Modeling mitochondrial inheritance enables high-precision single-cell lineage tracing in humans.

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Title: Modeling mitochondrial inheritance enables high-precision single-cell lineage tracing in humans.
Authors: Gao T; Division of Hematology/Oncology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.; Howard Hughes Medical Institute, Boston, MA, USA.; Broad Institute of MIT and Harvard, Boston, MA, USA., Weng C; Division of Hematology/Oncology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.; Howard Hughes Medical Institute, Boston, MA, USA.; Broad Institute of MIT and Harvard, Boston, MA, USA.; Whitehead Institute for Biomedical Research, Cambridge, MA, USA.; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA., Johnson I; Division of Hematology/Oncology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.; Howard Hughes Medical Institute, Boston, MA, USA.; Broad Institute of MIT and Harvard, Boston, MA, USA., Poeschla M; Division of Hematology/Oncology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.; Howard Hughes Medical Institute, Boston, MA, USA.; Broad Institute of MIT and Harvard, Boston, MA, USA., Gudera J; Division of Hematology/Oncology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.; Howard Hughes Medical Institute, Boston, MA, USA.; Broad Institute of MIT and Harvard, Boston, MA, USA., King E; Division of Hematology/Oncology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.; Howard Hughes Medical Institute, Boston, MA, USA.; Broad Institute of MIT and Harvard, Boston, MA, USA., Rouya C; Division of Hematology/Oncology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.; Howard Hughes Medical Institute, Boston, MA, USA.; Broad Institute of MIT and Harvard, Boston, MA, USA., Donovan A; Branch Biosciences, Cambridge, MA, USA., Bourke L; Branch Biosciences, Cambridge, MA, USA., Shao Y; Branch Biosciences, Cambridge, MA, USA., Marquez E; Branch Biosciences, Cambridge, MA, USA., Tyagi R; Branch Biosciences, Cambridge, MA, USA., Zon LI; Division of Hematology/Oncology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.; Howard Hughes Medical Institute, Boston, MA, USA.; Harvard Stem Cell Institute, Cambridge, MA, USA., Weissman JS; Howard Hughes Medical Institute, Boston, MA, USA.; Whitehead Institute for Biomedical Research, Cambridge, MA, USA.; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA., Sankaran VG; Division of Hematology/Oncology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.; Howard Hughes Medical Institute, Boston, MA, USA.; Broad Institute of MIT and Harvard, Boston, MA, USA.; Harvard Stem Cell Institute, Cambridge, MA, USA.
Source: BioRxiv : the preprint server for biology [bioRxiv] 2026 Feb 18. Date of Electronic Publication: 2026 Feb 18.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2692-8205
DOI:10.64898/2026.02.12.705660