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Male obesity causes adipose mitochondrial dysfunction in F1 mouse progeny via a let-7-DICER axis.

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Title: Male obesity causes adipose mitochondrial dysfunction in F1 mouse progeny via a let-7-DICER axis.
Authors: Huang C; Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark.; Laboratory of Animal Physiology, Department of Animal Science and Technology, National Taiwan University, Taipei, Taiwan., Park JH; Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark., Altıntaş A; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Stanic N; Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark., Kyle de Leon K; Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark., Isacson S; Division of Cell and Neurobiology, Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden., Kalogeropoulos P; Science for Life Laboratory, Department of Molecular Biosciences, The Wenner-Gren-Institute, Stockholm University, Stockholm, Sweden., Topel H; Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark.; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Madsen T; Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark., Zanner S; Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark., Ruppert PM; Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark., Valdebenito R; Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark., Havelund J; Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark., Larsen BDM; Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark., Chien YT; Laboratory of Animal Physiology, Department of Animal Science and Technology, National Taiwan University, Taipei, Taiwan., Huang WC; Laboratory of Animal Physiology, Department of Animal Science and Technology, National Taiwan University, Taipei, Taiwan., Budi YP; Graduate Institute of Molecular and Comparative Pathobiology, School of Veterinary Medicine, National Taiwan University, Taipei, Taiwan., Jiang YF; Graduate Institute of Molecular and Comparative Pathobiology, School of Veterinary Medicine, National Taiwan University, Taipei, Taiwan., Rocha AL; Clayton Foundation Laboratories for Peptide Biology, Salk Institute for Biological Studies, La Jolla, CA, USA., Lima-Junior NC; Department of Biochemistry and Tissue Biology, Institute of Biology, Universidade Estadual de Campinas, Campinas, SP, Brazil., Szczepanowska K; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases & Center for Molecular Medicine, University of Cologne, Cologne, Germany.; IMol Polish Academy of Sciences, 02-247, Warsaw, Poland., Lackmann JW; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases & Center for Molecular Medicine, University of Cologne, Cologne, Germany., Trifunovic A; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases & Center for Molecular Medicine, University of Cologne, Cologne, Germany., Hejbøl EK; Winsløw Unit for Anatomy, Histology and Plastination, Department of Molecular Medicine, University of Southern Denmark, Odense, Denmark., Detlefsen S; Department of Pathology, Odense University Hospital, Odense, Denmark.; Department of Clinical Research, Faculty of Health Science, University of Southern Denmark, Odense, Denmark., Jepsen IE; The Fertility Clinic, Department of Obstetrics and Gynaecology, Zealand University Hospital, Koege, Denmark., Kolstrup SH; Biomedical Laboratory, Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark., Laguna-Barraza R; Core Facility for Transgenic Mice, Department of Experimental Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Martin-Gonzalez J; Core Facility for Transgenic Mice, Department of Experimental Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Khodosevich K; Biotech Research & Innovation Centre, University of Copenhagen, Copenhagen, Denmark., Færgeman NJ; Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark., Mori MA; Department of Biochemistry and Tissue Biology, Institute of Biology, Universidade Estadual de Campinas, Campinas, São Paulo, Brazil.; Program in Genetics and Molecular Biology, Institute of Biology, Universidade Estadual de Campinas, Campinas, São Paulo, Brazil.; Obesity and Comorbidities Research Center (OCRC), Universidade Estadual de Campinas, Campinas, São Paulo, Brazil.; Experimental Medicine Research Cluster, Universidade Estadual de Campinas, Campinas, São Paulo, Brazil., Friedländer MR; Science for Life Laboratory, Department of Molecular Biosciences, The Wenner-Gren-Institute, Stockholm University, Stockholm, Sweden., Öst A; Division of Cell and Neurobiology, Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden., Barrès R; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Institut de Pharmacologie Moléculaire et Cellulaire, Université Côte d'Azur & Centre National pour la Recherche Scientifique, Valbonne, France., Kornfeld JW; Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark. janwilhelmkornfeld@bmb.sdu.dk.; Novo Nordisk Foundation Center for Adipocyte Signalling, University of Southern Denmark, Odense, Denmark. janwilhelmkornfeld@bmb.sdu.dk.
Source: Nature communications [Nat Commun] 2026 Feb 24; Vol. 17 (1). Date of Electronic Publication: 2026 Feb 24.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Male obesity causes adipose mitochondrial dysfunction in F<subscript>1</subscript> mouse progeny via a let-7-DICER axis.
