A novel cell indirect calorimetry method unveils the metabolic fluxomic signatures of human monocyte-derived M(LPS + IFN-γ) and M(IL-4) macrophages.

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Title: A novel cell indirect calorimetry method unveils the metabolic fluxomic signatures of human monocyte-derived M(LPS + IFN-γ) and M(IL-4) macrophages.
Authors: Cinquegrani G; Laboratory of Endocrinology, Diabetology and Metabolic Diseases, Department of Medicine and Surgery, University of Parma, Parma, Italy., Spigoni V; Laboratory of Endocrinology, Diabetology and Metabolic Diseases, Department of Medicine and Surgery, University of Parma, Parma, Italy., Fantuzzi F; Laboratory of Endocrinology, Diabetology and Metabolic Diseases, Department of Medicine and Surgery, University of Parma, Parma, Italy., D'Antuono A; Laboratory of Endocrinology, Diabetology and Metabolic Diseases, Department of Medicine and Surgery, University of Parma, Parma, Italy., Bagnaresi F; Laboratory of Endocrinology, Diabetology and Metabolic Diseases, Department of Medicine and Surgery, University of Parma, Parma, Italy., Giordano E; Laboratory of Endocrinology, Diabetology and Metabolic Diseases, Department of Medicine and Surgery, University of Parma, Parma, Italy., Burato A; Guglielmo Marconi Institute of Industrial Technology, Verona, Italy., Dei Cas A; Laboratory of Endocrinology, Diabetology and Metabolic Diseases, Department of Medicine and Surgery, University of Parma, Parma, Italy.; Division of Endocrinology and Metabolic Diseases, Azienda Ospedaliero-Universitaria of Parma, Parma, Italy., Bonadonna RC; Laboratory of Endocrinology, Diabetology and Metabolic Diseases, Department of Medicine and Surgery, University of Parma, Parma, Italy.; Department of Medicine, University of Verona, Verona, Italy.; Division of Endocrinology, Diabetology and Metabolic Diseases, Azienda Ospedaliera Universitaria Integrata di Verona, Verona, Italy.
Source: American journal of physiology. Cell physiology [Am J Physiol Cell Physiol] 2026 Apr 01; Vol. 330 (4), pp. C954-C973. Date of Electronic Publication: 2026 Mar 02.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Physiological Society Country of Publication: United States NLM ID: 100901225 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1522-1563 (Electronic) Linking ISSN: 03636143 NLM ISO Abbreviation: Am J Physiol Cell Physiol Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1522-1563
DOI:10.1152/ajpcell.00635.2025