Early Safety of Ultra-Hypofractionated Whole Breast Irradiation and Sequential Tumor Bed Boost for Early Breast Cancer (SHIFT): A Multicenter, Phase 2 Trial.

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Title: Early Safety of Ultra-Hypofractionated Whole Breast Irradiation and Sequential Tumor Bed Boost for Early Breast Cancer (SHIFT): A Multicenter, Phase 2 Trial.
Authors: Zheng SY; Department of Radiation Oncology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, China; Shanghai Key Laboratory of Proton-therapy, Shanghai, China., Huang JQ; Department of Radiation Oncology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, China; Shanghai Key Laboratory of Proton-therapy, Shanghai, China., Xie JR; Department of Radiation Oncology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, China; Department of Oncology, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China., Gan L; Department of Oncology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China., Yu B; Department of Radiotherapy, The Affiliated Jiangyin People's Hospital of Nantong University, Jiangyin, China., Shi YG; Department of Radiation Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China., Jiang J; Department of Oncology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China., Zhang J; Department of Oncology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China., Dong ML; Department of Radiation Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China., Qi WX; Department of Radiation Oncology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, China; Shanghai Key Laboratory of Proton-therapy, Shanghai, China., Cai G; Department of Radiation Oncology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, China; Shanghai Key Laboratory of Proton-therapy, Shanghai, China., Cai R; Department of Radiation Oncology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, China; Shanghai Key Laboratory of Proton-therapy, Shanghai, China., Xu C; Department of Radiation Oncology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, China; Shanghai Key Laboratory of Proton-therapy, Shanghai, China., Xu HP; Department of Radiation Oncology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, China; Shanghai Key Laboratory of Proton-therapy, Shanghai, China., Qian XF; Department of Radiation Oncology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, China; Shanghai Key Laboratory of Proton-therapy, Shanghai, China., Zhang YB; Department of Radiation Oncology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, China; Shanghai Key Laboratory of Proton-therapy, Shanghai, China., Cao L; Department of Radiation Oncology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, China; Shanghai Key Laboratory of Proton-therapy, Shanghai, China. Electronic address: cl11879@rjh.com.cn., Chen JY; Department of Radiation Oncology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, China; Shanghai Key Laboratory of Proton-therapy, Shanghai, China. Electronic address: cjy11756@rjh.com.cn.
Source: International journal of radiation oncology, biology, physics [Int J Radiat Oncol Biol Phys] 2026 Feb 25. Date of Electronic Publication: 2026 Feb 25.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier, Inc Country of Publication: United States NLM ID: 7603616 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-355X (Electronic) Linking ISSN: 03603016 NLM ISO Abbreviation: Int J Radiat Oncol Biol Phys Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1879-355X
DOI:10.1016/j.ijrobp.2026.02.233