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Real-world longitudinal validation of high-income-country-derived sepsis endotypes in sub-Saharan Africa: a nested prospective multicenter study.

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Title: Real-world longitudinal validation of high-income-country-derived sepsis endotypes in sub-Saharan Africa: a nested prospective multicenter study.
Authors: Turgman O; Center for Infection and Molecular Medicine, Amsterdam UMC, Amsterdam Institute for Infection and Immunity, University of Amsterdam, Amsterdam, The Netherlands. o.turgman@amsterdamumc.nl., Butler JM; Center for Infection and Molecular Medicine, Amsterdam UMC, Amsterdam Institute for Infection and Immunity, University of Amsterdam, Amsterdam, The Netherlands., Haguma P; Walimu, Kampala, Uganda., Nyesiga S; Walimu, Kampala, Uganda., Phulusa J; Malawi-Liverpool Wellcome, Blantyre, Malawi., Carey L; Department of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, UK., Rylance J; Department of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, UK., van der Poll T; Center for Infection and Molecular Medicine, Amsterdam UMC, Amsterdam Institute for Infection and Immunity, University of Amsterdam, Amsterdam, The Netherlands.; Department of Medicine, Division of Infectious Diseases, Amsterdam UMC, location Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands., Wiersinga WJ; Center for Infection and Molecular Medicine, Amsterdam UMC, Amsterdam Institute for Infection and Immunity, University of Amsterdam, Amsterdam, The Netherlands.; Department of Medicine, Division of Infectious Diseases, Amsterdam UMC, location Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands., Jacob ST; Walimu, Kampala, Uganda.; Department of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, UK.
Source: Critical care (London, England) [Crit Care] 2026 Feb 25; Vol. 30 (1). Date of Electronic Publication: 2026 Feb 25.
Publication Type: Journal Article; Multicenter Study
Journal Info: Publisher: BioMed Central Ltd Country of Publication: England NLM ID: 9801902 Publication Model: Electronic Cited Medium: Internet ISSN: 1466-609X (Electronic) Linking ISSN: 13648535 NLM ISO Abbreviation: Crit Care Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Turgman+O%22">Turgman O</searchLink>; Center for Infection and Molecular Medicine, Amsterdam UMC, Amsterdam Institute for Infection and Immunity, University of Amsterdam, Amsterdam, The Netherlands. o.turgman@amsterdamumc.nl.<br /><searchLink fieldCode="AU" term="%22Butler+JM%22">Butler JM</searchLink>; Center for Infection and Molecular Medicine, Amsterdam UMC, Amsterdam Institute for Infection and Immunity, University of Amsterdam, Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Haguma+P%22">Haguma P</searchLink>; Walimu, Kampala, Uganda.<br /><searchLink fieldCode="AU" term="%22Nyesiga+S%22">Nyesiga S</searchLink>; Walimu, Kampala, Uganda.<br /><searchLink fieldCode="AU" term="%22Phulusa+J%22">Phulusa J</searchLink>; Malawi-Liverpool Wellcome, Blantyre, Malawi.<br /><searchLink fieldCode="AU" term="%22Carey+L%22">Carey L</searchLink>; Department of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, UK.<br /><searchLink fieldCode="AU" term="%22Rylance+J%22">Rylance J</searchLink>; Department of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, UK.<br /><searchLink fieldCode="AU" term="%22van+der+Poll+T%22">van der Poll T</searchLink>; Center for Infection and Molecular Medicine, Amsterdam UMC, Amsterdam Institute for Infection and Immunity, University of Amsterdam, Amsterdam, The Netherlands.; Department of Medicine, Division of Infectious Diseases, Amsterdam UMC, location Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Wiersinga+WJ%22">Wiersinga WJ</searchLink>; Center for Infection and Molecular Medicine, Amsterdam UMC, Amsterdam Institute for Infection and Immunity, University of Amsterdam, Amsterdam, The Netherlands.; Department of Medicine, Division of Infectious Diseases, Amsterdam UMC, location Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Jacob+ST%22">Jacob ST</searchLink>; Walimu, Kampala, Uganda.; Department of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, UK.
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  Data: <searchLink fieldCode="JN" term="%229801902%22">Critical care (London, England)</searchLink> [Crit Care] 2026 Feb 25; Vol. 30 (1). <i>Date of Electronic Publication: </i>2026 Feb 25.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22BioMed+Central+Ltd%22">BioMed Central Ltd </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>9801902 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1466-609X (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2213648535%22">13648535 </searchLink><i>NLM ISO Abbreviation: </i>Crit Care <i>Subsets: </i>MEDLINE
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        Value: 10.1186/s13054-026-05901-5
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              Text: 2026 Feb 25
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