Hypofractionated split-course versus standard radiotherapy in frail older patients with head and neck squamous-cell carcinoma (ELAN-RT trial): a non-inferiority, multicentre, open-label, randomised controlled trial.

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Title: Hypofractionated split-course versus standard radiotherapy in frail older patients with head and neck squamous-cell carcinoma (ELAN-RT trial): a non-inferiority, multicentre, open-label, randomised controlled trial.
Authors: Ortholan C; Oncology and Radiotherapy Unit, Centre Hospitalier Princesse Grace, Monaco. Electronic address: cecile.ortholan@chpg.mc., Aupérin A; Biostatistics and Epidemiology Office, Gustave Roussy, Inserm U1018 Oncostat labelled Ligue Contre le Cancer, University Paris-Saclay, Villejuif, France., Tao Y; Oncology and Radiotherapy Unit, Institut Gustave Roussy, Villejuif, France., Renard S; Oncology and Radiotherapy Unit, Institut de Cancérologie de Lorraine, Nancy, France., Pointreau Y; Oncology and Radiotherapy Unit, Clinique Victor Hugo, Le Mans, France., Lafond C; Oncology and Radiotherapy Unit, Clinique Victor Hugo, Le Mans, France., Bera G; Oncology and Radiotherapy Unit, Centre Hospitalier de Bretagne Sud, Lorient, France., Boisselier P; Oncology and Radiotherapy Unit, CRLC Val d'Aurelle, Montpellier, France., Benezery K; Oncology and Radiotherapy Unit, Centre Antoine Lacassagne, Nice, France., Racadot S; Oncology and Radiotherapy Unit, Centre Leon Berard, Lyon, France., Huguet F; 10 Oncology and Radiotherapy Unit, Centre Hospitalier Universitaire Tenon APHP, Paris, France., Bollet M; Oncology and Radiotherapy Unit, Groupe hospitalier privé Ambroise Pare-Hartmann, Neuilly sur Seine, France., Braccini AL; Oncology and Radiotherapy Unit, Centre Azuréen de Cancérologie, Mougins, France., Khoury C; Oncology and Radiotherapy Unit, Centre de Radiothérapie Saint-Louis Croix-Rouge française, Toulon, France., Jacquot S; Oncology and Radiotherapy Unit, Centre de Cancérologie du Grand Montpellier, Montpellier, France., Villa J; Oncology and Radiotherapy Unit, Centre Hospitalier Universitaire, Grenoble, France., Martin L; Oncology and Radiotherapy Unit, Centre de radiothérapie Guillaume le Conquérent, Le Havre, France., Di Rito A; Oncology and Radiotherapy Unit, Centre Medical de Forcilles, Férolles-Attilly, France., Wiazzane N; Oncology and Radiotherapy Unit, Institut de Cancérologie de l'Ouest, Centre René Gauducheau, Saint-Herblain, France., Goineau A; Oncology and Radiotherapy Unit, Centre Paul Papin, Angers, France., Dupin C; Oncology and Radiotherapy Unit, Centre Hospitalier Universitaire Saint André, Bordeaux, France., Cartier L; Oncology and Radiotherapy Unit, Institut Sainte-Catherine, Avignon, France., Ruffier A; Oncology and Radiotherapy Unit, Centre Hospitalier Universitaire Bretonneau-CORAD (Clinique d'Oncologie et de Radiothérapie), Tours, France., Cheurfa N; Biostatistics and Epidemiology Office, Gustave Roussy, Inserm U1018 Oncostat labelled Ligue Contre le Cancer, University Paris-Saclay, Villejuif, France., Schwob D; Biostatistics and Epidemiology Office, Gustave Roussy, Inserm U1018 Oncostat labelled Ligue Contre le Cancer, University Paris-Saclay, Villejuif, France., Mertens C; Oncogeriatrics Unit, Bergonié Institute, Bordeaux, France., Le Caer H; Medical Oncology Unit, Centre Hospitalier de Saint-Brieuc, France., Bourhis J; Radiotherapy Unit, Centre Hospitalier Universitaire de Vaudois, Lausanne, Switzerland., Guigay J; Université Côte d'Azur, Nice, France., Sun XS; Oncology and Radiotherapy Unit, CHRU de Besançon and Hôpital Nord France Comté, Montbéliard, France.
Corporate Authors: ELAN Group including Gustave Roussy, Unicancer GERICO and the H&N groups, and the GORTEC
Source: The lancet. Healthy longevity [Lancet Healthy Longev] 2026 Jan; Vol. 7 (1), pp. 100812. Date of Electronic Publication: 2026 Feb 16.
Publication Type: Journal Article; Randomized Controlled Trial; Multicenter Study; Equivalence Trial; Comparative Study
Journal Info: Publisher: Elsevier Ltd Country of Publication: England NLM ID: 101773309 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2666-7568 (Electronic) Linking ISSN: 26667568 NLM ISO Abbreviation: Lancet Healthy Longev Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2666-7568
DOI:10.1016/j.lanhl.2025.100812