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Memory-like CD8+ T cells lacking PD-1 adapt to persistent stimulation by reducing TCR signal transduction rather than increasing exhaustion.

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Title: Memory-like CD8+ T cells lacking PD-1 adapt to persistent stimulation by reducing TCR signal transduction rather than increasing exhaustion.
Authors: Charmoy M; Department of Fundamental Oncology, University of Lausanne, Lausanne, Switzerland., Maier JM; Department of Fundamental Oncology, University of Lausanne, Lausanne, Switzerland., Wyss T; Translational Data Science Facility, AGORA Cancer Research Center, Swiss Institute of Bioinformatics., Lausanne, Switzerland., Chennupati V; Department of Fundamental Oncology, University of Lausanne, Lausanne, Switzerland., Sabatel C; Department of Fundamental Oncology, University of Lausanne, Lausanne, Switzerland., Bonneaux L; Department of Fundamental Oncology, University of Lausanne, Lausanne, Switzerland., Dumez A; Department of Fundamental Oncology, University of Lausanne, Lausanne, Switzerland., Veber R; Department of Fundamental Oncology, University of Lausanne, Lausanne, Switzerland., Guarda G; Institute for Research in Biomedicine, Università della Svizzera Italiana, Bellinzona, Switzerland., Held W; Department of Fundamental Oncology, University of Lausanne, Lausanne, Switzerland.
Source: Frontiers in immunology [Front Immunol] 2026 Feb 05; Vol. 17, pp. 1743170. Date of Electronic Publication: 2026 Feb 05 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Memory-like CD8<superscript>+</superscript> T cells lacking PD-1 adapt to persistent stimulation by reducing TCR signal transduction rather than increasing exhaustion.
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  Data: <searchLink fieldCode="AU" term="%22Charmoy+M%22">Charmoy M</searchLink>; Department of Fundamental Oncology, University of Lausanne, Lausanne, Switzerland.<br /><searchLink fieldCode="AU" term="%22Maier+JM%22">Maier JM</searchLink>; Department of Fundamental Oncology, University of Lausanne, Lausanne, Switzerland.<br /><searchLink fieldCode="AU" term="%22Wyss+T%22">Wyss T</searchLink>; Translational Data Science Facility, AGORA Cancer Research Center, Swiss Institute of Bioinformatics., Lausanne, Switzerland.<br /><searchLink fieldCode="AU" term="%22Chennupati+V%22">Chennupati V</searchLink>; Department of Fundamental Oncology, University of Lausanne, Lausanne, Switzerland.<br /><searchLink fieldCode="AU" term="%22Sabatel+C%22">Sabatel C</searchLink>; Department of Fundamental Oncology, University of Lausanne, Lausanne, Switzerland.<br /><searchLink fieldCode="AU" term="%22Bonneaux+L%22">Bonneaux L</searchLink>; Department of Fundamental Oncology, University of Lausanne, Lausanne, Switzerland.<br /><searchLink fieldCode="AU" term="%22Dumez+A%22">Dumez A</searchLink>; Department of Fundamental Oncology, University of Lausanne, Lausanne, Switzerland.<br /><searchLink fieldCode="AU" term="%22Veber+R%22">Veber R</searchLink>; Department of Fundamental Oncology, University of Lausanne, Lausanne, Switzerland.<br /><searchLink fieldCode="AU" term="%22Guarda+G%22">Guarda G</searchLink>; Institute for Research in Biomedicine, Università della Svizzera Italiana, Bellinzona, Switzerland.<br /><searchLink fieldCode="AU" term="%22Held+W%22">Held W</searchLink>; Department of Fundamental Oncology, University of Lausanne, Lausanne, Switzerland.
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  Data: <searchLink fieldCode="JN" term="%22101560960%22">Frontiers in immunology</searchLink> [Front Immunol] 2026 Feb 05; Vol. 17, pp. 1743170. <i>Date of Electronic Publication: </i>2026 Feb 05 (<i>Print Publication: </i>2026).
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Frontiers+Research+Foundation]%22">Frontiers Research Foundation] </searchLink><i>Country of Publication: </i>Switzerland <i>NLM ID: </i>101560960 <i>Publication Model: </i>eCollection <i>Cited Medium: </i>Internet <i>ISSN: </i>1664-3224 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2216643224%22">16643224 </searchLink><i>NLM ISO Abbreviation: </i>Front Immunol <i>Subsets: </i>MEDLINE
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        Value: 10.3389/fimmu.2026.1743170
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        Text: English
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              Text: 2026 Feb 05
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