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Activation of farnesoid X receptor inhibits TMEM16A-mediated chloride secretion in renal collecting duct cells and retards renal cyst progression.

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Title: Activation of farnesoid X receptor inhibits TMEM16A-mediated chloride secretion in renal collecting duct cells and retards renal cyst progression.
Authors: Srimai N; Research Center of Transporter Protein for Medical Innovation, Department of Physiology, Faculty of Science, Mahidol University, Bangkok, Thailand.; Faculty of Medicine, Praboromarajchanok Institute, Ministry of Public Health, Nonthaburi, Thailand., Tonum K; Department of Physiology, Faculty of Pharmacy, Mahidol University, Bangkok, Thailand., Sureram S; Chulabhorn Research Institute, Bangkok, Thailand.; Program in Chemical Sciences, Chulabhorn Graduate Institute, Chulabhorn Royal Academy, Bangkok, Thailand.; Center of Excellence on Environmental Health and Toxicology (EHT), OPS, Ministry of Higher Education, Science, Research and Innovation, Bangkok, Thailand., Tubsuwan A; Institute of Molecular Biosciences, Mahidol University, Nakhon Pathom, Thailand., Kittakoop P; Chulabhorn Research Institute, Bangkok, Thailand.; Program in Chemical Sciences, Chulabhorn Graduate Institute, Chulabhorn Royal Academy, Bangkok, Thailand.; Center of Excellence on Environmental Health and Toxicology (EHT), OPS, Ministry of Higher Education, Science, Research and Innovation, Bangkok, Thailand., Soodvilai S; Research Center of Transporter Protein for Medical Innovation, Department of Physiology, Faculty of Science, Mahidol University, Bangkok, Thailand.; Excellent Center for Drug Discovery, Mahidol University, Bangkok, Thailand.
Source: American journal of physiology. Renal physiology [Am J Physiol Renal Physiol] 2026 Apr 01; Vol. 330 (4), pp. F444-F455. Date of Electronic Publication: 2026 Feb 27.
Publication Type: Journal Article
Journal Info: Publisher: American Physiological Society Country of Publication: United States NLM ID: 100901990 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1522-1466 (Electronic) Linking ISSN: 15221466 NLM ISO Abbreviation: Am J Physiol Renal Physiol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Activation of farnesoid X receptor inhibits TMEM16A-mediated chloride secretion in renal collecting duct cells and retards renal cyst progression.
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  Data: <searchLink fieldCode="AU" term="%22Srimai+N%22">Srimai N</searchLink>; Research Center of Transporter Protein for Medical Innovation, Department of Physiology, Faculty of Science, Mahidol University, Bangkok, Thailand.; Faculty of Medicine, Praboromarajchanok Institute, Ministry of Public Health, Nonthaburi, Thailand.<br /><searchLink fieldCode="AU" term="%22Tonum+K%22">Tonum K</searchLink>; Department of Physiology, Faculty of Pharmacy, Mahidol University, Bangkok, Thailand.<br /><searchLink fieldCode="AU" term="%22Sureram+S%22">Sureram S</searchLink>; Chulabhorn Research Institute, Bangkok, Thailand.; Program in Chemical Sciences, Chulabhorn Graduate Institute, Chulabhorn Royal Academy, Bangkok, Thailand.; Center of Excellence on Environmental Health and Toxicology (EHT), OPS, Ministry of Higher Education, Science, Research and Innovation, Bangkok, Thailand.<br /><searchLink fieldCode="AU" term="%22Tubsuwan+A%22">Tubsuwan A</searchLink>; Institute of Molecular Biosciences, Mahidol University, Nakhon Pathom, Thailand.<br /><searchLink fieldCode="AU" term="%22Kittakoop+P%22">Kittakoop P</searchLink>; Chulabhorn Research Institute, Bangkok, Thailand.; Program in Chemical Sciences, Chulabhorn Graduate Institute, Chulabhorn Royal Academy, Bangkok, Thailand.; Center of Excellence on Environmental Health and Toxicology (EHT), OPS, Ministry of Higher Education, Science, Research and Innovation, Bangkok, Thailand.<br /><searchLink fieldCode="AU" term="%22Soodvilai+S%22">Soodvilai S</searchLink>; Research Center of Transporter Protein for Medical Innovation, Department of Physiology, Faculty of Science, Mahidol University, Bangkok, Thailand.; Excellent Center for Drug Discovery, Mahidol University, Bangkok, Thailand.
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  Data: <searchLink fieldCode="JN" term="%22100901990%22">American journal of physiology. Renal physiology</searchLink> [Am J Physiol Renal Physiol] 2026 Apr 01; Vol. 330 (4), pp. F444-F455. <i>Date of Electronic Publication: </i>2026 Feb 27.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Physiological+Society%22">American Physiological Society </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>100901990 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1522-1466 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2215221466%22">15221466 </searchLink><i>NLM ISO Abbreviation: </i>Am J Physiol Renal Physiol <i>Subsets: </i>MEDLINE
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        Value: 10.1152/ajprenal.00370.2025
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        Text: English
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        StartPage: F444
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      – TitleFull: Activation of farnesoid X receptor inhibits TMEM16A-mediated chloride secretion in renal collecting duct cells and retards renal cyst progression.
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              Text: 2026 Apr 01
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              Y: 2026
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