A small-molecule inverse agonist of PPARγ for advanced solid tumors: a phase 1 trial.

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Title: A small-molecule inverse agonist of PPARγ for advanced solid tumors: a phase 1 trial.
Authors: Galsky MD; Mount Sinai Tisch Cancer Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA. matthew.galsky@mssm.edu., Mantia C; Dana-Farber Cancer Institute, Boston, MA, USA., Bowden M; Flare Therapeutics Inc., Cambridge, MA, USA., Bellmunt J; Dana-Farber Cancer Institute, Boston, MA, USA., Garmezy B; Sarah Cannon Research Institute, Nashville, TN, USA., Iyer G; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Petrylak DP; Smilow Cancer Hospital, Yale New Haven Health, New Haven, CT, USA., Rasco D; START Center for Cancer Research, San Antonio, TX, USA., Gupta S; Cleveland Clinic Taussig Cancer Institute, Cleveland, OH, USA., Rodriguez-Rivera I; NEXT Oncology, San Antonio, TX, USA., Mikhailov Y; Flare Therapeutics Inc., Cambridge, MA, USA., Joshi A; Flare Therapeutics Inc., Cambridge, MA, USA., Nguyen PA; Flare Therapeutics Inc., Cambridge, MA, USA., Kakrecha B; Flare Therapeutics Inc., Cambridge, MA, USA., Tepper J; Flare Therapeutics Inc., Cambridge, MA, USA., Costa AM; Flare Therapeutics Inc., Cambridge, MA, USA., McCrone C; Flare Therapeutics Inc., Cambridge, MA, USA., Rossi AP; Flare Therapeutics Inc., Cambridge, MA, USA., Mertz JA; Flare Therapeutics Inc., Cambridge, MA, USA., Gjini E; Flare Therapeutics Inc., Cambridge, MA, USA., Meyers ML; Flare Therapeutics Inc., Cambridge, MA, USA., Milowsky MI; UNC Lineberger Comprehensive Cancer Center, Chapel Hill, NC, USA., Gao X; Massachusetts General Hospital Cancer Center, Boston, MA, USA.
Source: Nature medicine [Nat Med] 2026 Apr; Vol. 32 (4), pp. 1249-1256. Date of Electronic Publication: 2026 Feb 28.
Publication Type: Journal Article; Clinical Trial, Phase I
Journal Info: Publisher: Nature Publishing Company Country of Publication: United States NLM ID: 9502015 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-170X (Electronic) Linking ISSN: 10788956 NLM ISO Abbreviation: Nat Med Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1546-170X
DOI:10.1038/s41591-026-04263-3