MIF-CD74 axis facilitates MDSC infiltration in the tumor microenvironment of pancreatic ductal adenocarcinoma.

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Bibliographic Details
Title: MIF-CD74 axis facilitates MDSC infiltration in the tumor microenvironment of pancreatic ductal adenocarcinoma.
Authors: Fukuda H; Department of Immune Medicine, National Cancer Center Research Institute, Chuo-ku, Tokyo, Japan; Department of Urology, Tokyo Women's Medical University, Tokyo, Japan., Arai K; Department of Immune Medicine, National Cancer Center Research Institute, Chuo-ku, Tokyo, Japan., Hashimoto E; Department of Immune Medicine, National Cancer Center Research Institute, Chuo-ku, Tokyo, Japan; Chugai Life Science Park Yokohama, Chugai Pharmaceutical Co., Ltd., Yokohama, Kanagawa, Japan., Sekine K; Laboratory of Cancer Cell Systems, National Cancer Center Research Institute, Chuo-ku, Tokyo, Japan., Arai Y; Division of Cancer Genomics, National Cancer Center Research Institute, Chuo-ku, Tokyo, Japan., Hiraoka N; Division of Molecular Pathology, National Cancer Center Research Institute, Chuo-ku, Tokyo, Japan., Hirata A; Department of Immune Medicine, National Cancer Center Research Institute, Chuo-ku, Tokyo, Japan., Yamashita M; Department of Immune Medicine, National Cancer Center Research Institute, Chuo-ku, Tokyo, Japan; Department of Advanced Medical Development, The Japanese Foundation for Cancer Research, Koto-ku, Tokyo, Japan., Narumi K; Department of Immune Medicine, National Cancer Center Research Institute, Chuo-ku, Tokyo, Japan., Kikuchi A; Department of Immune Medicine, National Cancer Center Research Institute, Chuo-ku, Tokyo, Japan., Sawai E; Department of Immune Medicine, National Cancer Center Research Institute, Chuo-ku, Tokyo, Japan., Sawada Y; Department of Immune Medicine, National Cancer Center Research Institute, Chuo-ku, Tokyo, Japan., Sunami A; Department of Immune Medicine, National Cancer Center Research Institute, Chuo-ku, Tokyo, Japan., Mizoguchi Y; Department of Immune Medicine, National Cancer Center Research Institute, Chuo-ku, Tokyo, Japan., Sadahiro R; Department of Immune Medicine, National Cancer Center Research Institute, Chuo-ku, Tokyo, Japan., Aikawa Y; Department of Immune Medicine, National Cancer Center Research Institute, Chuo-ku, Tokyo, Japan., Henmi Y; Department of Immune Medicine, National Cancer Center Research Institute, Chuo-ku, Tokyo, Japan., Okumura G; Division of Cancer Immunology, National Cancer Center Research Institute, Chuo-ku, Tokyo, Japan; Department of Immunogenomic Medicine, National Cancer Center Research Institute, Chuo-ku, Tokyo, Japan., Sugiyama E; Department of Immunogenomic Medicine, National Cancer Center Research Institute, Chuo-ku, Tokyo, Japan., Takahashi M; Department of Pharmacology and Therapeutics, National Cancer Center Research Institute, Chuo-ku, Tokyo, Japan., Shibata T; Division of Cancer Genomics, National Cancer Center Research Institute, Chuo-ku, Tokyo, Japan., Nishito Y; Chugai Life Science Park Yokohama, Chugai Pharmaceutical Co., Ltd., Yokohama, Kanagawa, Japan., Mizuno H; Chugai Life Science Park Yokohama, Chugai Pharmaceutical Co., Ltd., Yokohama, Kanagawa, Japan., Nara S; Department of Hepatobiliary and Pancreatic Surgery, National Cancer Center Hospital, Chuo-ku, Tokyo, Japan., Esaki M; Department of Hepatobiliary and Pancreatic Surgery, National Cancer Center Hospital, Chuo-ku, Tokyo, Japan., Koyama S; Department of Immunogenomic Medicine, National Cancer Center Research Institute, Chuo-ku, Tokyo, Japan., Kitano S; Department of Advanced Medical Development, The Japanese Foundation for Cancer Research, Koto-ku, Tokyo, Japan., Yoshida T; Department of Genetic Medicine and Services, National Cancer Center Hospital, Chuo-ku, Tokyo, Japan., Ochiai A; Research Institute for Biomedical Sciences, Tokyo University of Science, Noda, Chiba, Japan., Tsunoda H; Chugai Life Science Park Yokohama, Chugai Pharmaceutical Co., Ltd., Yokohama, Kanagawa, Japan., Aoki K; Department of Immune Medicine, National Cancer Center Research Institute, Chuo-ku, Tokyo, Japan. Electronic address: kaoki@ncc.go.jp.
Source: Cancer letters [Cancer Lett] 2026 May 01; Vol. 645, pp. 218348. Date of Electronic Publication: 2026 Feb 20.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Science Ireland Country of Publication: Ireland NLM ID: 7600053 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-7980 (Electronic) Linking ISSN: 03043835 NLM ISO Abbreviation: Cancer Lett Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1872-7980
DOI:10.1016/j.canlet.2026.218348