ESMO adaptation of Lines of Systemic Therapy (EnLiST): a consensus framework for standardising the designation of lines of therapy in solid tumours.

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Title: ESMO adaptation of Lines of Systemic Therapy (EnLiST): a consensus framework for standardising the designation of lines of therapy in solid tumours.
Authors: Saini KS; Department of Medical Oncology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK., Koopman M; Department of Medical Oncology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands., Martins-Branco D; Scientific and Medical Division, European Society for Medical Oncology (ESMO), Lugano, Switzerland., Bossi P; Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy; IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy., Braendegaard Winther S; Department of Oncology, Odense University Hospital, Institute of Clinical Research, University of Southern Denmark, Denmark., Brahmi M; Department of Medical Oncology, Centre Léon Bérard, Lyon, France., Braña I; Head and Neck Cancer Group, Department of Medical Oncology, Vall d'Hebron University Hospital, Barcelona, Spain; Medical Oncology, Vall d'Hebron Institute of Oncology (VHIO), Hospital Universitari Vall d'Hebron, Vall d'Hebron Barcelona Hospital Campus, Barcelona, Spain., Calvo E; START Madrid-CIOCC, Centro Integral Oncológico Clara Campal, Madrid, Spain., Castelo-Branco L; NOVA Medical School, Faculdade de Ciências Médicas, NMS, FCM, Universidade NOVA de Lisboa, Lisbon, Portugal., Colombo I; Institute of Southern Switzerland (IOSI), Ente Ospedaliero Cantonale (EOC), Bellinzona, Switzerland., de Azambuja E; Université Libre de Bruxelles (ULB), Hôpital Universitaire de Bruxelles (H.U.B), Institut Jules Bordet, Medical Oncology Department, Brussels, Belgium., De Ruysscher D; Radiation Oncology (Maastro), Maastricht UMC+, GROW Research Institute for Oncology and Reproduction, Maastricht, The Netherlands; Erasmus MC Cancer Institute, University Medical Center Rotterdam, Department of Radiotherapy, Rotterdam, The Netherlands., Dienstmann R; Oncology Data Science Group, Vall d'Hebron Institute of Oncology, Barcelona, Spain., Dingemans AC; Department of Pulmonary Medicine, Erasmus MC Cancer Institute, University Medical Center, Rotterdam, The Netherlands., Ekholm M; Department of Oncology, Ryhov County Hospital, Jönköping, Sweden; Department of Biomedical and Clinical Sciences, Division of Surgery, Orthopedics and Oncology, Linköping University, Linköping, Sweden., Gallois C; Paris-Cité University, Department of Gastroenterology and Digestive Oncology, Georges Pompidou European Hospital, SIRIC CARPEM, Paris, France., Golfinopoulos V; EORTC Headquarters, Brussels, Belgium., Grande E; MD Anderson Cancer Center Madrid, Madrid, Spain., Halabi S; Department of Biostatistics and Bioinformatics, Duke University Medical Center, Durham, USA., Le Rhun E; Department of Neurosurgery, University Hospital Zurich, Zurich, Switzerland; Department of Neurology, University Hospital Zurich, Zurich, Switzerland; Department of Medical Oncology and Hematology, University Hospital Zurich, Zurich, Switzerland., Le Saux O; Department of Medical Oncology, Centre Léon Bérard, Lyon, France., Leighl NB; Division of Medical Oncology and Hematology, Princess Margaret Cancer Center, University Health Network, University of Toronto, Toronto, Canada., Lonardi S; Oncology Unit 1, Department of Oncology, Veneto Institute of Oncology IOV-IRCCS, Padua, Italy., Lorenzen S; TUM University Hospital, Rechts der Isar, Department of Medicine III, Munich, Germany., Lorusso D; Division of Gynecologic Oncology, Humanitas San Pio X Hospital, Milan, Italy; Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan., Minniti G; Department of Radiological Sciences, Oncology and Anatomical Pathology, Sapienza University of Rome, Rome, Italy; IRCCS Neuromed, Pozzilli, Italy., Mountzios G; Fourth Department of Medical Oncology and Clinical Trials Unit, Henry Dunant Hospital Center, Athens, Greece., Oldenburg J; Department of Oncology, Akershus University Hospital, Lørenskog, Norway., Oosting SF; Department