Activation of IRF3 in cardiomyocytes impairs mitochondrial oxidative function through PGC-1α inhibition and drives heart failure.
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| Title: | Activation of IRF3 in cardiomyocytes impairs mitochondrial oxidative function through PGC-1α inhibition and drives heart failure. |
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| Authors: | Kumari M; Department of Cardiology, Angiology and Pneumology, Internal Medicine III, University Hospital Heidelberg, Heidelberg, Germany. manju.kumari@med.uni-heidelberg.de.; Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. manju.kumari@med.uni-heidelberg.de.; DZHK (German Centre for Cardiovascular Research), partner site Heidelberg/Mannheim, Heidelberg, Germany. manju.kumari@med.uni-heidelberg.de., Evangelakos I; Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Deshpande A; Department of Cardiology, Angiology and Pneumology, Internal Medicine III, University Hospital Heidelberg, Heidelberg, Germany.; DZHK (German Centre for Cardiovascular Research), partner site Heidelberg/Mannheim, Heidelberg, Germany., De Jong KA; Institute of Experimental Cardiovascular Research, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Schmiedel N; Department of Internal Medicine III, University Medical Center Schleswig-Holstein, Kiel, Germany., Palacio-Escat N; Institute for Computational Biomedicine, University Hospital Heidelberg, Heidelberg, Germany., Chaves-Filho AB; German Cancer Research Center, Division of Tumor Metabolism and Microenvironment, Heidelberg, Germany., Frias-Soler RC; German Cancer Research Center, Division of Tumor Metabolism and Microenvironment, Heidelberg, Germany., Klinke G; Metabolomics Core Technology Platform, Centre for Organismal Studies (COS), Heidelberg University, Heidelberg, Germany., Roh HC; Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN, USA., Lange L; Department of Cardiology, Angiology and Pneumology, Internal Medicine III, University Hospital Heidelberg, Heidelberg, Germany., Berlin M; Division of Pharmacology, University Hospital Heidelberg, Heidelberg, Germany., Fuh MM; Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Buss JJ; Department of Cardiology, Angiology and Pneumology, Internal Medicine III, University Hospital Heidelberg, Heidelberg, Germany.; DZHK (German Centre for Cardiovascular Research), partner site Heidelberg/Mannheim, Heidelberg, Germany., Tian T; Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Lerchenmüller C; Department of Cardiology, Angiology and Pneumology, Internal Medicine III, University Hospital Heidelberg, Heidelberg, Germany.; DZHK (German Centre for Cardiovascular Research), partner site Heidelberg/Mannheim, Heidelberg, Germany.; Department of Cardiology, University Hospital Zurich, Zurich, Switzerland., Freichel M; Division of Pharmacology, University Hospital Heidelberg, Heidelberg, Germany., Schulze A; German Cancer Research Center, Division of Tumor Metabolism and Microenvironment, Heidelberg, Germany., Nikolaev VO; Institute of Experimental Cardiovascular Research, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Eschenhagen T; Institute of Experimental Pharmacology and Toxicology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Rosen ED; Division of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center, Boston, MA, USA.; Broad Institute of Harvard and MIT, Cambridge, MA, USA., Scheja L; Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Rangrez AY; Department of Cardiology, Angiology and Pneumology, Internal Medicine III, University Hospital Heidelberg, Heidelberg, Germany.; DZHK (German Centre for Cardiovascular Research), partner site Heidelberg/Mannheim, Heidelberg, Germany., Heeren J; Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. heeren@uke.de., Frey N; Department of Cardiology, Angiology and Pneumology, Internal Medicine III, University Hospital Heidelberg, Heidelberg, Germany. norbert.frey@med.uni-heidelberg.de.; DZHK (German Centre for Cardiovascular Research), partner site Heidelberg/Mannheim, Heidelberg, Germany. norbert.frey@med.uni-heidelberg.de. |
| Source: | Nature communications [Nat Commun] 2026 Feb 27; Vol. 17 (1). Date of Electronic Publication: 2026 Feb 27. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2041-1723 |
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| DOI: | 10.1038/s41467-026-69792-4 |
