Rapamycin Reduces Amyloid-β Plaques and Improves Behavioral Performance in a Sex-Dependent Manner in Mouse Models of Amyloidosis.

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Title: Rapamycin Reduces Amyloid-β Plaques and Improves Behavioral Performance in a Sex-Dependent Manner in Mouse Models of Amyloidosis.
Authors: Guo S; Department of Neurobiology, School of Basic Medical Sciences, Chongqing Medical University, Chongqing, China.; Key Laboratory of Major Brain Disease and Aging Research (Ministry of Education), The First Affiliated Hospital of Chongqing Medical University, Chongqing, China., Fu W; Department of Neurobiology, School of Basic Medical Sciences, Chongqing Medical University, Chongqing, China.; Key Laboratory of Major Brain Disease and Aging Research (Ministry of Education), The First Affiliated Hospital of Chongqing Medical University, Chongqing, China., Wang Y; Department of Neurobiology, School of Basic Medical Sciences, Chongqing Medical University, Chongqing, China.; Key Laboratory of Major Brain Disease and Aging Research (Ministry of Education), The First Affiliated Hospital of Chongqing Medical University, Chongqing, China., Liu Q; Department of Neurobiology, School of Basic Medical Sciences, Chongqing Medical University, Chongqing, China.; Key Laboratory of Major Brain Disease and Aging Research (Ministry of Education), The First Affiliated Hospital of Chongqing Medical University, Chongqing, China., Li J; Department of Neurobiology, School of Basic Medical Sciences, Chongqing Medical University, Chongqing, China.; Key Laboratory of Major Brain Disease and Aging Research (Ministry of Education), The First Affiliated Hospital of Chongqing Medical University, Chongqing, China., Guo K; Key Laboratory of Major Brain Disease and Aging Research (Ministry of Education), The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.; Department of Psychiatry, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China., Zhang H; Department of Neurobiology, School of Basic Medical Sciences, Chongqing Medical University, Chongqing, China.; Key Laboratory of Major Brain Disease and Aging Research (Ministry of Education), The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.; Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Source: CNS neuroscience & therapeutics [CNS Neurosci Ther] 2026 Mar; Vol. 32 (3), pp. e70807.
Publication Type: Journal Article
Journal Info: Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 101473265 Publication Model: Print Cited Medium: Internet ISSN: 1755-5949 (Electronic) Linking ISSN: 17555930 NLM ISO Abbreviation: CNS Neurosci Ther Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1755-5949
DOI:10.1002/cns.70807