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FAK inhibition in ovarian cancer releases omega-3 fatty acids to program CXCL13-producing anti-tumor resident peritoneal macrophages.

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Title: FAK inhibition in ovarian cancer releases omega-3 fatty acids to program CXCL13-producing anti-tumor resident peritoneal macrophages.
Authors: Chen XL; Department of Obstetrics, Gynecology, and Reproductive Sciences, Moores Cancer Center, Division of Gynecologic Oncology, University of California, San Diego, La Jolla, CA, USA., Tharp KM; Sanford Burnham Prebys Discovery Institute, Cancer Metabolism and Microenvironment Program, La Jolla, CA, USA., Ojalill M; Department of Obstetrics, Gynecology, and Reproductive Sciences, Moores Cancer Center, Division of Gynecologic Oncology, University of California, San Diego, La Jolla, CA, USA., Ozmadenci D; Department of Obstetrics, Gynecology, and Reproductive Sciences, Moores Cancer Center, Division of Gynecologic Oncology, University of California, San Diego, La Jolla, CA, USA., Boyer A; Department of Obstetrics, Gynecology, and Reproductive Sciences, Moores Cancer Center, Division of Gynecologic Oncology, University of California, San Diego, La Jolla, CA, USA., Haanen TJ 3rd; Department of Obstetrics, Gynecology, and Reproductive Sciences, Moores Cancer Center, Division of Gynecologic Oncology, University of California, San Diego, La Jolla, CA, USA., Lawson C; Department of Obstetrics, Gynecology, and Reproductive Sciences, Moores Cancer Center, Division of Gynecologic Oncology, University of California, San Diego, La Jolla, CA, USA., Lee HJ; Department of Obstetrics, Gynecology, and Reproductive Sciences, Moores Cancer Center, Division of Gynecologic Oncology, University of California, San Diego, La Jolla, CA, USA., Xia M; Department of Obstetrics, Gynecology, and Reproductive Sciences, Moores Cancer Center, Division of Gynecologic Oncology, University of California, San Diego, La Jolla, CA, USA., Tahon E; Department of Obstetrics, Gynecology, and Reproductive Sciences, Moores Cancer Center, Division of Gynecologic Oncology, University of California, San Diego, La Jolla, CA, USA., Zhang Y; Department of Obstetrics, Gynecology, and Reproductive Sciences, Moores Cancer Center, Division of Gynecologic Oncology, University of California, San Diego, La Jolla, CA, USA., Minor C; Sanford Burnham Prebys Discovery Institute, Cancer Metabolism and Microenvironment Program, La Jolla, CA, USA., Khan SU; Department of Obstetrics, Gynecology, and Reproductive Sciences, Moores Cancer Center, Division of Gynecologic Oncology, University of California, San Diego, La Jolla, CA, USA., Anderson CC; Department of Biochemistry and Molecular Genetics, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO, USA., Nemkov T; Department of Biochemistry and Molecular Genetics, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO, USA., Rose M; Department of Pathology, Moores Cancer Center, University of California, San Diego, La Jolla, CA, USA., Estrada MV; Department of Pathology, Moores Cancer Center, University of California, San Diego, La Jolla, CA, USA., Molinolo AA; Department of Pathology, Moores Cancer Center, University of California, San Diego, La Jolla, CA, USA., Warren E; Department of Pathology, Moores Cancer Center, University of California, San Diego, La Jolla, CA, USA., Penalosa P; Department of Obstetrics, Gynecology, and Reproductive Sciences, Moores Cancer Center, Division of Gynecologic Oncology, University of California, San Diego, La Jolla, CA, USA., Eskander RN; Department of Obstetrics, Gynecology, and Reproductive Sciences, Moores Cancer Center, Division of Gynecologic Oncology, University of California, San Diego, La Jolla, CA, USA., McHale MT; Department of Obstetrics, Gynecology, and Reproductive Sciences, Moores Cancer Center, Division of Gynecologic Oncology, University of California, San Diego, La Jolla, CA, USA., Wang SE; Department of Pathology, Moores Cancer Center, University of California, San Diego, La Jolla, CA, USA., Connolly DC; Fox Chase Cancer Center, Cancer Signaling and Microenvironment Program, Philadelphia, PA, USA., Fisch KM; Department of Obstetrics, Gynecology, and Reproductive Sciences, Division of Maternal and Fetal Medicine, University of California, San Diego, La Jolla, CA, USA., Stupack DG; Department of Obstetrics, Gynecology, and Reproductive Sciences, Moores Cancer Center, Division of Gynecologic Oncology, University of California, San Diego, La Jolla, CA, USA., Schlaepfer DD; Department of Obstetrics, Gynecology, and Reproductive Sciences, Moores Cancer Center, Division of Gynecologic Oncology, University of California, San Diego, La Jolla, CA, USA. Electronic address: dschlaepfer@health.ucsd.edu.
Source: Cell reports [Cell Rep] 2026 Mar 24; Vol. 45 (3), pp. 117009. Date of Electronic Publication: 2026 Feb 24.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101573691 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2211-1247 (Electronic) NLM ISO Abbreviation: Cell Rep Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: FAK inhibition in ovarian cancer releases omega-3 fatty acids to program CXCL13-producing anti-tumor resident peritoneal macrophages.
