Structural and dynamic insights into agonist recognition and function of the thromboxane A2 receptor.

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Title: Structural and dynamic insights into agonist recognition and function of the thromboxane A2 receptor.
Authors: Krawinski P; School of Medicine and School of Biochemistry and Immunology, Trinity College Dublin, Dublin, Ireland., Matzov D; Department of Chemical and Structural Biology, Weizmann Institute of Science, Rehovot, Israel., Ryder A; School of Medicine and School of Biochemistry and Immunology, Trinity College Dublin, Dublin, Ireland., Lal K; School of Pharmacy, Queen's University Belfast, Belfast, UK., Karlov DS; School of Pharmacy, Queen's University Belfast, Belfast, UK., Chalhoub G; Department of Pharmacology and Therapeutics, University of Liverpool, Institute of Systems, Molecular and Integrative Biology, Sherrington Building, Liverpool, UK.; Centre for Endocrinology, William Harvey Research Institute, Barts and the London School of Medicine, Queen Mary, University of London, London, UK., Mulvaney EP; ATXA Therapeutics Limited, UCD Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Belfield, Ireland., Kinsella BT; ATXA Therapeutics Limited, UCD Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Belfield, Ireland., McCormick PJ; Department of Pharmacology and Therapeutics, University of Liverpool, Institute of Systems, Molecular and Integrative Biology, Sherrington Building, Liverpool, UK.; Centre for Endocrinology, William Harvey Research Institute, Barts and the London School of Medicine, Queen Mary, University of London, London, UK., Caffrey M; School of Medicine and School of Biochemistry and Immunology, Trinity College Dublin, Dublin, Ireland. martin.caffrey@tcd.ie., Tikhonova IG; School of Pharmacy, Queen's University Belfast, Belfast, UK. i.tikhonova@qub.ac.uk., Shalev-Benami M; Department of Chemical and Structural Biology, Weizmann Institute of Science, Rehovot, Israel. moransb@weizmann.ac.il.
Source: Nature communications [Nat Commun] 2026 Feb 23; Vol. 17 (1). Date of Electronic Publication: 2026 Feb 23.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:2041-1723
DOI:10.1038/s41467-026-69844-9