Personalized signaling pathway analysis of gastrointestinal tumors for patient stratification and drug target evaluation using clinically derived core biopsies.

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Title: Personalized signaling pathway analysis of gastrointestinal tumors for patient stratification and drug target evaluation using clinically derived core biopsies.
Authors: Stahl A; NMI Natural and Medical Sciences Institute at the University of Tübingen, Reutlingen, Germany. aaron.m.stahl@gmx.de.; Institute of Biomedical Engineering, Department for Medical Technologies and Regenerative Medicine, University of Tübingen, Tübingen, Germany. aaron.m.stahl@gmx.de., Büringer K; Department of Internal Medicine I, University Hospital Tübingen, Tübingen, Germany., Missios P; Department of Internal Medicine I, University Hospital Tübingen, Tübingen, Germany.; Center for Personalized Medicine, Eberhard-Karls University, Tübingen, Germany., Hoffmann T; Department of Internal Medicine I, University Hospital Tübingen, Tübingen, Germany., Mattern S; Department of Pathology and Neuropathology, University Hospital Tübingen, Tübingen, Germany., Singer S; Department of Pathology and Neuropathology, University Hospital Tübingen, Tübingen, Germany., Schäfer-Ruoff F; NMI Natural and Medical Sciences Institute at the University of Tübingen, Reutlingen, Germany., Malek NP; Department of Internal Medicine I, University Hospital Tübingen, Tübingen, Germany.; Center for Personalized Medicine, Eberhard-Karls University, Tübingen, Germany.; M3-Research Center for Malignome, Metabolome and Microbiome, Eberhard-Karls University, Tübingen, Germany., Schenke-Layland K; NMI Natural and Medical Sciences Institute at the University of Tübingen, Reutlingen, Germany.; Institute of Biomedical Engineering, Department for Medical Technologies and Regenerative Medicine, University of Tübingen, Tübingen, Germany., Bitzer M; Department of Internal Medicine I, University Hospital Tübingen, Tübingen, Germany. m.bitzer@med.uni-tuebingen.de.; Center for Personalized Medicine, Eberhard-Karls University, Tübingen, Germany. m.bitzer@med.uni-tuebingen.de.; M3-Research Center for Malignome, Metabolome and Microbiome, Eberhard-Karls University, Tübingen, Germany. m.bitzer@med.uni-tuebingen.de., Templin MF; NMI Natural and Medical Sciences Institute at the University of Tübingen, Reutlingen, Germany. markus.templin@nmi.de.
Source: NPJ precision oncology [NPJ Precis Oncol] 2026 Feb 25; Vol. 10 (1). Date of Electronic Publication: 2026 Feb 25.
Publication Type: Journal Article
Journal Info: Publisher: Springer Nature Country of Publication: England NLM ID: 101708166 Publication Model: Electronic Cited Medium: Print ISSN: 2397-768X (Print) Linking ISSN: 2397768X NLM ISO Abbreviation: NPJ Precis Oncol Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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Description
ISSN:2397-768X
DOI:10.1038/s41698-026-01304-5