Safety and clinical outcomes of a first-in-human trial of point-of-care manufactured trispecific CAR T cells targeting CD19, CD20, and CD22.

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Title: Safety and clinical outcomes of a first-in-human trial of point-of-care manufactured trispecific CAR T cells targeting CD19, CD20, and CD22.
Authors: Vasu S; The Ohio State University., Denlinger N; The Ohio State University., Song NJ; The Ohio State University., Elsberry D; The Ohio State University., Zhao Q; The Ohio State University., Yu L; The Ohio State University., Bezerra E; Cleveland Clinic., Szuminski N; The Ohio State University., Schneider D; Cartesian Therapeutics., Dash P; Lentigen Technology Inc., A Miltenyi Biotec Company., Wirthlin L; Lentigen Technology Inc., A Miltenyi Biotec Company., Epperla N; Huntsman Cancer Institute., Sawalha Y; The Ohio State University., Woyach J; The Ohio State University., Nishat S; The Ohio State University., Rogers K; The Ohio State University., Bhat S; The Ohio State University., Ghoneim H; The Ohio State University., Behbehani G; The Ohio State University., Voorhees T; The Ohio State University., Larkin K; The Ohio State University., Kittai A; Icahn School of Medicine at Mount Sinai., Churchill V; The Ohio State University., George E; Nationwide Children's Hospital., Lamb M; Nationwide Children's Hospital., Lee D; Center for Childhood Cancer and Blood Diseases, Abigail Wexner Research Institute at Nationwide Children's Hospital., Chan W; The Ohio State University., Krull A; The Ohio State University., Orentas R; Lentigen Technology Inc., A Miltenyi Biotec Company., O'Donnell L; The Ohio State University., Li Z; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute., Alinari L; The Ohio State University., de Lima M; The James Comprehensive Cancer Center, The Ohio State Univ.
Source: Research square [Res Sq] 2026 Feb 09. Date of Electronic Publication: 2026 Feb 09.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101768035 Publication Model: Electronic Cited Medium: Internet ISSN: 2693-5015 (Electronic) Linking ISSN: 26935015 NLM ISO Abbreviation: Res Sq Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2693-5015
DOI:10.21203/rs.3.rs-8605291/v1