of Medical Oncology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands., Osterlund P; Department of Oncology, Tampere University Hospital, Tampere, Finland; Department of Oncology, Karolinska University Hospital and Karolinska Institutet, Stockholm, Sweden., Perez-Gracia JL; Department of Oncology and Program in Immunology and Immunotherapy, CIMA-Universidad de Navarra, Cancer Center Clinica Universidad de Navarra (CCUN), Pamplona, Spain; Centro de Investigacion Biomédica en Red de Cancer (CIBERONC), Madrid, Spain; Navarra Institute for Health Research (IDISNA), Pamplona, Spain., Pellat A; Department of Gastroenterology, Endoscopy and Digestive Oncology, Assistance Publique-Hôpitaux de Paris, Cochin University Hospital, Paris, France., Piperno-Neumann S; Department of Medical Oncology, Institut Curie, Paris, France., Plummer R; Newcastle University and Newcastle Hospitals NHS Foundation Trust, Northern Centre for Cancer Care, Newcastle upon Tyne, UK., Porta C; Interdisciplinary Department of Medicine, University of Bari 'Aldo Moro', Bari, Italy; A.O.U. Consorziale Policlinico di Bari, Bari, Italy., Punie K; Department of Medical Oncology, Ziekenhuis Aan de Stroom, Antwerp, Belgium., Ray-Coquard I; Department of Medical Oncology, Centre Léon Bérard, Lyon, France., Remon J; Department of Cancer Medicine, Gustave Roussy, Villejuif, France., Ruhlmann CH; Department of Oncology, Odense University Hospital, Institute of Clinical Research, University of Southern Denmark, Denmark., Rutkowski P; Department of Soft Tissue/Bone Sarcoma and Melanoma, Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw, Poland., Siu LL; Division of Medical Oncology and Hematology, Princess Margaret Cancer Center, University Health Network, University of Toronto, Toronto, Canada., Stacchiotti S; Department of Cancer Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy., Suarez C; Medical Oncology, Vall d'Hebron Institute of Oncology (VHIO), Hospital Universitari Vall d'Hebron, Vall d'Hebron Barcelona Hospital Campus, Barcelona, Spain., Suijkerbuijk K; Department of Medical Oncology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands., Taieb J; Paris-Cité University, Department of Gastroenterology and Digestive Oncology, Georges Pompidou European Hospital, SIRIC CARPEM, Paris, France., Trapani D; Department of Oncology and Hemato-Oncology, Università degli Studi di Milano, Milan, Italy; Early Drug Development for Innovative Therapies Division, European Institute of Oncology, IRCCS, Milan, Italy., Valachis A; Department of Oncology, Faculty of Medicine and Health, Örebro University Hospital, Örebro University, Örebro, Sweden., van Laarhoven HWM; Department of Medical Oncology, Amsterdam UMC Location University of Amsterdam, Amsterdam, The Netherlands; Cancer Center Amsterdam, Cancer Treatment and Quality of Life, Amsterdam, The Netherlands., Vogel A; Department of Gastroenterology, Hepatology, Endocrinology and Infectious Diseases, Hannover Medical School, Hanover, Germany; Division of Gastroenterology and Hepatology, Toronto General Hospital, Medical Oncology, Princess Margaret Cancer Centre, Toronto, Canada., Zer A; Department of Medical Oncology, Rambam Health Care Campus, Rappaport Faculty of Medicine, Technion Institute of Technology, Haifa, Israel., Pentheroudakis G; Scientific and Medical Division, European Society for Medical Oncology (ESMO), Lugano, Switzerland., Delaloge S; Department of Cancer Medicine, Gustave Roussy, Villejuif, France., Twelves C; University of Leeds and Leeds Teaching Hospitals NHS Trust, Leeds, UK.
Source: Annals of oncology : official journal of the European Society for Medical Oncology [Ann Oncol] 2026 May; Vol. 37 (5), pp. 608-623. Date of Electronic Publication: 2026 Feb 17.
Publication Type: Journal Article; Consensus Statement; Practice Guideline
Journal Info: Publisher: Elsevier Country of Publication: England NLM ID: 9007735 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1569-8041 (Electronic) Linking ISSN: 09237534 NLM ISO Abbreviation: Ann Oncol Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1569-8041
DOI:10.1016/j.annonc.2026.02.008