Hypofractionated split-course versus standard radiotherapy in frail older patients with head and neck squamous-cell carcinoma (ELAN-RT trial): a non-inferiority, multicentre, open-label, randomised controlled trial.
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| Title: | Hypofractionated split-course versus standard radiotherapy in frail older patients with head and neck squamous-cell carcinoma (ELAN-RT trial): a non-inferiority, multicentre, open-label, randomised controlled trial. |
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| Authors: | Ortholan C; Oncology and Radiotherapy Unit, Centre Hospitalier Princesse Grace, Monaco. Electronic address: cecile.ortholan@chpg.mc., Aupérin A; Biostatistics and Epidemiology Office, Gustave Roussy, Inserm U1018 Oncostat labelled Ligue Contre le Cancer, University Paris-Saclay, Villejuif, France., Tao Y; Oncology and Radiotherapy Unit, Institut Gustave Roussy, Villejuif, France., Renard S; Oncology and Radiotherapy Unit, Institut de Cancérologie de Lorraine, Nancy, France., Pointreau Y; Oncology and Radiotherapy Unit, Clinique Victor Hugo, Le Mans, France., Lafond C; Oncology and Radiotherapy Unit, Clinique Victor Hugo, Le Mans, France., Bera G; Oncology and Radiotherapy Unit, Centre Hospitalier de Bretagne Sud, Lorient, France., Boisselier P; Oncology and Radiotherapy Unit, CRLC Val d'Aurelle, Montpellier, France., Benezery K; Oncology and Radiotherapy Unit, Centre Antoine Lacassagne, Nice, France., Racadot S; Oncology and Radiotherapy Unit, Centre Leon Berard, Lyon, France., Huguet F; 10 Oncology and Radiotherapy Unit, Centre Hospitalier Universitaire Tenon APHP, Paris, France., Bollet M; Oncology and Radiotherapy Unit, Groupe hospitalier privé Ambroise Pare-Hartmann, Neuilly sur Seine, France., Braccini AL; Oncology and Radiotherapy Unit, Centre Azuréen de Cancérologie, Mougins, France., Khoury C; Oncology and Radiotherapy Unit, Centre de Radiothérapie Saint-Louis Croix-Rouge française, Toulon, France., Jacquot S; Oncology and Radiotherapy Unit, Centre de Cancérologie du Grand Montpellier, Montpellier, France., Villa J; Oncology and Radiotherapy Unit, Centre Hospitalier Universitaire, Grenoble, France., Martin L; Oncology and Radiotherapy Unit, Centre de radiothérapie Guillaume le Conquérent, Le Havre, France., Di Rito A; Oncology and Radiotherapy Unit, Centre Medical de Forcilles, Férolles-Attilly, France., Wiazzane N; Oncology and Radiotherapy Unit, Institut de Cancérologie de l'Ouest, Centre René Gauducheau, Saint-Herblain, France., Goineau A; Oncology and Radiotherapy Unit, Centre Paul Papin, Angers, France., Dupin C; Oncology and Radiotherapy Unit, Centre Hospitalier Universitaire Saint André, Bordeaux, France., Cartier L; Oncology and Radiotherapy Unit, Institut Sainte-Catherine, Avignon, France., Ruffier A; Oncology and Radiotherapy Unit, Centre Hospitalier Universitaire Bretonneau-CORAD (Clinique d'Oncologie et de Radiothérapie), Tours, France., Cheurfa N; Biostatistics and Epidemiology Office, Gustave Roussy, Inserm U1018 Oncostat labelled Ligue Contre le Cancer, University Paris-Saclay, Villejuif, France., Schwob D; Biostatistics and Epidemiology Office, Gustave Roussy, Inserm U1018 Oncostat labelled Ligue Contre le Cancer, University Paris-Saclay, Villejuif, France., Mertens C; Oncogeriatrics Unit, Bergonié Institute, Bordeaux, France., Le Caer H; Medical Oncology Unit, Centre Hospitalier de Saint-Brieuc, France., Bourhis J; Radiotherapy Unit, Centre Hospitalier Universitaire de Vaudois, Lausanne, Switzerland., Guigay J; Université Côte d'Azur, Nice, France., Sun XS; Oncology and Radiotherapy Unit, CHRU de Besançon and Hôpital Nord France Comté, Montbéliard, France. |
| Corporate Authors: | ELAN Group including Gustave Roussy, Unicancer GERICO and the H&N groups, and the GORTEC |
| Source: | The lancet. Healthy longevity [Lancet Healthy Longev] 2026 Jan; Vol. 7 (1), pp. 100812. Date of Electronic Publication: 2026 Feb 16. |
| Publication Type: | Journal Article; Randomized Controlled Trial; Multicenter Study; Equivalence Trial; Comparative Study |
