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MIF-CD74 axis facilitates MDSC infiltration in the tumor microenvironment of pancreatic ductal adenocarcinoma.

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Title: MIF-CD74 axis facilitates MDSC infiltration in the tumor microenvironment of pancreatic ductal adenocarcinoma.
Authors: Fukuda H; Department of Immune Medicine, National Cancer Center Research Institute, Chuo-ku, Tokyo, Japan; Department of Urology, Tokyo Women's Medical University, Tokyo, Japan., Arai K; Department of Immune Medicine, National Cancer Center Research Institute, Chuo-ku, Tokyo, Japan., Hashimoto E; Department of Immune Medicine, National Cancer Center Research Institute, Chuo-ku, Tokyo, Japan; Chugai Life Science Park Yokohama, Chugai Pharmaceutical Co., Ltd., Yokohama, Kanagawa, Japan., Sekine K; Laboratory of Cancer Cell Systems, National Cancer Center Research Institute, Chuo-ku, Tokyo, Japan., Arai Y; Division of Cancer Genomics, National Cancer Center Research Institute, Chuo-ku, Tokyo, Japan., Hiraoka N; Division of Molecular Pathology, National Cancer Center Research Institute, Chuo-ku, Tokyo, Japan., Hirata A; Department of Immune Medicine, National Cancer Center Research Institute, Chuo-ku, Tokyo, Japan., Yamashita M; Department of Immune Medicine, National Cancer Center Research Institute, Chuo-ku, Tokyo, Japan; Department of Advanced Medical Development, The Japanese Foundation for Cancer Research, Koto-ku, Tokyo, Japan., Narumi K; Department of Immune Medicine, National Cancer Center Research Institute, Chuo-ku, Tokyo, Japan., Kikuchi A; Department of Immune Medicine, National Cancer Center Research Institute, Chuo-ku, Tokyo, Japan., Sawai E; Department of Immune Medicine, National Cancer Center Research Institute, Chuo-ku, Tokyo, Japan., Sawada Y; Department of Immune Medicine, National Cancer Center Research Institute, Chuo-ku, Tokyo, Japan., Sunami A; Department of Immune Medicine, National Cancer Center Research Institute, Chuo-ku, Tokyo, Japan., Mizoguchi Y; Department of Immune Medicine, National Cancer Center Research Institute, Chuo-ku, Tokyo, Japan., Sadahiro R; Department of Immune Medicine, National Cancer Center Research Institute, Chuo-ku, Tokyo, Japan., Aikawa Y; Department of Immune Medicine, National Cancer Center Research Institute, Chuo-ku, Tokyo, Japan., Henmi Y; Department of Immune Medicine, National Cancer Center Research Institute, Chuo-ku, Tokyo, Japan., Okumura G; Division of Cancer Immunology, National Cancer Center Research Institute, Chuo-ku, Tokyo, Japan; Department of Immunogenomic Medicine, National Cancer Center Research Institute, Chuo-ku, Tokyo, Japan., Sugiyama E; Department of Immunogenomic Medicine, National Cancer Center Research Institute, Chuo-ku, Tokyo, Japan., Takahashi M; Department of Pharmacology and Therapeutics, National Cancer Center Research Institute, Chuo-ku, Tokyo, Japan., Shibata T; Division of Cancer Genomics, National Cancer Center Research Institute, Chuo-ku, Tokyo, Japan., Nishito Y; Chugai Life Science Park Yokohama, Chugai Pharmaceutical Co., Ltd., Yokohama, Kanagawa, Japan., Mizuno H; Chugai Life Science Park Yokohama, Chugai Pharmaceutical Co., Ltd., Yokohama, Kanagawa, Japan., Nara S; Department of Hepatobiliary and Pancreatic Surgery, National Cancer Center Hospital, Chuo-ku, Tokyo, Japan., Esaki M; Department of Hepatobiliary and Pancreatic Surgery, National Cancer Center Hospital, Chuo-ku, Tokyo, Japan., Koyama S; Department of Immunogenomic Medicine, National Cancer Center Research Institute, Chuo-ku, Tokyo, Japan., Kitano S; Department of Advanced Medical Development, The Japanese Foundation for Cancer Research, Koto-ku, Tokyo, Japan., Yoshida T; Department of Genetic Medicine and Services, National Cancer Center Hospital, Chuo-ku, Tokyo, Japan., Ochiai A; Research Institute for Biomedical Sciences, Tokyo University of Science, Noda, Chiba, Japan., Tsunoda H; Chugai Life Science Park Yokohama, Chugai Pharmaceutical Co., Ltd., Yokohama, Kanagawa, Japan., Aoki K; Department of Immune Medicine, National Cancer Center Research Institute, Chuo-ku, Tokyo, Japan. Electronic address: kaoki@ncc.go.jp.
Source: Cancer letters [Cancer Lett] 2026 May 01; Vol. 645, pp. 218348. Date of Electronic Publication: 2026 Feb 20.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Science Ireland Country of Publication: Ireland NLM ID: 7600053 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-7980 (Electronic) Linking ISSN: 03043835 NLM ISO Abbreviation: Cancer Lett Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: MIF-CD74 axis facilitates MDSC infiltration in the tumor microenvironment of pancreatic ductal adenocarcinoma.
