FAK inhibition in ovarian cancer releases omega-3 fatty acids to program CXCL13-producing anti-tumor resident peritoneal macrophages.

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Title: FAK inhibition in ovarian cancer releases omega-3 fatty acids to program CXCL13-producing anti-tumor resident peritoneal macrophages.
Authors: Chen XL; Department of Obstetrics, Gynecology, and Reproductive Sciences, Moores Cancer Center, Division of Gynecologic Oncology, University of California, San Diego, La Jolla, CA, USA., Tharp KM; Sanford Burnham Prebys Discovery Institute, Cancer Metabolism and Microenvironment Program, La Jolla, CA, USA., Ojalill M; Department of Obstetrics, Gynecology, and Reproductive Sciences, Moores Cancer Center, Division of Gynecologic Oncology, University of California, San Diego, La Jolla, CA, USA., Ozmadenci D; Department of Obstetrics, Gynecology, and Reproductive Sciences, Moores Cancer Center, Division of Gynecologic Oncology, University of California, San Diego, La Jolla, CA, USA., Boyer A; Department of Obstetrics, Gynecology, and Reproductive Sciences, Moores Cancer Center, Division of Gynecologic Oncology, University of California, San Diego, La Jolla, CA, USA., Haanen TJ 3rd; Department of Obstetrics, Gynecology, and Reproductive Sciences, Moores Cancer Center, Division of Gynecologic Oncology, University of California, San Diego, La Jolla, CA, USA., Lawson C; Department of Obstetrics, Gynecology, and Reproductive Sciences, Moores Cancer Center, Division of Gynecologic Oncology, University of California, San Diego, La Jolla, CA, USA., Lee HJ; Department of Obstetrics, Gynecology, and Reproductive Sciences, Moores Cancer Center, Division of Gynecologic Oncology, University of California, San Diego, La Jolla, CA, USA., Xia M; Department of Obstetrics, Gynecology, and Reproductive Sciences, Moores Cancer Center, Division of Gynecologic Oncology, University of California, San Diego, La Jolla, CA, USA., Tahon E; Department of Obstetrics, Gynecology, and Reproductive Sciences, Moores Cancer Center, Division of Gynecologic Oncology, University of California, San Diego, La Jolla, CA, USA., Zhang Y; Department of Obstetrics, Gynecology, and Reproductive Sciences, Moores Cancer Center, Division of Gynecologic Oncology, University of California, San Diego, La Jolla, CA, USA., Minor C; Sanford Burnham Prebys Discovery Institute, Cancer Metabolism and Microenvironment Program, La Jolla, CA, USA., Khan SU; Department of Obstetrics, Gynecology, and Reproductive Sciences, Moores Cancer Center, Division of Gynecologic Oncology, University of California, San Diego, La Jolla, CA, USA., Anderson CC; Department of Biochemistry and Molecular Genetics, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO, USA., Nemkov T; Department of Biochemistry and Molecular Genetics, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO, USA., Rose M; Department of Pathology, Moores Cancer Center, University of California, San Diego, La Jolla, CA, USA., Estrada MV; Department of Pathology, Moores Cancer Center, University of California, San Diego, La Jolla, CA, USA., Molinolo AA; Department of Pathology, Moores Cancer Center, University of California, San Diego, La Jolla, CA, USA., Warren E; Department of Pathology, Moores Cancer Center, University of California, San Diego, La Jolla, CA, USA., Penalosa P; Department of Obstetrics, Gynecology, and Reproductive Sciences, Moores Cancer Center, Division of Gynecologic Oncology, University of California, San Diego, La Jolla, CA, USA., Eskander RN; Department of Obstetrics, Gynecology, and Reproductive Sciences, Moores Cancer Center, Division of Gynecologic Oncology, University of California, San Diego, La Jolla, CA, USA., McHale MT; Department of Obstetrics, Gynecology, and Reproductive Sciences, Moores Cancer Center, Division of Gynecologic Oncology, University of California, San Diego, La Jolla, CA, USA., Wang SE; Department of Pathology, Moores Cancer Center, University of California, San Diego, La Jolla, CA, USA., Connolly DC; Fox Chase Cancer Center, Cancer Signaling and Microenvironment Program, Philadelphia, PA, USA., Fisch KM; Department of Obstetrics, Gynecology, and Reproductive Sciences, Division of Maternal and Fetal Medicine, University of California, San Diego, La Jolla, CA, USA., Stupack DG; Department of Obstetrics, Gynecology, and Reproductive Sciences, Moores Cancer Center, Division of Gynecologic Oncology, University of California, San Diego, La Jolla, CA, USA., Schlaepfer DD; Department of Obstetrics, Gynecology, and Reproductive Sciences, Moores Cancer Center, Division of Gynecologic Oncology, University of California, San Diego, La Jolla, CA, USA. Electronic address: dschlaepfer@health.ucsd.edu.
Source: Cell reports [Cell Rep] 2026 Mar 24; Vol. 45 (3), pp. 117009. Date of Electronic Publication: 2026 Feb 24.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101573691 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2211-1247 (Electronic) NLM ISO Abbreviation: Cell Rep Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2211-1247
DOI:10.1016/j.celrep.2026.117009