Temporal and cell-type specific SPAK-NKCC1 disruption following severe TBI in the developing gyrencephalic brain.

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Title: Temporal and cell-type specific SPAK-NKCC1 disruption following severe TBI in the developing gyrencephalic brain.
Authors: Hochstetler A; MGH Brain Trauma Lab, Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02115, USA.; Department of Pathology, Boston Children's Hospital, Harvard Medical School, Boston, MA, 02115, USA., Courtney Y; Department of Pathology, Boston Children's Hospital, Harvard Medical School, Boston, MA, 02115, USA.; Graduate Program in Neuroscience, Harvard Medical School, Boston, MA, 02115, USA., Oloko P; MGH Brain Trauma Lab, Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02115, USA., Baskin B; MGH Brain Trauma Lab, Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02115, USA., Ding-Su A; MGH Brain Trauma Lab, Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02115, USA., Stinson T; MGH Brain Trauma Lab, Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02115, USA., Alber E; Neurovascular Research Unit, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02115, USA., Chung DY; Neurovascular Research Unit, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02115, USA., McGuone D; Department of Pathology, Yale University School of Medicine, New Haven, CT, 06510, USA., Haynes R; Department of Pathology, Boston Children's Hospital, Harvard Medical School, Boston, MA, 02115, USA., Lehtinen MK; Department of Pathology, Boston Children's Hospital, Harvard Medical School, Boston, MA, 02115, USA.; Graduate Program in Neuroscience, Harvard Medical School, Boston, MA, 02115, USA., Costine-Bartell B; MGH Brain Trauma Lab, Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02115, USA. bcostinebartell@mgh.harvard.edu.
Source: Acta neuropathologica communications [Acta Neuropathol Commun] 2026 Feb 24; Vol. 14 (1). Date of Electronic Publication: 2026 Feb 24.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101610673 Publication Model: Electronic Cited Medium: Internet ISSN: 2051-5960 (Electronic) Linking ISSN: 20515960 NLM ISO Abbreviation: Acta Neuropathol Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2051-5960
DOI:10.1186/s40478-026-02257-3