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Human Cytomegalovirus Serostatus Defines Cytokine-Based Predictive Signatures in Sepsis.

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Title: Human Cytomegalovirus Serostatus Defines Cytokine-Based Predictive Signatures in Sepsis.
Authors: Krause F; Ruhr University Bochum, Knappschaft Kliniken University Hospital Bochum, Department of Anesthesiology, Intensive Care Medicine and Pain Therapy, 44892 Bochum, Germany., Dyck B; Ruhr University Bochum, Knappschaft Kliniken University Hospital Bochum, Department of Anesthesiology, Intensive Care Medicine and Pain Therapy, Center for Perioperative Precision Medicine, 44892 Bochum, Germany., Kappler K; Ruhr University Bochum, Knappschaft Kliniken University Hospital Bochum, Department of Anesthesiology, Intensive Care Medicine and Pain Therapy, Center for Artificial Intelligence, Medical Informatics and Data Science, 44892 Bochum, Germany., Unterberg M; Ruhr University Bochum, Knappschaft Kliniken University Hospital Bochum, Department of Anesthesiology, Intensive Care Medicine and Pain Therapy, 44892 Bochum, Germany., Nowak H; Ruhr University Bochum, Knappschaft Kliniken University Hospital Bochum, Department of Anesthesiology, Intensive Care Medicine and Pain Therapy, 44892 Bochum, Germany.; Ruhr University Bochum, Knappschaft Kliniken University Hospital Bochum, Department of Anesthesiology, Intensive Care Medicine and Pain Therapy, Center for Artificial Intelligence, Medical Informatics and Data Science, 44892 Bochum, Germany., Rahmel T; Ruhr University Bochum, Knappschaft Kliniken University Hospital Bochum, Department of Anesthesiology, Intensive Care Medicine and Pain Therapy, 44892 Bochum, Germany., Bergmann L; Ruhr University Bochum, Knappschaft Kliniken University Hospital Bochum, Department of Anesthesiology, Intensive Care Medicine and Pain Therapy, 44892 Bochum, Germany., Palmowski L; Ruhr University Bochum, Knappschaft Kliniken University Hospital Bochum, Department of Anesthesiology, Intensive Care Medicine and Pain Therapy, 44892 Bochum, Germany., Westhus B; Ruhr University Bochum, Knappschaft Kliniken University Hospital Bochum, Department of Anesthesiology, Intensive Care Medicine and Pain Therapy, 44892 Bochum, Germany., Wolf A; Ruhr University Bochum, Knappschaft Kliniken University Hospital Bochum, Department of Anesthesiology, Intensive Care Medicine and Pain Therapy, 44892 Bochum, Germany., Busch AV; Ruhr University Bochum, Knappschaft Kliniken University Hospital Bochum, Department of Anesthesiology, Intensive Care Medicine and Pain Therapy, 44892 Bochum, Germany., Sitek B; Ruhr University Bochum, Knappschaft Kliniken University Hospital Bochum, Department of Anesthesiology, Intensive Care Medicine and Pain Therapy, Center for Clinical Proteomic and Metabolomic, 44892 Bochum, Germany.; Ruhr University Bochum, Medical Faculty, Medizinisches Proteom-Center, 44801 Bochum, Germany., Thon P; Ruhr University Bochum, Knappschaft Kliniken University Hospital Bochum, Department of Anesthesiology, Intensive Care Medicine and Pain Therapy, Center for Perioperative Precision Medicine, 44892 Bochum, Germany., Rump K; Ruhr