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  Data: <searchLink fieldCode="AU" term="%22Fukuda+H%22">Fukuda H</searchLink>; Department of Immune Medicine, National Cancer Center Research Institute, Chuo-ku, Tokyo, Japan; Department of Urology, Tokyo Women's Medical University, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Arai+K%22">Arai K</searchLink>; Department of Immune Medicine, National Cancer Center Research Institute, Chuo-ku, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Hashimoto+E%22">Hashimoto E</searchLink>; Department of Immune Medicine, National Cancer Center Research Institute, Chuo-ku, Tokyo, Japan; Chugai Life Science Park Yokohama, Chugai Pharmaceutical Co., Ltd., Yokohama, Kanagawa, Japan.<br /><searchLink fieldCode="AU" term="%22Sekine+K%22">Sekine K</searchLink>; Laboratory of Cancer Cell Systems, National Cancer Center Research Institute, Chuo-ku, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Arai+Y%22">Arai Y</searchLink>; Division of Cancer Genomics, National Cancer Center Research Institute, Chuo-ku, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Hiraoka+N%22">Hiraoka N</searchLink>; Division of Molecular Pathology, National Cancer Center Research Institute, Chuo-ku, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Hirata+A%22">Hirata A</searchLink>; Department of Immune Medicine, National Cancer Center Research Institute, Chuo-ku, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Yamashita+M%22">Yamashita M</searchLink>; Department of Immune Medicine, National Cancer Center Research Institute, Chuo-ku, Tokyo, Japan; Department of Advanced Medical Development, The Japanese Foundation for Cancer Research, Koto-ku, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Narumi+K%22">Narumi K</searchLink>; Department of Immune Medicine, National Cancer Center Research Institute, Chuo-ku, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Kikuchi+A%22">Kikuchi A</searchLink>; Department of Immune Medicine, National Cancer Center Research Institute, Chuo-ku, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Sawai+E%22">Sawai E</searchLink>; Department of Immune Medicine, National Cancer Center Research Institute, Chuo-ku, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Sawada+Y%22">Sawada Y</searchLink>; Department of Immune Medicine, National Cancer Center Research Institute, Chuo-ku, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Sunami+A%22">Sunami A</searchLink>; Department of Immune Medicine, National Cancer Center Research Institute, Chuo-ku, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Mizoguchi+Y%22">Mizoguchi Y</searchLink>; Department of Immune Medicine, National Cancer Center Research Institute, Chuo-ku, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Sadahiro+R%22">Sadahiro R</searchLink>; Department of Immune Medicine, National Cancer Center Research Institute, Chuo-ku, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Aikawa+Y%22">Aikawa Y</searchLink>; Department of Immune Medicine, National Cancer Center Research Institute, Chuo-ku, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Henmi+Y%22">Henmi Y</searchLink>; Department of Immune Medicine, National Cancer Center Research Institute, Chuo-ku, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Okumura+G%22">Okumura G</searchLink>; Division of Cancer Immunology, National Cancer Center Research Institute, Chuo-ku, Tokyo, Japan; Department of Immunogenomic Medicine, National Cancer Center Research Institute, Chuo-ku, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Sugiyama+E%22">Sugiyama E</searchLink>; Department of Immunogenomic Medicine, National Cancer Center Research Institute, Chuo-ku, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Takahashi+M%22">Takahashi M</searchLink>; Department of Pharmacology and Therapeutics, National Cancer Center Research Institute, Chuo-ku, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Shibata+T%22">Shibata T</searchLink>; Division of Cancer Genomics, National Cancer Center Research Institute, Chuo-ku, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Nishito+Y%22">Nishito Y</searchLink>; Chugai Life Science Park Yokohama, Chugai Pharmaceutical Co., Ltd., Yokohama, Kanagawa, Japan.<br /><searchLink fieldCode="AU" term="%22Mizuno+H%22">Mizuno H</searchLink>; Chugai Life Science Park Yokohama, Chugai Pharmaceutical Co., Ltd., Yokohama, Kanagawa, Japan.<br /><searchLink fieldCode="AU" term="%22Nara+S%22">Nara S</searchLink>; Department of Hepatobiliary and Pancreatic Surgery, National Cancer Center Hospital, Chuo-ku, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Esaki+M%22">Esaki M</searchLink>; Department of Hepatobiliary and Pancreatic Surgery, National Cancer Center Hospital, Chuo-ku, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Koyama+S%22">Koyama S</searchLink>; Department of Immunogenomic Medicine, National Cancer Center Research Institute, Chuo-ku, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Kitano+S%22">Kitano S</searchLink>; Department of Advanced Medical Development, The Japanese Foundation for Cancer Research, Koto-ku, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Yoshida+T%22">Yoshida T</searchLink>; Department of Genetic Medicine and Services, National Cancer Center Hospital, Chuo-ku, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Ochiai+A%22">Ochiai A</searchLink>; Research Institute for Biomedical Sciences, Tokyo University of Science, Noda, Chiba, Japan.<br /><searchLink fieldCode="AU" term="%22Tsunoda+H%22">Tsunoda H</searchLink>; Chugai Life Science Park Yokohama, Chugai Pharmaceutical Co., Ltd., Yokohama, Kanagawa, Japan.<br /><searchLink fieldCode="AU" term="%22Aoki+K%22">Aoki K</searchLink>; Department of Immune Medicine, National Cancer Center Research Institute, Chuo-ku, Tokyo, Japan. Electronic address: kaoki@ncc.go.jp.
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  Data: <searchLink fieldCode="JN" term="%227600053%22">Cancer letters</searchLink> [Cancer Lett] 2026 May 01; Vol. 645, pp. 218348. <i>Date of Electronic Publication: </i>2026 Feb 20.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier+Science+Ireland%22">Elsevier Science Ireland </searchLink><i>Country of Publication: </i>Ireland <i>NLM ID: </i>7600053 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1872-7980 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2203043835%22">03043835 </searchLink><i>NLM ISO Abbreviation: </i>Cancer Lett <i>Subsets: </i>MEDLINE
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