC-DID), Ministry of Science & Technology, State Key Laboratory of Complex Severe and Rare Diseases, Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, Beijing, China.; Division of Rheumatology, University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Shenoi+S%22">Shenoi S</searchLink>; Seattle Children's Hospital and Research Center, University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Li+M%22">Li M</searchLink>; Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC-DID), Ministry of Science & Technology, State Key Laboratory of Complex Severe and Rare Diseases, Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, Beijing, China. mengtao.li@cstar.org.cn.<br /><searchLink fieldCode="AU" term="%22Zeng+X%22">Zeng X</searchLink>; Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC-DID), Ministry of Science & Technology, State Key Laboratory of Complex Severe and Rare Diseases, Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, Beijing, China. zengxfpumc@163.com.<br /><searchLink fieldCode="AU" term="%22Lood+C%22">Lood C</searchLink>; Division of Rheumatology, University of Washington, Seattle, WA, USA. loodc@uw.edu.
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              Text: 2026 Feb 19
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