ROS disrupt COP9 signalosome-mediated ABCA1 protection and trigger its ubiquitination and degradation by cullin3 inhibiting cholesterol efflux and promoting foam cell formation in response to GPCR agonists.
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| Title: | ROS disrupt COP9 signalosome-mediated ABCA1 protection and trigger its ubiquitination and degradation by cullin3 inhibiting cholesterol efflux and promoting foam cell formation in response to GPCR agonists. |
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| Authors: | Govatati S; Department of Physiology, University of Tennessee Health Science Center, Memphis, TN, 38163, USA., Yadavalli CS; Department of Physiology, University of Tennessee Health Science Center, Memphis, TN, 38163, USA., Traylor JG Jr; Department of Pathology, Louisiana State University Health Science Center, Shreveport, LA, 71103, USA., Orr AW; Department of Pathology, Louisiana State University Health Science Center, Shreveport, LA, 71103, USA., Rao GN; Department of Physiology, University of Tennessee Health Science Center, Memphis, TN, 38163, USA. Electronic address: rgadipar@uthsc.edu. |
| Source: | Redox biology [Redox Biol] 2026 Apr; Vol. 91, pp. 104095. Date of Electronic Publication: 2026 Feb 18. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Elsevier, B.V Country of Publication: Netherlands NLM ID: 101605639 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2213-2317 (Electronic) Linking ISSN: 22132317 NLM ISO Abbreviation: Redox Biol Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| ISSN: | 2213-2317 |
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| DOI: | 10.1016/j.redox.2026.104095 |