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  Data: <searchLink fieldCode="AU" term="%22Huang+C%22">Huang C</searchLink>; Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark.; Laboratory of Animal Physiology, Department of Animal Science and Technology, National Taiwan University, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Park+JH%22">Park JH</searchLink>; Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark.<br /><searchLink fieldCode="AU" term="%22Altıntaş+A%22">Altıntaş A</searchLink>; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Stanic+N%22">Stanic N</searchLink>; Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark.<br /><searchLink fieldCode="AU" term="%22Kyle+de+Leon+K%22">Kyle de Leon K</searchLink>; Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark.<br /><searchLink fieldCode="AU" term="%22Isacson+S%22">Isacson S</searchLink>; Division of Cell and Neurobiology, Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden.<br /><searchLink fieldCode="AU" term="%22Kalogeropoulos+P%22">Kalogeropoulos P</searchLink>; Science for Life Laboratory, Department of Molecular Biosciences, The Wenner-Gren-Institute, Stockholm University, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Topel+H%22">Topel H</searchLink>; Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark.; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Madsen+T%22">Madsen T</searchLink>; Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark.<br /><searchLink fieldCode="AU" term="%22Zanner+S%22">Zanner S</searchLink>; Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark.<br /><searchLink fieldCode="AU" term="%22Ruppert+PM%22">Ruppert PM</searchLink>; Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark.<br /><searchLink fieldCode="AU" term="%22Valdebenito+R%22">Valdebenito R</searchLink>; Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark.<br /><searchLink fieldCode="AU" term="%22Havelund+J%22">Havelund J</searchLink>; Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark.<br /><searchLink fieldCode="AU" term="%22Larsen+BDM%22">Larsen BDM</searchLink>; Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark.<br /><searchLink fieldCode="AU" term="%22Chien+YT%22">Chien YT</searchLink>; Laboratory of Animal Physiology, Department of Animal Science and Technology, National Taiwan University, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Huang+WC%22">Huang WC</searchLink>; Laboratory of Animal Physiology, Department of Animal Science and Technology, National Taiwan University, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Budi+YP%22">Budi YP</searchLink>; Graduate Institute of Molecular and Comparative Pathobiology, School of Veterinary Medicine, National Taiwan University, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Jiang+YF%22">Jiang YF</searchLink>; Graduate Institute of Molecular and Comparative Pathobiology, School of Veterinary Medicine, National Taiwan University, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Rocha+AL%22">Rocha AL</searchLink>; Clayton Foundation Laboratories for Peptide Biology, Salk Institute for Biological Studies, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Lima-Junior+NC%22">Lima-Junior NC</searchLink>; Department of Biochemistry and Tissue Biology, Institute of Biology, Universidade Estadual de Campinas, Campinas, SP, Brazil.<br /><searchLink fieldCode="AU" term="%22Szczepanowska+K%22">Szczepanowska K</searchLink>; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases & Center for Molecular Medicine, University of Cologne, Cologne, Germany.; IMol Polish Academy of Sciences, 02-247, Warsaw, Poland.<br /><searchLink fieldCode="AU" term="%22Lackmann+JW%22">Lackmann JW</searchLink>; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases & Center for Molecular Medicine, University of Cologne, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Trifunovic+A%22">Trifunovic A</searchLink>; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases & Center for Molecular Medicine, University of Cologne, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Hejbøl+EK%22">Hejbøl EK</searchLink>; Winsløw Unit for Anatomy, Histology and Plastination, Department of Molecular Medicine, University of Southern Denmark, Odense, Denmark.<br /><searchLink fieldCode="AU" term="%22Detlefsen+S%22">Detlefsen S</searchLink>; Department of Pathology, Odense University Hospital, Odense, Denmark.; Department of Clinical Research, Faculty of Health Science, University of Southern Denmark, Odense, Denmark.<br /><searchLink fieldCode="AU" term="%22Jepsen+IE%22">Jepsen IE</searchLink>; The Fertility Clinic, Department of Obstetrics and Gynaecology, Zealand University Hospital, Koege, Denmark.<br /><searchLink fieldCode="AU" term="%22Kolstrup+SH%22">Kolstrup SH</searchLink>; Biomedical Laboratory, Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark.<br /><searchLink fieldCode="AU" term="%22Laguna-Barraza+R%22">Laguna-Barraza R</searchLink>; Core Facility for Transgenic Mice, Department of Experimental Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Martin-Gonzalez+J%22">Martin-Gonzalez J</searchLink>; Core Facility for Transgenic Mice, Department of Experimental Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Khodosevich+K%22">Khodosevich K</searchLink>; Biotech Research & Innovation Centre, University of Copenhagen, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Færgeman+NJ%22">Færgeman NJ</searchLink>; Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark.<br /><searchLink fieldCode="AU" term="%22Mori+MA%22">Mori MA</searchLink>; Department of Biochemistry and Tissue Biology, Institute of Biology, Universidade Estadual de Campinas, Campinas, São Paulo, Brazil.; Program in Genetics and Molecular Biology, Institute of Biology, Universidade Estadual de Campinas, Campinas, São Paulo, Brazil.; Obesity and Comorbidities Research Center (OCRC), Universidade Estadual de Campinas, Campinas, São Paulo, Brazil.; Experimental Medicine Research Cluster, Universidade Estadual de Campinas, Campinas, São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Friedländer+MR%22">Friedländer MR</searchLink>; Science for Life Laboratory, Department of Molecular Biosciences, The Wenner-Gren-Institute, Stockholm University, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Öst+A%22">Öst A</searchLink>; Division of Cell and Neurobiology, Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden.<br /><searchLink fieldCode="AU" term="%22Barrès+R%22">Barrès R</searchLink>; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Institut de Pharmacologie Moléculaire et Cellulaire, Université Côte d'Azur & Centre National pour la Recherche Scientifique, Valbonne, France.<br /><searchLink fieldCode="AU" term="%22Kornfeld+JW%22">Kornfeld JW</searchLink>; Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark. janwilhelmkornfeld@bmb.sdu.dk.; Novo Nordisk Foundation Center for Adipocyte Signalling, University of Southern Denmark, Odense, Denmark. janwilhelmkornfeld@bmb.sdu.dk.
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