University Bochum, Knappschaft Kliniken University Hospital Bochum, Department of Anesthesiology, Intensive Care Medicine and Pain Therapy, Center for Perioperative Precision Medicine, 44892 Bochum, Germany., Ziehe D; Ruhr University Bochum, Knappschaft Kliniken University Hospital Bochum, Department of Anesthesiology, Intensive Care Medicine and Pain Therapy, Center for Perioperative Precision Medicine, 44892 Bochum, Germany., Wappler F; Department of Anaesthesiology and Critical Care Medicine, Merheim Medical Center, Witten/Herdecke University, 51109 Cologne, Germany., Putensen C; Klinik für Anästhesiologie und Operative Intensivmedizin, Universitätsklinikum Bonn, 53127 Bonn, Germany., Ehrentraut SF; Klinik für Anästhesiologie und Operative Intensivmedizin, Universitätsklinikum Bonn, 53127 Bonn, Germany., Zarbock A; Department of Anesthesiology, Intensive Care and Pain Medicine, University Hospital Münster, 48149 Münster, Germany., Henzler D; Klinikum Herford, Department of Anesthesiology, Surgical Intensive Care, Emergency and Pain Medicine, Ruhr University Bochum, 32049 Herford, Germany., Babel N; Centrum für Translationale Medizin mit Schwerpunkt Immunologie und Transplantation, Marien Hospital Herne, Universitätsklinikum der Ruhr-Universität Bochum, 44625 Herne, Germany., Eisenacher M; Ruhr University Bochum, Medical Faculty, Medizinisches Proteom-Center, 44801 Bochum, Germany.; Ruhr University Bochum, Medical Faculty, CUBiMed.RUB, Core Unit Bioinformatics, 44801 Bochum, Germany.; Ruhr University Bochum, Medical Proteome Analysis, Center for Proteindiagnostics (PRODI), 44801 Bochum, Germany., Marcus K; Ruhr University Bochum, Medical Faculty, Medizinisches Proteom-Center, 44801 Bochum, Germany., Ellger B; Department of Anesthesiology, Intensive Care and Pain Medicine, Klinikum Westfalen, 44309 Dortmund, Germany., Koos B; Ruhr University Bochum, Knappschaft Kliniken University Hospital Bochum, Department of Anesthesiology, Intensive Care Medicine and Pain Therapy, Center for Perioperative Precision Medicine, 44892 Bochum, Germany., Adamzik M; Ruhr University Bochum, Knappschaft Kliniken University Hospital Bochum, Department of Anesthesiology, Intensive Care Medicine and Pain Therapy, 44892 Bochum, Germany., Witowski A; Ruhr University Bochum, Knappschaft Kliniken University Hospital Bochum, Department of Anesthesiology, Intensive Care Medicine and Pain Therapy, 44892 Bochum, Germany.; Ruhr University Bochum, Knappschaft Kliniken University Hospital Bochum, Department of Anesthesiology, Intensive Care Medicine and Pain Therapy, Center for Perioperative Precision Medicine, 44892 Bochum, Germany.
Source: Pathogens (Basel, Switzerland) [Pathogens] 2026 Jan 24; Vol. 15 (2). Date of Electronic Publication: 2026 Jan 24.
Publication Type: Journal Article; Multicenter Study
Journal Info: Publisher: MDPI AG Country of Publication: Switzerland NLM ID: 101596317 Publication Model: Electronic Cited Medium: Internet ISSN: 2076-0817 (Electronic) Linking ISSN: 20760817 NLM ISO Abbreviation: Pathogens Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Human Cytomegalovirus Serostatus Defines Cytokine-Based Predictive Signatures in Sepsis.
