Ubenimex synergizes with the PD-L1 blockade in gastric cancer by competitively binding LAP3 with UBE3A.
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| Title: | Ubenimex synergizes with the PD-L1 blockade in gastric cancer by competitively binding LAP3 with UBE3A. |
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| Authors: | Zhao C; School of Basic Medicine, Institute of Cancer Biology, Shanxi Medical University, Jinzhong, 030600, China.; Department of Pathology, Heping Hospital affiliated with Changzhi Medical College, Changzhi, 046000, China.; Department of Pathology, Changzhi Medical College, Changzhi, 046000, China., Li J; School of Basic Medicine, Institute of Cancer Biology, Shanxi Medical University, Jinzhong, 030600, China., Zheng J; School of Basic Medicine, Institute of Cancer Biology, Shanxi Medical University, Jinzhong, 030600, China., Chi M; School of Basic Medicine, Institute of Cancer Biology, Shanxi Medical University, Jinzhong, 030600, China., Shao Y; School of Basic Medicine, Institute of Cancer Biology, Shanxi Medical University, Jinzhong, 030600, China.; Shanxi Center of Technology Innovation for Biomolecular Imaging & Precision Oncology, Jinzhong, 030600, China., Che Y; School of Basic Medicine, Institute of Cancer Biology, Shanxi Medical University, Jinzhong, 030600, China.; Shanxi Center of Technology Innovation for Biomolecular Imaging & Precision Oncology, Jinzhong, 030600, China., Chen W; School of Basic Medicine, Institute of Cancer Biology, Shanxi Medical University, Jinzhong, 030600, China.; Shanxi Center of Technology Innovation for Biomolecular Imaging & Precision Oncology, Jinzhong, 030600, China., Dai J; School of Basic Medicine, Institute of Cancer Biology, Shanxi Medical University, Jinzhong, 030600, China., Chen C; Institute of Medical Technology, Shanxi Medical University, Taiyuan, 030001, China., Li X; Department of Biochemistry & Molecular Biology, Shanxi Medical University, Taiyuan, 030001, China., Zan L; Department of Pathology, The Affiliated Cancer Hospital of Shanxi Medical University, Taiyuan, Shanxi, China., Shi Y; School of Basic Medicine, Institute of Cancer Biology, Shanxi Medical University, Jinzhong, 030600, China.; Shanxi Center of Technology Innovation for Biomolecular Imaging & Precision Oncology, Jinzhong, 030600, China., Duan Y; School of Basic Medicine, Institute of Cancer Biology, Shanxi Medical University, Jinzhong, 030600, China.; Shanxi Center of Technology Innovation for Biomolecular Imaging & Precision Oncology, Jinzhong, 030600, China., Yang L; Department of Pharmacology, Shanxi University of Medicine, Fenyang, 032200, China. yanglijunmm@126.com.; Ministry of Education Key laboratory of Cellular Physiology, Shanxi Medical University, Taiyuan, 030001, China. yanglijunmm@126.com., Yang T; Key laboratory of Digestive Disease & Organ Transplantation in Shanxi Province, The First Hospital of Shanxi Medical University, Taiyuan, 030000, Shanxi, China. yangtao056cn@sxmu.edu.cn.; Ministry of Education Key Laboratory of Coal Environmental Pathogenicity and Prevention, School of Public Health, Shanxi Medical University, Taiyuan, 030001, China. yangtao056cn@sxmu.edu.cn.; Collaborative Innovation Center for Molecular Imaging of Precision Medicine, Shanxi Medical University, Taiyuan, 030001, China. yangtao056cn@sxmu.edu.cn. |
| Source: | Cell death & disease [Cell Death Dis] 2026 Feb 26; Vol. 17 (1). Date of Electronic Publication: 2026 Feb 26. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101524092 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-4889 (Electronic) NLM ISO Abbreviation: Cell Death Dis Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2041-4889 |
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| DOI: | 10.1038/s41419-026-08509-3 |
