Soluble Notch agonist enables human ameloblast maturation and enamel-like tissue formation for tooth regeneration.

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Title: Soluble Notch agonist enables human ameloblast maturation and enamel-like tissue formation for tooth regeneration.
Authors: Patni AP; Department of Oral Health Sciences, University of Washington, School of Dentistry, Seattle, WA, USA.; Department of Biochemistry, University of Washington, School of Medicine, Seattle, WA, USA.; Institute for Stem Cell and Regenerative Medicine, University of Washington, School of Medicine, Seattle, WA, USA., Mout R; Stem Cell & Regenerative Biology Program, Boston Children's Hospital, Boston, MA, USA.; Department of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.; Harvard Stem Cell Institute, Harvard University, Cambridge, MA, USA., Alghadeer A; Department of Biomedical Dental Sciences, College of Dentistry, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia., Moore RH; Institute for Stem Cell and Regenerative Medicine, University of Washington, School of Medicine, Seattle, WA, USA.; Department of Comparative Medicine, University of Washington, School of Medicine, Seattle, WA, USA., Nademi S; Institute for Stem Cell and Regenerative Medicine, University of Washington, School of Medicine, Seattle, WA, USA.; Department of Medicine, Division of Nephrology, Kidney Research Institute and Institute for Stem Cell and Regenerative Medicine, Seattle, WA, USA., Ausk BJ; Department of Orthopaedic Surgery and Sports Medicine University of Washington Seattle, Seattle, WA, USA., Huber P; Department of Orthopaedic Surgery and Sports Medicine University of Washington Seattle, Seattle, WA, USA., Keshri R; Department of Biochemistry, University of Washington, School of Medicine, Seattle, WA, USA.; Institute for Stem Cell and Regenerative Medicine, University of Washington, School of Medicine, Seattle, WA, USA., Regier M; Institute for Stem Cell and Regenerative Medicine, University of Washington, School of Medicine, Seattle, WA, USA., Cornell RA; Department of Oral Health Sciences, University of Washington, School of Dentistry, Seattle, WA, USA.; Institute for Stem Cell and Regenerative Medicine, University of Washington, School of Medicine, Seattle, WA, USA., Gross T; Department of Orthopaedic Surgery and Sports Medicine University of Washington Seattle, Seattle, WA, USA., Freedman BS; Department of Medicine, Division of Nephrology, Kidney Research Institute and Institute for Stem Cell and Regenerative Medicine, Seattle, WA, USA., Daley GQ; Stem Cell & Regenerative Biology Program, Boston Children's Hospital, Boston, MA, USA.; Department of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.; Harvard Stem Cell Institute, Harvard University, Cambridge, MA, USA., Baker D; Department of Biochemistry, University of Washington, School of Medicine, Seattle, WA, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA.; Howard Hughes Medical Institute, University of Washington, Seattle, WA, USA., Mathieu J; Department of Biochemistry, University of Washington, School of Medicine, Seattle, WA, USA.; Institute for Stem Cell and Regenerative Medicine, University of Washington, School of Medicine, Seattle, WA, USA.; Department of Comparative Medicine, University of Washington, School of Medicine, Seattle, WA, USA., Ruohola-Baker H; Department of Oral Health Sciences, University of Washington, School of Dentistry, Seattle, WA, USA. hannele@uw.edu.; Department of Biochemistry, University of Washington, School of Medicine, Seattle, WA, USA. hannele@uw.edu.; Institute for Stem Cell and Regenerative Medicine, University of Washington, School of Medicine, Seattle, WA, USA. hannele@uw.edu.
Source: International journal of oral science [Int J Oral Sci] 2026 Mar 02; Vol. 18 (1). Date of Electronic Publication: 2026 Mar 02.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
Journal Info: Publisher: Nature Publishing Group Country of Publication: India NLM ID: 101504351 Publication Model: Electronic Cited Medium: Internet ISSN: 2049-3169 (Electronic) Linking ISSN: 16742818 NLM ISO Abbreviation: Int J Oral Sci Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2049-3169
DOI:10.1038/s41368-026-00429-4