| Journal Info: | Publisher: Elsevier Ltd Country of Publication: England NLM ID: 101773309 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2666-7568 (Electronic) Linking ISSN: 26667568 NLM ISO Abbreviation: Lancet Healthy Longev Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 41713468 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Hypofractionated split-course versus standard radiotherapy in frail older patients with head and neck squamous-cell carcinoma (ELAN-RT trial): a non-inferiority, multicentre, open-label, randomised controlled trial. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Ortholan+C%22">Ortholan C</searchLink>; Oncology and Radiotherapy Unit, Centre Hospitalier Princesse Grace, Monaco. Electronic address: cecile.ortholan@chpg.mc.<br /><searchLink fieldCode="AU" term="%22Aupérin+A%22">Aupérin A</searchLink>; Biostatistics and Epidemiology Office, Gustave Roussy, Inserm U1018 Oncostat labelled Ligue Contre le Cancer, University Paris-Saclay, Villejuif, France.<br /><searchLink fieldCode="AU" term="%22Tao+Y%22">Tao Y</searchLink>; Oncology and Radiotherapy Unit, Institut Gustave Roussy, Villejuif, France.<br /><searchLink fieldCode="AU" term="%22Renard+S%22">Renard S</searchLink>; Oncology and Radiotherapy Unit, Institut de Cancérologie de Lorraine, Nancy, France.<br /><searchLink fieldCode="AU" term="%22Pointreau+Y%22">Pointreau Y</searchLink>; Oncology and Radiotherapy Unit, Clinique Victor Hugo, Le Mans, France.<br /><searchLink fieldCode="AU" term="%22Lafond+C%22">Lafond C</searchLink>; Oncology and Radiotherapy Unit, Clinique Victor Hugo, Le Mans, France.<br /><searchLink fieldCode="AU" term="%22Bera+G%22">Bera G</searchLink>; Oncology and Radiotherapy Unit, Centre Hospitalier de Bretagne Sud, Lorient, France.<br /><searchLink fieldCode="AU" term="%22Boisselier+P%22">Boisselier P</searchLink>; Oncology and Radiotherapy Unit, CRLC Val d'Aurelle, Montpellier, France.<br /><searchLink fieldCode="AU" term="%22Benezery+K%22">Benezery K</searchLink>; Oncology and Radiotherapy Unit, Centre Antoine Lacassagne, Nice, France.<br /><searchLink fieldCode="AU" term="%22Racadot+S%22">Racadot S</searchLink>; Oncology and Radiotherapy Unit, Centre Leon Berard, Lyon, France.<br /><searchLink fieldCode="AU" term="%22Huguet+F%22">Huguet F</searchLink>; 10 Oncology and Radiotherapy Unit, Centre Hospitalier Universitaire Tenon APHP, Paris, France.<br /><searchLink fieldCode="AU" term="%22Bollet+M%22">Bollet M</searchLink>; Oncology and Radiotherapy Unit, Groupe hospitalier privé Ambroise Pare-Hartmann, Neuilly sur Seine, France.<br /><searchLink fieldCode="AU" term="%22Braccini+AL%22">Braccini AL</searchLink>; Oncology and Radiotherapy Unit, Centre Azuréen de Cancérologie, Mougins, France.<br /><searchLink fieldCode="AU" term="%22Khoury+C%22">Khoury C</searchLink>; Oncology and Radiotherapy Unit, Centre de Radiothérapie Saint-Louis Croix-Rouge française, Toulon, France.<br /><searchLink fieldCode="AU" term="%22Jacquot+S%22">Jacquot S</searchLink>; Oncology and Radiotherapy Unit, Centre de Cancérologie du Grand Montpellier, Montpellier, France.<br /><searchLink fieldCode="AU" term="%22Villa+J%22">Villa J</searchLink>; Oncology and Radiotherapy Unit, Centre Hospitalier Universitaire, Grenoble, France.<br /><searchLink fieldCode="AU" term="%22Martin+L%22">Martin L</searchLink>; Oncology and Radiotherapy Unit, Centre de radiothérapie Guillaume le Conquérent, Le Havre, France.<br /><searchLink fieldCode="AU" term="%22Di+Rito+A%22">Di Rito A</searchLink>; Oncology and Radiotherapy Unit, Centre Medical de Forcilles, Férolles-Attilly, France.<br /><searchLink fieldCode="AU" term="%22Wiazzane+N%22">Wiazzane N</searchLink>; Oncology and Radiotherapy Unit, Institut de Cancérologie de l'Ouest, Centre René Gauducheau, Saint-Herblain, France.<br /><searchLink fieldCode="AU" term="%22Goineau+A%22">Goineau A</searchLink>; Oncology and Radiotherapy Unit, Centre Paul Papin, Angers, France.<br /><searchLink fieldCode="AU" term="%22Dupin+C%22">Dupin C</searchLink>; Oncology and Radiotherapy Unit, Centre Hospitalier Universitaire Saint André, Bordeaux, France.<br /><searchLink fieldCode="AU" term="%22Cartier+L%22">Cartier L</searchLink>; Oncology and Radiotherapy Unit, Institut Sainte-Catherine, Avignon, France.<br /><searchLink fieldCode="AU" term="%22Ruffier+A%22">Ruffier A</searchLink>; Oncology and Radiotherapy Unit, Centre Hospitalier Universitaire Bretonneau-CORAD (Clinique d'Oncologie et de Radiothérapie), Tours, France.