Memory-like CD8+ T cells lacking PD-1 adapt to persistent stimulation by reducing TCR signal transduction rather than increasing exhaustion.
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| Title: | Memory-like CD8+ T cells lacking PD-1 adapt to persistent stimulation by reducing TCR signal transduction rather than increasing exhaustion. |
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| Authors: | Charmoy M; Department of Fundamental Oncology, University of Lausanne, Lausanne, Switzerland., Maier JM; Department of Fundamental Oncology, University of Lausanne, Lausanne, Switzerland., Wyss T; Translational Data Science Facility, AGORA Cancer Research Center, Swiss Institute of Bioinformatics., Lausanne, Switzerland., Chennupati V; Department of Fundamental Oncology, University of Lausanne, Lausanne, Switzerland., Sabatel C; Department of Fundamental Oncology, University of Lausanne, Lausanne, Switzerland., Bonneaux L; Department of Fundamental Oncology, University of Lausanne, Lausanne, Switzerland., Dumez A; Department of Fundamental Oncology, University of Lausanne, Lausanne, Switzerland., Veber R; Department of Fundamental Oncology, University of Lausanne, Lausanne, Switzerland., Guarda G; Institute for Research in Biomedicine, Università della Svizzera Italiana, Bellinzona, Switzerland., Held W; Department of Fundamental Oncology, University of Lausanne, Lausanne, Switzerland. |
| Source: | Frontiers in immunology [Front Immunol] 2026 Feb 05; Vol. 17, pp. 1743170. Date of Electronic Publication: 2026 Feb 05 (Print Publication: 2026). |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1664-3224 |
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| DOI: | 10.3389/fimmu.2026.1743170 |
