ALDH2 inhibits head and neck tumorigenesis through RAS signaling suppression, transactivation of TGM2, and synergy with ALDH6A1.
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| Title: | ALDH2 inhibits head and neck tumorigenesis through RAS signaling suppression, transactivation of TGM2, and synergy with ALDH6A1. |
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| Authors: | Janesha UGS; Institute of Biomedical Sciences, College of Medicine, National Sun Yat-sen University, Kaohsiung, 80424, Taiwan.; Department of Medical Laboratory Science, Faculty of Allied Health Sciences, University of Ruhuna, Galle, 80000, Sri Lanka., Chiu CT; An Nan Hospital, China Medical University, Tainan, 70955, Taiwan., Tsai MH; Department of Otolaryngology, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, 83301, Taiwan.; Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Taoyuan, 33302, Taiwan.; School of Medicine, Chang Gung University College of Medicine, Taoyuan, 33302, Taiwan.; School of Medicine, College of Medicine, National Sun Yat-sen University, Kaohsiung, 80424, Taiwan., Chang KM; Department of Otolaryngology, Head and Neck Surgery, Pingtung Veterans General Hospital, Pingtung, 90090, Taiwan.; Department of Otolaryngology, Head and Neck Surgery, Kaohsiung Veterans General Hospital, Kaohsiung, 83301, Taiwan., Chien CY; Department of Otolaryngology, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, 83301, Taiwan.; Doctoral Program of Clinical and Experimental Medicine, College of Medicine, National Sun Yat-sen University, Kaohsiung, 80424, Taiwan., Huang HS; Department of Pathology, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, 83301, Taiwan., Li HY; Institute of Precision Medicine, College of Medicine, National Sun Yat-sen University, Kaohsiung, 80424, Taiwan., Yang YC; Department of Biological Sciences, National Sun Yat-sen University, Kaohsiung, 80424, Taiwan.; Division of Neurosurgery, Division of Neurosurgery, Department of Surgery, Kaohsiung Veterans General Hospital, Kaohsiung, 813414, Taiwan., Lu H; Doctoral Program of Clinical and Experimental Medicine, College of Medicine, National Sun Yat-sen University, Kaohsiung, 80424, Taiwan., Pan CT; Institute of Precision Medicine, College of Medicine, National Sun Yat-sen University, Kaohsiung, 80424, Taiwan.; Department of Mechanical and Electro-Mechanical Engineering, National Sun Yat-sen University, Kaohsiung, 80424, Taiwan., Shiao MS; Research Laboratory Section, Offices of Health Science Research, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, 10400, Thailand., Lin YH; School of Medicine, College of Medicine, National Sun Yat-sen University, Kaohsiung, 80424, Taiwan. yhlin0619@vghks.gov.tw.; Department of Otolaryngology, Head and Neck Surgery, Kaohsiung Veterans General Hospital, Kaohsiung, 83301, Taiwan. yhlin0619@vghks.gov.tw.; School of Medicine, College of Medicine, National Yang Ming Chiao Tung University, Taipei, 112304, Taiwan. yhlin0619@vghks.gov.tw.; School of Medicine, Chung Shan Medical University, Taichung, 40201, Taiwan. yhlin0619@vghks.gov.tw., Shiue YL; Institute of Biomedical Sciences, College of Medicine, National Sun Yat-sen University, Kaohsiung, 80424, Taiwan. shirley@imst.nsysu.edu.tw.; Institute of Precision Medicine, College of Medicine, National Sun Yat-sen University, Kaohsiung, 80424, Taiwan. shirley@imst.nsysu.edu.tw.; Department of Biological Sciences, National Sun Yat-sen University, Kaohsiung, 80424, Taiwan. shirley@imst.nsysu.edu.tw. |
| Source: | Cellular and molecular life sciences : CMLS [Cell Mol Life Sci] 2026 Feb 21; Vol. 83 (1). Date of Electronic Publication: 2026 Feb 21. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Springer Country of Publication: Switzerland NLM ID: 9705402 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-9071 (Electronic) Linking ISSN: 1420682X NLM ISO Abbreviation: Cell Mol Life Sci Subsets: MEDLINE; In Process |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1420-9071 |
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| DOI: | 10.1007/s00018-025-06027-7 |