<br /><searchLink fieldCode="AU" term="%22Cheurfa+N%22">Cheurfa N</searchLink>; Biostatistics and Epidemiology Office, Gustave Roussy, Inserm U1018 Oncostat labelled Ligue Contre le Cancer, University Paris-Saclay, Villejuif, France.<br /><searchLink fieldCode="AU" term="%22Schwob+D%22">Schwob D</searchLink>; Biostatistics and Epidemiology Office, Gustave Roussy, Inserm U1018 Oncostat labelled Ligue Contre le Cancer, University Paris-Saclay, Villejuif, France.<br /><searchLink fieldCode="AU" term="%22Mertens+C%22">Mertens C</searchLink>; Oncogeriatrics Unit, Bergonié Institute, Bordeaux, France.<br /><searchLink fieldCode="AU" term="%22Le+Caer+H%22">Le Caer H</searchLink>; Medical Oncology Unit, Centre Hospitalier de Saint-Brieuc, France.<br /><searchLink fieldCode="AU" term="%22Bourhis+J%22">Bourhis J</searchLink>; Radiotherapy Unit, Centre Hospitalier Universitaire de Vaudois, Lausanne, Switzerland.<br /><searchLink fieldCode="AU" term="%22Guigay+J%22">Guigay J</searchLink>; Université Côte d'Azur, Nice, France.<br /><searchLink fieldCode="AU" term="%22Sun+XS%22">Sun XS</searchLink>; Oncology and Radiotherapy Unit, CHRU de Besançon and Hôpital Nord France Comté, Montbéliard, France. – Name: AuthorCorporate Label: Corporate Authors Group: Au Data: <searchLink fieldCode="CA" term="%22ELAN+Group+including+Gustave+Roussy%2C+Unicancer+GERICO+and+the+H%26N+groups%2C+and+the+GORTEC%22">ELAN Group including Gustave Roussy, Unicancer GERICO and the H&N groups, and the GORTEC</searchLink> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22101773309%22">The lancet. Healthy longevity</searchLink> [Lancet Healthy Longev] 2026 Jan; Vol. 7 (1), pp. 100812. <i>Date of Electronic Publication: </i>2026 Feb 16. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article; Randomized Controlled Trial; Multicenter Study; Equivalence Trial; Comparative Study – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier+Ltd%22">Elsevier Ltd </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101773309 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2666-7568 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2226667568%22">26667568 </searchLink><i>NLM ISO Abbreviation: </i>Lancet Healthy Longev <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=41713468 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1016/j.lanhl.2025.100812 Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: 100812 Titles: – TitleFull: Hypofractionated split-course versus standard radiotherapy in frail older patients with head and neck squamous-cell carcinoma (ELAN-RT trial): a non-inferiority, multicentre, open-label, randomised controlled trial. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Ortholan C – PersonEntity: Name: NameFull: Aupérin A – PersonEntity: Name: NameFull: Tao Y – PersonEntity: Name: NameFull: Renard S – PersonEntity: Name: NameFull: Pointreau Y – PersonEntity: Name: NameFull: Lafond C – PersonEntity: Name: NameFull: Bera G – PersonEntity: Name: NameFull: Boisselier P – PersonEntity: Name: NameFull: Benezery K – PersonEntity: Name: NameFull: Racadot S – PersonEntity: Name: NameFull: Huguet F – PersonEntity: Name: NameFull: Bollet M – PersonEntity: Name: NameFull: Braccini AL – PersonEntity: Name: NameFull: Khoury C – PersonEntity: Name: NameFull: Jacquot S – PersonEntity: Name: NameFull: Villa J – PersonEntity: Name: NameFull: Martin L – PersonEntity: Name: NameFull: Di Rito A – PersonEntity: Name: NameFull: Wiazzane N – PersonEntity: Name: NameFull: Goineau A – PersonEntity: Name: NameFull: Dupin C – PersonEntity: Name: NameFull: Cartier L – PersonEntity: Name: NameFull: Ruffier A – PersonEntity: Name: NameFull: Cheurfa N – PersonEntity: Name: NameFull: Schwob D – PersonEntity: Name: NameFull: Mertens C – PersonEntity: Name: NameFull: Le Caer H – PersonEntity: Name: NameFull: Bourhis J – PersonEntity: Name: NameFull: Guigay J – PersonEntity: Name: NameFull: Sun XS IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 01 Text: 2026 Jan Type: published Y: 2026 Identifiers: – Type: issn-electronic Value: 2666-7568 Numbering: – Type: volume Value: 7 – Type: issue Value: 1 Titles: – TitleFull: The lancet. Healthy longevity Type: main |
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