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  Data: <searchLink fieldCode="AU" term="%22Krause+F%22">Krause F</searchLink>; Ruhr University Bochum, Knappschaft Kliniken University Hospital Bochum, Department of Anesthesiology, Intensive Care Medicine and Pain Therapy, 44892 Bochum, Germany.<br /><searchLink fieldCode="AU" term="%22Dyck+B%22">Dyck B</searchLink>; Ruhr University Bochum, Knappschaft Kliniken University Hospital Bochum, Department of Anesthesiology, Intensive Care Medicine and Pain Therapy, Center for Perioperative Precision Medicine, 44892 Bochum, Germany.<br /><searchLink fieldCode="AU" term="%22Kappler+K%22">Kappler K</searchLink>; Ruhr University Bochum, Knappschaft Kliniken University Hospital Bochum, Department of Anesthesiology, Intensive Care Medicine and Pain Therapy, Center for Artificial Intelligence, Medical Informatics and Data Science, 44892 Bochum, Germany.<br /><searchLink fieldCode="AU" term="%22Unterberg+M%22">Unterberg M</searchLink>; Ruhr University Bochum, Knappschaft Kliniken University Hospital Bochum, Department of Anesthesiology, Intensive Care Medicine and Pain Therapy, 44892 Bochum, Germany.<br /><searchLink fieldCode="AU" term="%22Nowak+H%22">Nowak H</searchLink>; Ruhr University Bochum, Knappschaft Kliniken University Hospital Bochum, Department of Anesthesiology, Intensive Care Medicine and Pain Therapy, 44892 Bochum, Germany.; Ruhr University Bochum, Knappschaft Kliniken University Hospital Bochum, Department of Anesthesiology, Intensive Care Medicine and Pain Therapy, Center for Artificial Intelligence, Medical Informatics and Data Science, 44892 Bochum, Germany.<br /><searchLink fieldCode="AU" term="%22Rahmel+T%22">Rahmel T</searchLink>; Ruhr University Bochum, Knappschaft Kliniken University Hospital Bochum, Department of Anesthesiology, Intensive Care Medicine and Pain Therapy, 44892 Bochum, Germany.<br /><searchLink fieldCode="AU" term="%22Bergmann+L%22">Bergmann L</searchLink>; Ruhr University Bochum, Knappschaft Kliniken University Hospital Bochum, Department of Anesthesiology, Intensive Care Medicine and Pain Therapy, 44892 Bochum, Germany.<br /><searchLink fieldCode="AU" term="%22Palmowski+L%22">Palmowski L</searchLink>; Ruhr University Bochum, Knappschaft Kliniken University Hospital Bochum, Department of Anesthesiology, Intensive Care Medicine and Pain Therapy, 44892 Bochum, Germany.<br /><searchLink fieldCode="AU" term="%22Westhus+B%22">Westhus B</searchLink>; Ruhr University Bochum, Knappschaft Kliniken University Hospital Bochum, Department of Anesthesiology, Intensive Care Medicine and Pain Therapy, 44892 Bochum, Germany.<br /><searchLink fieldCode="AU" term="%22Wolf+A%22">Wolf A</searchLink>; Ruhr University Bochum, Knappschaft Kliniken University Hospital Bochum, Department of Anesthesiology, Intensive Care Medicine and Pain Therapy, 44892 Bochum, Germany.<br /><searchLink fieldCode="AU" term="%22Busch+AV%22">Busch AV</searchLink>; Ruhr University Bochum, Knappschaft Kliniken University Hospital Bochum, Department of Anesthesiology, Intensive Care Medicine and Pain Therapy, 44892 Bochum, Germany.<br /><searchLink fieldCode="AU" term="%22Sitek+B%22">Sitek B</searchLink>; Ruhr University Bochum, Knappschaft Kliniken University Hospital Bochum, Department of Anesthesiology, Intensive Care Medicine and Pain Therapy, Center for Clinical Proteomic and Metabolomic, 44892 Bochum, Germany.; Ruhr University Bochum, Medical Faculty, Medizinisches Proteom-Center, 44801 Bochum, Germany.<br /><searchLink fieldCode="AU" term="%22Thon+P%22">Thon P</searchLink>; Ruhr University Bochum, Knappschaft Kliniken University Hospital Bochum, Department of Anesthesiology, Intensive Care Medicine and Pain Therapy, Center for Perioperative Precision Medicine, 44892 Bochum, Germany.