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The glycolytic enzyme PFKM promotes renal fibrosis by activating the NF-κB pathway via lactate-mediated H3K18 lactylation.

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Title: The glycolytic enzyme PFKM promotes renal fibrosis by activating the NF-κB pathway via lactate-mediated H3K18 lactylation.
Authors: Chen Y; Department of Nephrology, The First Affiliated Hospital of Anhui, University of Chinese Medicine, Meishan Road 117, Shushang District, Hefei, 230031, China., Wang W; Department of Nephrology, The First Affiliated Hospital of Anhui, University of Chinese Medicine, Meishan Road 117, Shushang District, Hefei, 230031, China., Cheng M; Department of Nephrology, The First Affiliated Hospital of Anhui, University of Chinese Medicine, Meishan Road 117, Shushang District, Hefei, 230031, China., Wei L; Department of Nephrology, The First Affiliated Hospital of Anhui, University of Chinese Medicine, Meishan Road 117, Shushang District, Hefei, 230031, China., Sang Y; Department of Nephrology, The First Affiliated Hospital of Anhui, University of Chinese Medicine, Meishan Road 117, Shushang District, Hefei, 230031, China., Gao Y; Department of Nephrology, The First Affiliated Hospital of Anhui, University of Chinese Medicine, Meishan Road 117, Shushang District, Hefei, 230031, China., Zhang W; Department of Nephrology, The First Affiliated Hospital of Anhui, University of Chinese Medicine, Meishan Road 117, Shushang District, Hefei, 230031, China., Zhang L; Department of Nephrology, The First Affiliated Hospital of Anhui, University of Chinese Medicine, Meishan Road 117, Shushang District, Hefei, 230031, China., Dai R; Department of Nephrology, The First Affiliated Hospital of Anhui, University of Chinese Medicine, Meishan Road 117, Shushang District, Hefei, 230031, China. azydairong@163.com., Wang Y; Department of Nephrology, The First Affiliated Hospital of Anhui, University of Chinese Medicine, Meishan Road 117, Shushang District, Hefei, 230031, China. wypwyp54@aliyun.com.
Source: Cellular and molecular life sciences : CMLS [Cell Mol Life Sci] 2026 Feb 19; Vol. 83 (1). Date of Electronic Publication: 2026 Feb 19.
Publication Type: Journal Article
Journal Info: Publisher: Springer Country of Publication: Switzerland NLM ID: 9705402 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-9071 (Electronic) Linking ISSN: 1420682X NLM ISO Abbreviation: Cell Mol Life Sci Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: The glycolytic enzyme PFKM promotes renal fibrosis by activating the NF-κB pathway via lactate-mediated H3K18 lactylation.
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  Data: <searchLink fieldCode="AU" term="%22Chen+Y%22">Chen Y</searchLink>; Department of Nephrology, The First Affiliated Hospital of Anhui, University of Chinese Medicine, Meishan Road 117, Shushang District, Hefei, 230031, China.<br /><searchLink fieldCode="AU" term="%22Wang+W%22">Wang W</searchLink>; Department of Nephrology, The First Affiliated Hospital of Anhui, University of Chinese Medicine, Meishan Road 117, Shushang District, Hefei, 230031, China.<br /><searchLink fieldCode="AU" term="%22Cheng+M%22">Cheng M</searchLink>; Department of Nephrology, The First Affiliated Hospital of Anhui, University of Chinese Medicine, Meishan Road 117, Shushang District, Hefei, 230031, China.<br /><searchLink fieldCode="AU" term="%22Wei+L%22">Wei L</searchLink>; Department of Nephrology, The First Affiliated Hospital of Anhui, University of Chinese Medicine, Meishan Road 117, Shushang District, Hefei, 230031, China.<br /><searchLink fieldCode="AU" term="%22Sang+Y%22">Sang Y</searchLink>; Department of Nephrology, The First Affiliated Hospital of Anhui, University of Chinese Medicine, Meishan Road 117, Shushang District, Hefei, 230031, China.<br /><searchLink fieldCode="AU" term="%22Gao+Y%22">Gao Y</searchLink>; Department of Nephrology, The First Affiliated Hospital of Anhui, University of Chinese Medicine, Meishan Road 117, Shushang District, Hefei, 230031, China.<br /><searchLink fieldCode="AU" term="%22Zhang+W%22">Zhang W</searchLink>; Department of Nephrology, The First Affiliated Hospital of Anhui, University of Chinese Medicine, Meishan Road 117, Shushang District, Hefei, 230031, China.<br /><searchLink fieldCode="AU" term="%22Zhang+L%22">Zhang L</searchLink>; Department of Nephrology, The First Affiliated Hospital of Anhui, University of Chinese Medicine, Meishan Road 117, Shushang District, Hefei, 230031, China.<br /><searchLink fieldCode="AU" term="%22Dai+R%22">Dai R</searchLink>; Department of Nephrology, The First Affiliated Hospital of Anhui, University of Chinese Medicine, Meishan Road 117, Shushang District, Hefei, 230031, China. azydairong@163.com.<br /><searchLink fieldCode="AU" term="%22Wang+Y%22">Wang Y</searchLink>; Department of Nephrology, The First Affiliated Hospital of Anhui, University of Chinese Medicine, Meishan Road 117, Shushang District, Hefei, 230031, China. wypwyp54@aliyun.com.
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  Data: <searchLink fieldCode="JN" term="%229705402%22">Cellular and molecular life sciences : CMLS</searchLink> [Cell Mol Life Sci] 2026 Feb 19; Vol. 83 (1). <i>Date of Electronic Publication: </i>2026 Feb 19.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Springer%22">Springer </searchLink><i>Country of Publication: </i>Switzerland <i>NLM ID: </i>9705402 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1420-9071 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%221420682X%22">1420682X </searchLink><i>NLM ISO Abbreviation: </i>Cell Mol Life Sci <i>Subsets: </i>MEDLINE
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              Text: 2026 Feb 19
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