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Sulfated glycosaminoglycans inhibit LCMV entry and modulate antiviral immunity and pathology.

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Title: Sulfated glycosaminoglycans inhibit LCMV entry and modulate antiviral immunity and pathology.
Authors: Gorzkiewicz M; Department of Molecular Medicine II, Medical Faculty and University Hospital, Heinrich Heine University Düsseldorf, Universitätsstr. 1, Düsseldorf, 40225, Germany.; Department of General Biophysics, Faculty of Biology and Environmental Protection, University of Lodz, 141/143 Pomorska St., Lodz, 90-236, Poland., Noseir S; Department of Molecular Medicine II, Medical Faculty and University Hospital, Heinrich Heine University Düsseldorf, Universitätsstr. 1, Düsseldorf, 40225, Germany., Vengurlekar M; Department of Molecular Medicine II, Medical Faculty and University Hospital, Heinrich Heine University Düsseldorf, Universitätsstr. 1, Düsseldorf, 40225, Germany., Ghosh M; Department of Molecular Medicine II, Medical Faculty and University Hospital, Heinrich Heine University Düsseldorf, Universitätsstr. 1, Düsseldorf, 40225, Germany., Katahira I; Department of Molecular Medicine II, Medical Faculty and University Hospital, Heinrich Heine University Düsseldorf, Universitätsstr. 1, Düsseldorf, 40225, Germany., Abromavičiūtė D; Department of Molecular Medicine II, Medical Faculty and University Hospital, Heinrich Heine University Düsseldorf, Universitätsstr. 1, Düsseldorf, 40225, Germany., Gerling-Driessen U; Institute for Macromolecular Chemistry, University of Freiburg, Stefan-Meier-Str. 31, Freiburg, 79104, Germany., Bonda L; Department of Organic and Macromolecular Chemistry, Heinrich Heine University Düsseldorf, Universitätsstr. 1, Düsseldorf, 40225, Germany., Rähse N; Institute for Pharmaceutical and Medicinal Chemistry, Heinrich Heine University Düsseldorf, Universitätsstr. 1, Düsseldorf, 40225, Germany., Lapsien M; Institute for Pharmaceutical and Medicinal Chemistry, Heinrich Heine University Düsseldorf, Universitätsstr. 1, Düsseldorf, 40225, Germany., Bockholt S; Bernhard Nocht Institute for Tropical Medicine, Bernhard-Nocht-Str. 74, Hamburg, 20359, Germany., Bergmann AK; Core Facility Electron Microscopy, Medical Faculty and University Hospital, Heinrich Heine University, Universitätsstr. 1, Düsseldorf, 40225, Germany., Kostadinovska K; Department of Molecular Medicine II, Medical Faculty and University Hospital, Heinrich Heine University Düsseldorf, Universitätsstr. 1, Düsseldorf, 40225, Germany., Fraii H; Department of Molecular Medicine II, Medical Faculty and University Hospital, Heinrich Heine University Düsseldorf, Universitätsstr. 1, Düsseldorf, 40225, Germany., Lang KS; Institute of Immunology, University Hospital Essen, Hufelandstr. 55, Essen, 45122, Germany., Oestereich L; Bernhard Nocht Institute for Tropical Medicine, Bernhard-Nocht-Str. 74, Hamburg, 20359, Germany.; German Center for Infection Research, Partner Site Hamburg-Lübeck-Borstel-Riems, Hamburg, Germany., Gohlke H; Institute for Pharmaceutical and Medicinal Chemistry, Heinrich Heine University Düsseldorf, Universitätsstr. 1, Düsseldorf, 40225, Germany.; Institute of Bio- and Geosciences (IBG-4: Bioinformatics), Forschungszentrum Jülich GmbH, Wilhelm-Johnen-Straße, Jülich, 52428, Germany., Hartmann L; Institute for Macromolecular Chemistry, University of Freiburg, Stefan-Meier-Str. 31, Freiburg, 79104, Germany., Lang PA; Department of Molecular Medicine II, Medical Faculty and University Hospital, Heinrich Heine University Düsseldorf, Universitätsstr. 1, Düsseldorf, 40225, Germany. langp@uni-duesseldorf.de.
Source: EMBO molecular medicine [EMBO Mol Med] 2026 Apr; Vol. 18 (4), pp. 1235-1264. Date of Electronic Publication: 2026 Feb 23.
Publication Type: Journal Article
Journal Info: Publisher: EMBO Press Country of Publication: Germany NLM ID: 101487380 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1757-4684 (Electronic) Linking ISSN: 17574676 NLM ISO Abbreviation: EMBO Mol Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1757-4684
DOI:10.1038/s44321-026-00387-8