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Treatment for Brain Metastases With Stereotactic Radiation vs Hippocampal-Avoidance Whole Brain Radiation: A Randomized Clinical Trial.

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Title: Treatment for Brain Metastases With Stereotactic Radiation vs Hippocampal-Avoidance Whole Brain Radiation: A Randomized Clinical Trial.
Authors: Aizer AA; Department of Radiation Oncology, Brigham and Women's Hospital, Dana-Farber Cancer Institute, Boston, Massachusetts., Shin KY; Department of Data Science, Dana-Farber Cancer Institute, Boston, Massachusetts., Catalano PJ; Department of Data Science, Dana-Farber Cancer Institute, Boston, Massachusetts.; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, Massachusetts., Ricca I; Department of Radiation Oncology, Brigham and Women's Hospital, Dana-Farber Cancer Institute, Boston, Massachusetts., Johnson M; Department of Radiation Oncology, Brigham and Women's Hospital, Dana-Farber Cancer Institute, Boston, Massachusetts., Benham G; Department of Radiation Oncology, Brigham and Women's Hospital, Dana-Farber Cancer Institute, Boston, Massachusetts., Roper K; Department of Radiation Oncology, Milford Regional Medical Center, Milford, Massachusetts.; Department of Radiation Oncology, South Shore Health, Weymouth, Massachusetts., Spicer B; Department of Radiation Oncology, Brigham and Women's Hospital, Dana-Farber Cancer Institute, Boston, Massachusetts., Mann E; Department of Radiation Oncology, Brigham and Women's Hospital, Dana-Farber Cancer Institute, Boston, Massachusetts., Nosker J; Department of Neurology, Brigham and Women's Hospital, Boston, Massachusetts., Parsons MW; Department of Psychiatry, Massachusetts General Hospital, Boston., Mendu ML; Population Health Services Organization, Mass General Brigham, Boston, Massachusetts., Hepel J; Department of Radiation Oncology, Rhode Island Hospital/Brown University, Providence., Chipidza F; Department of Radiation Oncology, Milford Regional Medical Center, Milford, Massachusetts.; Department of Radiation Oncology, South Shore Health, Weymouth, Massachusetts., Krishnan M; Department of Radiation Oncology, Milford Regional Medical Center, Milford, Massachusetts.; Department of Radiation Oncology, South Shore Health, Weymouth, Massachusetts., Shi DD; Department of Radiation Oncology, Brigham and Women's Hospital, Dana-Farber Cancer Institute, Boston, Massachusetts., Lamba N; Department of Radiation Oncology, Brigham and Women's Hospital, Dana-Farber Cancer Institute, Boston, Massachusetts., Pashtan I; Department of Radiation Oncology, Milford Regional Medical Center, Milford, Massachusetts.; Department of Radiation Oncology, South Shore Health, Weymouth, Massachusetts., Peng L; Department of Radiation Oncology, Milford Regional Medical Center, Milford, Massachusetts.; Department of Radiation Oncology, South Shore Health, Weymouth, Massachusetts., Alexander B; Valo Health, Lexington, Massachusetts., Brown PD; Department of Radiation Oncology, Mayo Clinic, Rochester, Minnesota., Wen PY; Center for Neuro-Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts., Haas-Kogan DA; Department of Radiation Oncology, Brigham and Women's Hospital, Dana-Farber Cancer Institute, Boston, Massachusetts., Rahman R; Department of Radiation Oncology, Brigham and Women's Hospital, Dana-Farber Cancer Institute, Boston, Massachusetts., Tanguturi S; Department of Radiation Oncology, Brigham and Women's Hospital, Dana-Farber Cancer Institute, Boston, Massachusetts.
Source: JAMA [JAMA] 2026 Apr 07; Vol. 335 (13), pp. 1127-1136.
Publication Type: Clinical Trial, Phase III; Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial
Journal Info: Publisher: American Medical Association Country of Publication: United States NLM ID: 7501160 Publication Model: Print Cited Medium: Internet ISSN: 1538-3598 (Electronic) Linking ISSN: 00987484 NLM ISO Abbreviation: JAMA Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Treatment for Brain Metastases With Stereotactic Radiation vs Hippocampal-Avoidance Whole Brain Radiation: A Randomized Clinical Trial.
