The glycolytic enzyme PFKM promotes renal fibrosis by activating the NF-κB pathway via lactate-mediated H3K18 lactylation.
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| Title: | The glycolytic enzyme PFKM promotes renal fibrosis by activating the NF-κB pathway via lactate-mediated H3K18 lactylation. |
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| Authors: | Chen Y; Department of Nephrology, The First Affiliated Hospital of Anhui, University of Chinese Medicine, Meishan Road 117, Shushang District, Hefei, 230031, China., Wang W; Department of Nephrology, The First Affiliated Hospital of Anhui, University of Chinese Medicine, Meishan Road 117, Shushang District, Hefei, 230031, China., Cheng M; Department of Nephrology, The First Affiliated Hospital of Anhui, University of Chinese Medicine, Meishan Road 117, Shushang District, Hefei, 230031, China., Wei L; Department of Nephrology, The First Affiliated Hospital of Anhui, University of Chinese Medicine, Meishan Road 117, Shushang District, Hefei, 230031, China., Sang Y; Department of Nephrology, The First Affiliated Hospital of Anhui, University of Chinese Medicine, Meishan Road 117, Shushang District, Hefei, 230031, China., Gao Y; Department of Nephrology, The First Affiliated Hospital of Anhui, University of Chinese Medicine, Meishan Road 117, Shushang District, Hefei, 230031, China., Zhang W; Department of Nephrology, The First Affiliated Hospital of Anhui, University of Chinese Medicine, Meishan Road 117, Shushang District, Hefei, 230031, China., Zhang L; Department of Nephrology, The First Affiliated Hospital of Anhui, University of Chinese Medicine, Meishan Road 117, Shushang District, Hefei, 230031, China., Dai R; Department of Nephrology, The First Affiliated Hospital of Anhui, University of Chinese Medicine, Meishan Road 117, Shushang District, Hefei, 230031, China. azydairong@163.com., Wang Y; Department of Nephrology, The First Affiliated Hospital of Anhui, University of Chinese Medicine, Meishan Road 117, Shushang District, Hefei, 230031, China. wypwyp54@aliyun.com. |
| Source: | Cellular and molecular life sciences : CMLS [Cell Mol Life Sci] 2026 Feb 19; Vol. 83 (1). Date of Electronic Publication: 2026 Feb 19. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Springer Country of Publication: Switzerland NLM ID: 9705402 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-9071 (Electronic) Linking ISSN: 1420682X NLM ISO Abbreviation: Cell Mol Life Sci Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1420-9071 |
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| DOI: | 10.1007/s00018-026-06118-z |
