UBE3A-mediated mH2A1 Ubiquitination activates TERT transcription to promote senescence resistance in pancreatic cancer.
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| Title: | UBE3A-mediated mH2A1 Ubiquitination activates TERT transcription to promote senescence resistance in pancreatic cancer. |
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| Authors: | Ren L; School of Clinical Medicine, Guizhou Medical University, Guiyang, Guizhou, China., Lu R; School of Clinical Medicine, Guizhou Medical University, Guiyang, Guizhou, China., Fei X; Department of Hepatobiliary Surgery, Zhejiang Provincial People's Hospital, Hangzhou, Zhejiang, China., Chen S; School of Clinical Medicine, Guizhou Medical University, Guiyang, Guizhou, China.; Department of Hepatobiliary Surgery, Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou, China., Liu P; Department of Hepatobiliary Surgery, Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou, China., Liu S; Department of Hepatobiliary Surgery, Baiyun Hospital of Guizhou Medical University, Guiyang, Guizhou, China., Zhu C; Department of Hepatobiliary Surgery, Affiliated Cancer Hospital of Guizhou Medical University, Guiyang, Guizhou, China., Shen X; Guizhou International Science & Technology Cooperation Base for Druggability Research of Natural Medicinesm, Guizhou Medical University, Guiyang, Guizhou, China.; The High Efficacy Application of Natural Medicinal Resources Engineering Center of Guizhou Province, Guizhou Medical University, Guiyang, Guizhou, China.; The Key Laboratory of Optimal Utilization of Natural Medicine Resources, Guizhou Medical University, Guiyang, Guizhou, China., Wang X; School of Clinical Medicine, Guizhou Medical University, Guiyang, Guizhou, China.; Department of Hepatobiliary Surgery, Affiliated Cancer Hospital of Guizhou Medical University, Guiyang, Guizhou, China., Pan Y; School of Clinical Medicine, Guizhou Medical University, Guiyang, Guizhou, China. panyaozhen112@163.com.; Department of Hepatobiliary Surgery, Affiliated Cancer Hospital of Guizhou Medical University, Guiyang, Guizhou, China. panyaozhen112@163.com. |
| Source: | Cell death & disease [Cell Death Dis] 2026 Feb 26; Vol. 17 (1). Date of Electronic Publication: 2026 Feb 26. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101524092 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-4889 (Electronic) NLM ISO Abbreviation: Cell Death Dis Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2041-4889 |
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| DOI: | 10.1038/s41419-026-08480-z |
