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Rapamycin Reduces Amyloid-β Plaques and Improves Behavioral Performance in a Sex-Dependent Manner in Mouse Models of Amyloidosis.

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Title: Rapamycin Reduces Amyloid-β Plaques and Improves Behavioral Performance in a Sex-Dependent Manner in Mouse Models of Amyloidosis.
Authors: Guo S; Department of Neurobiology, School of Basic Medical Sciences, Chongqing Medical University, Chongqing, China.; Key Laboratory of Major Brain Disease and Aging Research (Ministry of Education), The First Affiliated Hospital of Chongqing Medical University, Chongqing, China., Fu W; Department of Neurobiology, School of Basic Medical Sciences, Chongqing Medical University, Chongqing, China.; Key Laboratory of Major Brain Disease and Aging Research (Ministry of Education), The First Affiliated Hospital of Chongqing Medical University, Chongqing, China., Wang Y; Department of Neurobiology, School of Basic Medical Sciences, Chongqing Medical University, Chongqing, China.; Key Laboratory of Major Brain Disease and Aging Research (Ministry of Education), The First Affiliated Hospital of Chongqing Medical University, Chongqing, China., Liu Q; Department of Neurobiology, School of Basic Medical Sciences, Chongqing Medical University, Chongqing, China.; Key Laboratory of Major Brain Disease and Aging Research (Ministry of Education), The First Affiliated Hospital of Chongqing Medical University, Chongqing, China., Li J; Department of Neurobiology, School of Basic Medical Sciences, Chongqing Medical University, Chongqing, China.; Key Laboratory of Major Brain Disease and Aging Research (Ministry of Education), The First Affiliated Hospital of Chongqing Medical University, Chongqing, China., Guo K; Key Laboratory of Major Brain Disease and Aging Research (Ministry of Education), The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.; Department of Psychiatry, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China., Zhang H; Department of Neurobiology, School of Basic Medical Sciences, Chongqing Medical University, Chongqing, China.; Key Laboratory of Major Brain Disease and Aging Research (Ministry of Education), The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.; Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Source: CNS neuroscience & therapeutics [CNS Neurosci Ther] 2026 Mar; Vol. 32 (3), pp. e70807.
Publication Type: Journal Article
Journal Info: Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 101473265 Publication Model: Print Cited Medium: Internet ISSN: 1755-5949 (Electronic) Linking ISSN: 17555930 NLM ISO Abbreviation: CNS Neurosci Ther Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Rapamycin Reduces Amyloid-β Plaques and Improves Behavioral Performance in a Sex-Dependent Manner in Mouse Models of Amyloidosis.
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  Data: <searchLink fieldCode="AU" term="%22Guo+S%22">Guo S</searchLink>; Department of Neurobiology, School of Basic Medical Sciences, Chongqing Medical University, Chongqing, China.; Key Laboratory of Major Brain Disease and Aging Research (Ministry of Education), The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.<br /><searchLink fieldCode="AU" term="%22Fu+W%22">Fu W</searchLink>; Department of Neurobiology, School of Basic Medical Sciences, Chongqing Medical University, Chongqing, China.; Key Laboratory of Major Brain Disease and Aging Research (Ministry of Education), The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.<br /><searchLink fieldCode="AU" term="%22Wang+Y%22">Wang Y</searchLink>; Department of Neurobiology, School of Basic Medical Sciences, Chongqing Medical University, Chongqing, China.; Key Laboratory of Major Brain Disease and Aging Research (Ministry of Education), The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.<br /><searchLink fieldCode="AU" term="%22Liu+Q%22">Liu Q</searchLink>; Department of Neurobiology, School of Basic Medical Sciences, Chongqing Medical University, Chongqing, China.; Key Laboratory of Major Brain Disease and Aging Research (Ministry of Education), The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.<br /><searchLink fieldCode="AU" term="%22Li+J%22">Li J</searchLink>; Department of Neurobiology, School of Basic Medical Sciences, Chongqing Medical University, Chongqing, China.; Key Laboratory of Major Brain Disease and Aging Research (Ministry of Education), The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.<br /><searchLink fieldCode="AU" term="%22Guo+K%22">Guo K</searchLink>; Key Laboratory of Major Brain Disease and Aging Research (Ministry of Education), The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.; Department of Psychiatry, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.<br /><searchLink fieldCode="AU" term="%22Zhang+H%22">Zhang H</searchLink>; Department of Neurobiology, School of Basic Medical Sciences, Chongqing Medical University, Chongqing, China.; Key Laboratory of Major Brain Disease and Aging Research (Ministry of Education), The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.; Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
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  Data: <searchLink fieldCode="JN" term="%22101473265%22">CNS neuroscience & therapeutics</searchLink> [CNS Neurosci Ther] 2026 Mar; Vol. 32 (3), pp. e70807.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Wiley-Blackwell%22">Wiley-Blackwell </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101473265 <i>Publication Model: </i>Print <i>Cited Medium: </i>Internet <i>ISSN: </i>1755-5949 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2217555930%22">17555930 </searchLink><i>NLM ISO Abbreviation: </i>CNS Neurosci Ther <i>Subsets: </i>MEDLINE
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              Text: 2026 Mar
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              Y: 2026
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