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UBE3A-mediated mH2A1 Ubiquitination activates TERT transcription to promote senescence resistance in pancreatic cancer.

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Title: UBE3A-mediated mH2A1 Ubiquitination activates TERT transcription to promote senescence resistance in pancreatic cancer.
Authors: Ren L; School of Clinical Medicine, Guizhou Medical University, Guiyang, Guizhou, China., Lu R; School of Clinical Medicine, Guizhou Medical University, Guiyang, Guizhou, China., Fei X; Department of Hepatobiliary Surgery, Zhejiang Provincial People's Hospital, Hangzhou, Zhejiang, China., Chen S; School of Clinical Medicine, Guizhou Medical University, Guiyang, Guizhou, China.; Department of Hepatobiliary Surgery, Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou, China., Liu P; Department of Hepatobiliary Surgery, Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou, China., Liu S; Department of Hepatobiliary Surgery, Baiyun Hospital of Guizhou Medical University, Guiyang, Guizhou, China., Zhu C; Department of Hepatobiliary Surgery, Affiliated Cancer Hospital of Guizhou Medical University, Guiyang, Guizhou, China., Shen X; Guizhou International Science & Technology Cooperation Base for Druggability Research of Natural Medicinesm, Guizhou Medical University, Guiyang, Guizhou, China.; The High Efficacy Application of Natural Medicinal Resources Engineering Center of Guizhou Province, Guizhou Medical University, Guiyang, Guizhou, China.; The Key Laboratory of Optimal Utilization of Natural Medicine Resources, Guizhou Medical University, Guiyang, Guizhou, China., Wang X; School of Clinical Medicine, Guizhou Medical University, Guiyang, Guizhou, China.; Department of Hepatobiliary Surgery, Affiliated Cancer Hospital of Guizhou Medical University, Guiyang, Guizhou, China., Pan Y; School of Clinical Medicine, Guizhou Medical University, Guiyang, Guizhou, China. panyaozhen112@163.com.; Department of Hepatobiliary Surgery, Affiliated Cancer Hospital of Guizhou Medical University, Guiyang, Guizhou, China. panyaozhen112@163.com.
Source: Cell death & disease [Cell Death Dis] 2026 Feb 26; Vol. 17 (1). Date of Electronic Publication: 2026 Feb 26.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101524092 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-4889 (Electronic) NLM ISO Abbreviation: Cell Death Dis Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: UBE3A-mediated mH2A1 Ubiquitination activates TERT transcription to promote senescence resistance in pancreatic cancer.
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  Data: <searchLink fieldCode="AU" term="%22Ren+L%22">Ren L</searchLink>; School of Clinical Medicine, Guizhou Medical University, Guiyang, Guizhou, China.<br /><searchLink fieldCode="AU" term="%22Lu+R%22">Lu R</searchLink>; School of Clinical Medicine, Guizhou Medical University, Guiyang, Guizhou, China.<br /><searchLink fieldCode="AU" term="%22Fei+X%22">Fei X</searchLink>; Department of Hepatobiliary Surgery, Zhejiang Provincial People's Hospital, Hangzhou, Zhejiang, China.<br /><searchLink fieldCode="AU" term="%22Chen+S%22">Chen S</searchLink>; School of Clinical Medicine, Guizhou Medical University, Guiyang, Guizhou, China.; Department of Hepatobiliary Surgery, Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou, China.<br /><searchLink fieldCode="AU" term="%22Liu+P%22">Liu P</searchLink>; Department of Hepatobiliary Surgery, Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou, China.<br /><searchLink fieldCode="AU" term="%22Liu+S%22">Liu S</searchLink>; Department of Hepatobiliary Surgery, Baiyun Hospital of Guizhou Medical University, Guiyang, Guizhou, China.<br /><searchLink fieldCode="AU" term="%22Zhu+C%22">Zhu C</searchLink>; Department of Hepatobiliary Surgery, Affiliated Cancer Hospital of Guizhou Medical University, Guiyang, Guizhou, China.<br /><searchLink fieldCode="AU" term="%22Shen+X%22">Shen X</searchLink>; Guizhou International Science & Technology Cooperation Base for Druggability Research of Natural Medicinesm, Guizhou Medical University, Guiyang, Guizhou, China.; The High Efficacy Application of Natural Medicinal Resources Engineering Center of Guizhou Province, Guizhou Medical University, Guiyang, Guizhou, China.; The Key Laboratory of Optimal Utilization of Natural Medicine Resources, Guizhou Medical University, Guiyang, Guizhou, China.<br /><searchLink fieldCode="AU" term="%22Wang+X%22">Wang X</searchLink>; School of Clinical Medicine, Guizhou Medical University, Guiyang, Guizhou, China.; Department of Hepatobiliary Surgery, Affiliated Cancer Hospital of Guizhou Medical University, Guiyang, Guizhou, China.<br /><searchLink fieldCode="AU" term="%22Pan+Y%22">Pan Y</searchLink>; School of Clinical Medicine, Guizhou Medical University, Guiyang, Guizhou, China. panyaozhen112@163.com.; Department of Hepatobiliary Surgery, Affiliated Cancer Hospital of Guizhou Medical University, Guiyang, Guizhou, China. panyaozhen112@163.com.
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  Data: <searchLink fieldCode="JN" term="%22101524092%22">Cell death & disease</searchLink> [Cell Death Dis] 2026 Feb 26; Vol. 17 (1). <i>Date of Electronic Publication: </i>2026 Feb 26.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Pub%2E+Group%22">Nature Pub. Group </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101524092 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2041-4889 (Electronic) <i>NLM ISO Abbreviation: </i>Cell Death Dis <i>Subsets: </i>MEDLINE
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=41748542
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        Value: 10.1038/s41419-026-08480-z
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              Text: 2026 Feb 26
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