<br /><searchLink fieldCode="AU" term="%22Rump+K%22">Rump K</searchLink>; Ruhr University Bochum, Knappschaft Kliniken University Hospital Bochum, Department of Anesthesiology, Intensive Care Medicine and Pain Therapy, Center for Perioperative Precision Medicine, 44892 Bochum, Germany.<br /><searchLink fieldCode="AU" term="%22Ziehe+D%22">Ziehe D</searchLink>; Ruhr University Bochum, Knappschaft Kliniken University Hospital Bochum, Department of Anesthesiology, Intensive Care Medicine and Pain Therapy, Center for Perioperative Precision Medicine, 44892 Bochum, Germany.<br /><searchLink fieldCode="AU" term="%22Wappler+F%22">Wappler F</searchLink>; Department of Anaesthesiology and Critical Care Medicine, Merheim Medical Center, Witten/Herdecke University, 51109 Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Putensen+C%22">Putensen C</searchLink>; Klinik für Anästhesiologie und Operative Intensivmedizin, Universitätsklinikum Bonn, 53127 Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Ehrentraut+SF%22">Ehrentraut SF</searchLink>; Klinik für Anästhesiologie und Operative Intensivmedizin, Universitätsklinikum Bonn, 53127 Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Zarbock+A%22">Zarbock A</searchLink>; Department of Anesthesiology, Intensive Care and Pain Medicine, University Hospital Münster, 48149 Münster, Germany.<br /><searchLink fieldCode="AU" term="%22Henzler+D%22">Henzler D</searchLink>; Klinikum Herford, Department of Anesthesiology, Surgical Intensive Care, Emergency and Pain Medicine, Ruhr University Bochum, 32049 Herford, Germany.<br /><searchLink fieldCode="AU" term="%22Babel+N%22">Babel N</searchLink>; Centrum für Translationale Medizin mit Schwerpunkt Immunologie und Transplantation, Marien Hospital Herne, Universitätsklinikum der Ruhr-Universität Bochum, 44625 Herne, Germany.<br /><searchLink fieldCode="AU" term="%22Eisenacher+M%22">Eisenacher M</searchLink>; Ruhr University Bochum, Medical Faculty, Medizinisches Proteom-Center, 44801 Bochum, Germany.; Ruhr University Bochum, Medical Faculty, CUBiMed.RUB, Core Unit Bioinformatics, 44801 Bochum, Germany.; Ruhr University Bochum, Medical Proteome Analysis, Center for Proteindiagnostics (PRODI), 44801 Bochum, Germany.<br /><searchLink fieldCode="AU" term="%22Marcus+K%22">Marcus K</searchLink>; Ruhr University Bochum, Medical Faculty, Medizinisches Proteom-Center, 44801 Bochum, Germany.<br /><searchLink fieldCode="AU" term="%22Ellger+B%22">Ellger B</searchLink>; Department of Anesthesiology, Intensive Care and Pain Medicine, Klinikum Westfalen, 44309 Dortmund, Germany.<br /><searchLink fieldCode="AU" term="%22Koos+B%22">Koos B</searchLink>; Ruhr University Bochum, Knappschaft Kliniken University Hospital Bochum, Department of Anesthesiology, Intensive Care Medicine and Pain Therapy, Center for Perioperative Precision Medicine, 44892 Bochum, Germany.<br /><searchLink fieldCode="AU" term="%22Adamzik+M%22">Adamzik M</searchLink>; Ruhr University Bochum, Knappschaft Kliniken University Hospital Bochum, Department of Anesthesiology, Intensive Care Medicine and Pain Therapy, 44892 Bochum, Germany.<br /><searchLink fieldCode="AU" term="%22Witowski+A%22">Witowski A</searchLink>; Ruhr University Bochum, Knappschaft Kliniken University Hospital Bochum, Department of Anesthesiology, Intensive Care Medicine and Pain Therapy, 44892 Bochum, Germany.; Ruhr University Bochum, Knappschaft Kliniken University Hospital Bochum, Department of Anesthesiology, Intensive Care Medicine and Pain Therapy, Center for Perioperative Precision Medicine, 44892 Bochum, Germany.
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