Male obesity causes adipose mitochondrial dysfunction in F1 mouse progeny via a let-7-DICER axis.
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| Title: | Male obesity causes adipose mitochondrial dysfunction in F |
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| Authors: | Huang C; Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark.; Laboratory of Animal Physiology, Department of Animal Science and Technology, National Taiwan University, Taipei, Taiwan., Park JH; Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark., Altıntaş A; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Stanic N; Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark., Kyle de Leon K; Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark., Isacson S; Division of Cell and Neurobiology, Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden., Kalogeropoulos P; Science for Life Laboratory, Department of Molecular Biosciences, The Wenner-Gren-Institute, Stockholm University, Stockholm, Sweden., Topel H; Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark.; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Madsen T; Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark., Zanner S; Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark., Ruppert PM; Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark., Valdebenito R; Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark., Havelund J; Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark., Larsen BDM; Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark., Chien YT; Laboratory of Animal Physiology, Department of Animal Science and Technology, National Taiwan University, Taipei, Taiwan., Huang WC; Laboratory of Animal Physiology, Department of Animal Science and Technology, National Taiwan University, Taipei, Taiwan., Budi YP; Graduate Institute of Molecular and Comparative Pathobiology, School of Veterinary Medicine, National Taiwan University, Taipei, Taiwan., Jiang YF; Graduate Institute of Molecular and Comparative Pathobiology, School of Veterinary Medicine, National Taiwan University, Taipei, Taiwan., Rocha AL; Clayton Foundation Laboratories for Peptide Biology, Salk Institute for Biological Studies, La Jolla, CA, USA., Lima-Junior NC; Department of Biochemistry and Tissue Biology, Institute of Biology, Universidade Estadual de Campinas, Campinas, SP, Brazil., Szczepanowska K; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases & Center for Molecular Medicine, University of Cologne, Cologne, Germany.; IMol Polish Academy of Sciences, 02-247, Warsaw, Poland., Lackmann JW; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases & Center for Molecular Medicine, University of Cologne, Cologne, Germany., Trifunovic A; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases & Center for Molecular Medicine, University of Cologne, Cologne, Germany., Hejbøl EK; Winsløw Unit for Anatomy, Histology and Plastination, Department of Molecular Medicine, University of Southern Denmark, Odense, Denmark., Detlefsen S; Department of Pathology, Odense University Hospital, Odense, Denmark.; Department of Clinical Research, Faculty of Health Science, University of Southern Denmark, Odense, Denmark., Jepsen IE; The Fertility Clinic, Department of Obstetrics and Gynaecology, Zealand University Hospital, Koege, Denmark., Kolstrup SH; Biomedical Laboratory, Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark., Laguna-Barraza R; Core Facility for Transgenic Mice, Department of Experimental Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Martin-Gonzalez J; Core Facility for Transgenic Mice, Department of Experimental Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Khodosevich K; Biotech Research & Innovation Centre, University of Copenhagen, Copenhagen, Denmark., Færgeman NJ; Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark., Mori MA; Department of Biochemistry and Tissue Biology, Institute of Biology, Universidade Estadual de Campinas, Campinas, São Paulo, Brazil.; Program in Genetics and Molecular Biology, Institute of Biology, Universidade Estadual de Campinas, Campinas, São Paulo, Brazil.; Obesity and Comorbidities Research Center (OCRC), Universidade Estadual de Campinas, Campinas, São Paulo, Brazil.; Experimental Medicine Research Cluster, Universidade Estadual de Campinas, Campinas, São Paulo, Brazil., Friedländer MR; Science for Life Laboratory, Department of Molecular Biosciences, The Wenner-Gren-Institute, Stockholm University, Stockholm, Sweden., Öst A; Division of Cell and Neurobiology, Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden., Barrès R; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Institut de Pharmacologie Moléculaire et Cellulaire, Université Côte d'Azur & Centre National pour la Recherche Scientifique, Valbonne, France., Kornfeld JW; Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark. janwilhelmkornfeld@bmb.sdu.dk.; Novo Nordisk Foundation Center for Adipocyte Signalling, University of Southern Denmark, Odense, Denmark. janwilhelmkornfeld@bmb.sdu.dk. |
| Source: | Nature communications [Nat Commun] 2026 Feb 24; Vol. 17 (1). Date of Electronic Publication: 2026 Feb 24. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2041-1723 |
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| DOI: | 10.1038/s41467-026-69686-5 |