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  Data: <searchLink fieldCode="AU" term="%22Chen+XL%22">Chen XL</searchLink>; Department of Obstetrics, Gynecology, and Reproductive Sciences, Moores Cancer Center, Division of Gynecologic Oncology, University of California, San Diego, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Tharp+KM%22">Tharp KM</searchLink>; Sanford Burnham Prebys Discovery Institute, Cancer Metabolism and Microenvironment Program, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Ojalill+M%22">Ojalill M</searchLink>; Department of Obstetrics, Gynecology, and Reproductive Sciences, Moores Cancer Center, Division of Gynecologic Oncology, University of California, San Diego, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Ozmadenci+D%22">Ozmadenci D</searchLink>; Department of Obstetrics, Gynecology, and Reproductive Sciences, Moores Cancer Center, Division of Gynecologic Oncology, University of California, San Diego, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Boyer+A%22">Boyer A</searchLink>; Department of Obstetrics, Gynecology, and Reproductive Sciences, Moores Cancer Center, Division of Gynecologic Oncology, University of California, San Diego, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Haanen+TJ+3rd%22">Haanen TJ 3rd</searchLink>; Department of Obstetrics, Gynecology, and Reproductive Sciences, Moores Cancer Center, Division of Gynecologic Oncology, University of California, San Diego, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Lawson+C%22">Lawson C</searchLink>; Department of Obstetrics, Gynecology, and Reproductive Sciences, Moores Cancer Center, Division of Gynecologic Oncology, University of California, San Diego, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Lee+HJ%22">Lee HJ</searchLink>; Department of Obstetrics, Gynecology, and Reproductive Sciences, Moores Cancer Center, Division of Gynecologic Oncology, University of California, San Diego, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Xia+M%22">Xia M</searchLink>; Department of Obstetrics, Gynecology, and Reproductive Sciences, Moores Cancer Center, Division of Gynecologic Oncology, University of California, San Diego, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Tahon+E%22">Tahon E</searchLink>; Department of Obstetrics, Gynecology, and Reproductive Sciences, Moores Cancer Center, Division of Gynecologic Oncology, University of California, San Diego, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Zhang+Y%22">Zhang Y</searchLink>; Department of Obstetrics, Gynecology, and Reproductive Sciences, Moores Cancer Center, Division of Gynecologic Oncology, University of California, San Diego, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Minor+C%22">Minor C</searchLink>; Sanford Burnham Prebys Discovery Institute, Cancer Metabolism and Microenvironment Program, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Khan+SU%22">Khan SU</searchLink>; Department of Obstetrics, Gynecology, and Reproductive Sciences, Moores Cancer Center, Division of Gynecologic Oncology, University of California, San Diego, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Anderson+CC%22">Anderson CC</searchLink>; Department of Biochemistry and Molecular Genetics, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO, USA.<br /><searchLink fieldCode="AU" term="%22Nemkov+T%22">Nemkov T</searchLink>; Department of Biochemistry and Molecular Genetics, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO, USA.<br /><searchLink fieldCode="AU" term="%22Rose+M%22">Rose M</searchLink>; Department of Pathology, Moores Cancer Center, University of California, San Diego, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Estrada+MV%22">Estrada MV</searchLink>; Department of Pathology, Moores Cancer Center, University of California, San Diego, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Molinolo+AA%22">Molinolo AA</searchLink>; Department of Pathology, Moores Cancer Center, University of California, San Diego, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Warren+E%22">Warren E</searchLink>; Department of Pathology, Moores Cancer Center, University of California, San Diego, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Penalosa+P%22">Penalosa P</searchLink>; Department of Obstetrics, Gynecology, and Reproductive Sciences, Moores Cancer Center, Division of Gynecologic Oncology, University of California, San Diego, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Eskander+RN%22">Eskander RN</searchLink>; Department of Obstetrics, Gynecology, and Reproductive Sciences, Moores Cancer Center, Division of Gynecologic Oncology, University of California, San Diego, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22McHale+MT%22">McHale MT</searchLink>; Department of Obstetrics, Gynecology, and Reproductive Sciences, Moores Cancer Center, Division of Gynecologic Oncology, University of California, San Diego, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Wang+SE%22">Wang SE</searchLink>; Department of Pathology, Moores Cancer Center, University of California, San Diego, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Connolly+DC%22">Connolly DC</searchLink>; Fox Chase Cancer Center, Cancer Signaling and Microenvironment Program, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Fisch+KM%22">Fisch KM</searchLink>; Department of Obstetrics, Gynecology, and Reproductive Sciences, Division of Maternal and Fetal Medicine, University of California, San Diego, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Stupack+DG%22">Stupack DG</searchLink>; Department of Obstetrics, Gynecology, and Reproductive Sciences, Moores Cancer Center, Division of Gynecologic Oncology, University of California, San Diego, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Schlaepfer+DD%22">Schlaepfer DD</searchLink>; Department of Obstetrics, Gynecology, and Reproductive Sciences, Moores Cancer Center, Division of Gynecologic Oncology, University of California, San Diego, La Jolla, CA, USA. Electronic address: dschlaepfer@health.ucsd.edu.
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  Data: <searchLink fieldCode="JN" term="%22101573691%22">Cell reports</searchLink> [Cell Rep] 2026 Mar 24; Vol. 45 (3), pp. 117009. <i>Date of Electronic Publication: </i>2026 Feb 24.
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