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  Data: <searchLink fieldCode="AU" term="%22Aizer+AA%22">Aizer AA</searchLink>; Department of Radiation Oncology, Brigham and Women's Hospital, Dana-Farber Cancer Institute, Boston, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Shin+KY%22">Shin KY</searchLink>; Department of Data Science, Dana-Farber Cancer Institute, Boston, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Catalano+PJ%22">Catalano PJ</searchLink>; Department of Data Science, Dana-Farber Cancer Institute, Boston, Massachusetts.; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Ricca+I%22">Ricca I</searchLink>; Department of Radiation Oncology, Brigham and Women's Hospital, Dana-Farber Cancer Institute, Boston, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Johnson+M%22">Johnson M</searchLink>; Department of Radiation Oncology, Brigham and Women's Hospital, Dana-Farber Cancer Institute, Boston, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Benham+G%22">Benham G</searchLink>; Department of Radiation Oncology, Brigham and Women's Hospital, Dana-Farber Cancer Institute, Boston, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Roper+K%22">Roper K</searchLink>; Department of Radiation Oncology, Milford Regional Medical Center, Milford, Massachusetts.; Department of Radiation Oncology, South Shore Health, Weymouth, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Spicer+B%22">Spicer B</searchLink>; Department of Radiation Oncology, Brigham and Women's Hospital, Dana-Farber Cancer Institute, Boston, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Mann+E%22">Mann E</searchLink>; Department of Radiation Oncology, Brigham and Women's Hospital, Dana-Farber Cancer Institute, Boston, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Nosker+J%22">Nosker J</searchLink>; Department of Neurology, Brigham and Women's Hospital, Boston, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Parsons+MW%22">Parsons MW</searchLink>; Department of Psychiatry, Massachusetts General Hospital, Boston.<br /><searchLink fieldCode="AU" term="%22Mendu+ML%22">Mendu ML</searchLink>; Population Health Services Organization, Mass General Brigham, Boston, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Hepel+J%22">Hepel J</searchLink>; Department of Radiation Oncology, Rhode Island Hospital/Brown University, Providence.<br /><searchLink fieldCode="AU" term="%22Chipidza+F%22">Chipidza F</searchLink>; Department of Radiation Oncology, Milford Regional Medical Center, Milford, Massachusetts.; Department of Radiation Oncology, South Shore Health, Weymouth, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Krishnan+M%22">Krishnan M</searchLink>; Department of Radiation Oncology, Milford Regional Medical Center, Milford, Massachusetts.; Department of Radiation Oncology, South Shore Health, Weymouth, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Shi+DD%22">Shi DD</searchLink>; Department of Radiation Oncology, Brigham and Women's Hospital, Dana-Farber Cancer Institute, Boston, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Lamba+N%22">Lamba N</searchLink>; Department of Radiation Oncology, Brigham and Women's Hospital, Dana-Farber Cancer Institute, Boston, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Pashtan+I%22">Pashtan I</searchLink>; Department of Radiation Oncology, Milford Regional Medical Center, Milford, Massachusetts.; Department of Radiation Oncology, South Shore Health, Weymouth, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Peng+L%22">Peng L</searchLink>; Department of Radiation Oncology, Milford Regional Medical Center, Milford, Massachusetts.; Department of Radiation Oncology, South Shore Health, Weymouth, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Alexander+B%22">Alexander B</searchLink>; Valo Health, Lexington, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Brown+PD%22">Brown PD</searchLink>; Department of Radiation Oncology, Mayo Clinic, Rochester, Minnesota.<br /><searchLink fieldCode="AU" term="%22Wen+PY%22">Wen PY</searchLink>; Center for Neuro-Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Haas-Kogan+DA%22">Haas-Kogan DA</searchLink>; Department of Radiation Oncology, Brigham and Women's Hospital, Dana-Farber Cancer Institute, Boston, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Rahman+R%22">Rahman R</searchLink>; Department of Radiation Oncology, Brigham and Women's Hospital, Dana-Farber Cancer Institute, Boston, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Tanguturi+S%22">Tanguturi S</searchLink>; Department of Radiation Oncology, Brigham and Women's Hospital, Dana-Farber Cancer Institute, Boston, Massachusetts.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Medical+Association%22">American Medical Association </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>7501160 <i>Publication Model: </i>Print <i>Cited Medium: </i>Internet <i>ISSN: </i>1538-3598 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200987484%22">00987484 </searchLink><i>NLM ISO Abbreviation: </i>JAMA <i>Subsets: </i>MEDLINE
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